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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox4
SRY (sex determining region Y)-box 4
MGI:98366
86 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxq1sa/Foxq1+
Sox4M91Ark/Sox4+
involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR 		increased anxiety-related response J:101156
Foxq1sa/Foxq1+
Sox4M91Ark/Del(13)36H
involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR 		abnormal aortic arch morphology J:101156
abnormal cardiovascular development J:101156
abnormal heart development J:101156
abnormal heart morphology J:101156
abnormal kidney development J:101156
abnormal mitral valve morphology J:101156
double outlet right ventricle J:101156
holoprosencephaly J:101156
ostium primum atrial septal defect J:101156
prenatal lethality, complete penetrance J:101156
renal hypoplasia J:101156
ventricular septal defect J:101156
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * C57BL/6J * CBA/J 		abnormal pharyngeal arch development J:175338
Insrtm1Dac/Insr+
Sox4Igt4/Sox4+
involves: C3H/HeH * C57BL/6 		impaired glucose tolerance J:141688
Sox4Igt4/Del(13)36H
involves: 101/H * C3H/HeH * C57BL/6 		abnormal atrioventricular valve morphology J:141688
cleft palate J:141688
double outlet right ventricle J:141688
extremity edema J:141688
interrupted aortic arch J:141688
lethality throughout fetal growth and development, complete penetrance J:141688
renal hypoplasia J:141688
subarterial ventricular septal defect J:141688
thymus hypoplasia J:141688
Sox11tm1.1Gan/Sox11tm1.1Gan
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal eye development J:199663
abnormal retina bipolar cell morphology J:199663
abnormal retina outer plexiform layer morphology J:199663
absent optic nerve J:199663
absent retina ganglion cell J:199663
absent retina ganglion layer J:199663
absent retina inner plexiform layer J:199663
decreased amacrine cell number J:199663
decreased birth body size J:199663
decreased retina ganglion cell number J:199663
increased retina apoptosis J:199663
postnatal lethality, complete penetrance J:199663
thin retina ganglion layer J:199663
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal innervation pattern to muscle J:157923
abnormal Meibomian gland morphology J:157923
abnormal stellate ganglion morphology J:157923
abnormal sympathetic neuron innervation pattern J:157923
blepharoptosis J:157923
small superior cervical ganglion J:157923
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL/J 		abnormal limb mesenchyme morphology J:175338
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal limb mesenchyme morphology J:175338
Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
involves: 129 * C57BL/6 * FVB/N 		abnormal bone mineralization J:175338
abnormal cranium morphology J:175338
abnormal lumbar vertebrae morphology J:175338
abnormal sternebra morphology J:175338
abnormal xiphoid process morphology J:175338
normal craniofacial phenotype J:175338
double outlet right ventricle J:175338
omphalocele J:175338
perinatal lethality, complete penetrance J:175338
small spleen J:175338
sternebra fusion J:175338
ventricular septal defect J:175338
normal vision/eye phenotype J:175338
wide cranial sutures J:175338
Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk
involves: 129 * C57BL/6 * CBA * FVB/N 		abnormal notochord morphology J:175338
abnormal vertebrae morphology J:175338
double outlet right ventricle J:175338
ventricular septal defect J:175338
Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4tm1.1Vlf
involves: 129 * C57BL/6 * FVB/N 		abnormal pharyngeal arch mesenchyme morphology J:175338
decreased embryo size J:175338
embryonic lethality during organogenesis, complete penetrance J:175338
failure of heart looping J:175338
incomplete embryo turning J:175338
open neural tube J:175338
Sox11tm1.2Vlf/Sox11+
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal bone mineralization J:175338
abnormal cranium morphology J:175338
abnormal sternebra morphology J:175338
abnormal vertebrae morphology J:175338
double outlet right ventricle J:175338
persistent truncus arteriosus J:175338
small spleen J:175338
sternebra fusion J:175338
ventricular septal defect J:175338
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1.1Vlf/Sox4+
involves: 129 * C57BL/6 * FVB/N 		abnormal eye development J:175338
abnormal lung development J:175338
abnormal skeleton development J:175338
aphakia J:175338
edema J:175338
eyelids open at birth J:175338
lethality throughout fetal growth and development, complete penetrance J:175338
micrognathia J:175338
microphthalmia J:175338
myocardium hypoplasia J:175338
persistent truncus arteriosus J:175338
semilunar valve hypoplasia J:175338
small lung J:175338
sternum hypoplasia J:175338
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1.1Vlf/Sox4tm1.1Vlf
involves: 129 * C57BL/6 * FVB/N 		abnormal cell death J:175338
abnormal heart development J:175338
abnormal neural tube morphology J:175338
abnormal pharyngeal arch development J:175338
abnormal pharyngeal arch mesenchyme morphology J:175338
absent limb buds J:175338
cardia bifida J:175338
decreased cell proliferation J:175338
decreased embryo size J:175338
embryonic growth arrest J:175338
embryonic lethality during organogenesis, complete penetrance J:175338
impaired somite development J:175338
incomplete embryo turning J:175338
incomplete rostral neuropore closure J:175338
wavy neural tube J:175338
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Pou3f4-cre)32Cren/0
involves: 129 * C57BL/6 * CD-1 * FVB/N 		abnormal neural tube morphology J:175338
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4tm1.1Vlf
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal neural tube morphology J:175338
kinked neural tube J:175338
Sox11tm1Weg/Sox11tm1Weg
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal nervous system development J:157923
abnormal sympathetic ganglion morphology J:157923
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory