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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sparc
secreted acidic cysteine rich glycoprotein
MGI:98373
41 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
B6Dnk;B6Brd;B6N-Tyrc-Brd Sparctm1a(EUCOMM)Wtsi/Wtsi 		abnormal coat/hair pigmentation J:232539
abnormal incisor color J:232539
Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi 		abnormal coat/hair pigmentation J:175295
abnormal eye morphology J:165965, J:175295
abnormal humerus morphology J:175295
abnormal incisor color J:175295
abnormal lens morphology J:165965, J:175295
abnormal tibia morphology J:175295
abnormal tooth morphology J:175295
cataract J:165965, J:175295
decreased body length J:165965
decreased body weight J:165965, J:175295
decreased bone mineral content J:165965
decreased bone mineral density J:165965
decreased heart weight J:165965
decreased lean body mass J:165965
decreased mean corpuscular hemoglobin concentration J:175295
Sparctm1Anjm/Sparctm1Anjm
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:155870
Sparctm1Cam/Sparctm1Cam
involves: 129S/SvEv * MF1 		abnormal retina layer morphology J:47014
subcapsular cataract J:47014
Sparctm1Hwe/Sparctm1Hwe
involves: 129S/SvEv * C57BL/6J 		abnormal bone remodeling J:61480
abnormal bone strength J:61480
abnormal lens capsule morphology J:52120, J:53514
abnormal lens epithelium morphology J:53514
abnormal lens fiber morphology J:52120, J:53514
abnormal lens morphology J:52120, J:53514
abnormal osteoblast morphology J:61480
abnormal osteoclast morphology J:61480
abnormal skeleton morphology J:61480
abnormal skeleton physiology J:61480
abnormal trabecular bone morphology J:61480
cortical cataract J:52120
decreased bone mineral density J:61480
decreased locomotor activity J:52120
decreased osteoblast cell number J:61480
decreased osteoclast cell number J:61480
delayed wound healing J:102567
enhanced wound healing J:73724
eye inflammation J:52120
increased tumor growth/size J:81896
posterior subcapsular cataract J:53514
retina degeneration J:52120
retina detachment J:52120
ruptured lens capsule J:52120
vitreous body inflammation J:52120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory