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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spta1
spectrin alpha, erythrocytic 1
MGI:98385
109 phenotypes from 9 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Spta1em1(IMPC)Bay/Spta1+
C57BL/6N-Spta1em1(IMPC)Bay/BayMmucd 		increased startle reflex J:211773
Spta1em1(IMPC)Bay/Spta1em1(IMPC)Bay
C57BL/6N-Spta1em1(IMPC)Bay/BayMmucd 		preweaning lethality, complete penetrance J:211773
Spta1ihj/Spta1+
involves: HRS/J * LAH 		abnormal fertility/fecundity J:105409
Spta1ihj/Spta1ihj
involves: HRS/J * LAH 		abnormal feces composition J:105409
abnormal maternal nurturing J:105409
abnormal spleen morphology J:105409
anisocytosis J:105409
decreased body size J:105409
delayed hair appearance J:105409
enlarged liver J:105409
enlarged spleen J:105409
hemolytic anemia J:105409
increased circulating bilirubin level J:105409
jaundice J:105409
microcytosis J:105409
pallor J:105409
poikilocytosis J:105409
polychromatophilia J:105409
postnatal lethality J:105409
reduced female fertility J:105409
reticulocytosis J:105409
spherocytosis J:105409
Spta1sph-2Bc/Spta1sph-2Bc
(WB.Cg-Spta1sph-2Bc/Brk x B6.Cg-Spta1sph-2Bc/Brk)F1 		abnormal cardiac thrombosis J:62355
abnormal erythrocyte morphology J:62355
abnormal red blood cell deformability J:81125
microcytosis J:62355
Spta1sph-2Bc/Spta1sph-2Bc
involves: SELH 		abnormal erythrocyte morphology J:7048, J:7501
abnormal spleen morphology J:7048
anisocytosis J:7048
decreased hematocrit J:7048
decreased hemoglobin content J:7048
enlarged spleen J:7048
erythroblastosis J:7048
extramedullary hematopoiesis J:7048
hemolytic anemia J:7048
increased bone marrow cell number J:7048
increased circulating bilirubin level J:7048
increased erythrocyte osmotic fragility J:7048
increased leukocyte cell number J:7048
jaundice J:7048
pallor J:7048
poikilocytosis J:7048
postnatal lethality, incomplete penetrance J:7048
premature death J:7048
reticulocytosis J:7048
schistocytosis J:7048
spherocytosis J:7048
Spta1sph-2J/Spta1sph-2J
C3HeB/FeJ-Spta1sph-2J 		abnormal reticulocyte morphology J:7501
Spta1sph-3J/Spta1sph-3J
NOD.Cg-H2b Spta1sph-3J 		abnormal erythrocyte morphology J:157766
anemia J:157766
anisocytosis J:157766
anisopoikilocytosis J:157766
decreased erythrocyte cell number J:157766
decreased hematocrit J:157766
decreased hemoglobin content J:157766
decreased mean corpuscular hemoglobin concentration J:157766
decreased spleen iron level J:157766
elliptocytosis J:157766
enlarged spleen J:157766
extramedullary hematopoiesis J:157766
hemolytic anemia J:157766
increased circulating bilirubin level J:157766
increased circulating iron level J:157766
increased kidney iron level J:157766
increased liver iron level J:157766
increased spleen weight J:157766
poikilocytosis J:157766
polychromatophilia J:157766
reticulocytosis J:157766
spherocytosis J:157766
Spta1sph-4J/Spta1sph-4J
C57BL/6J-Spta1sph-4J/Llp 		abnormal erythrocyte morphology J:157766
anemia J:157766
anisocytosis J:157766
anisopoikilocytosis J:157766
decreased erythrocyte cell number J:157766
decreased hematocrit J:157766
decreased hemoglobin content J:157766
decreased mean corpuscular hemoglobin concentration J:157766
enlarged spleen J:157766
extramedullary hematopoiesis J:157766
hemolytic anemia J:157766
increased circulating bilirubin level J:157766
increased circulating iron level J:157766
increased kidney iron level J:157766
increased liver iron level J:157766
increased mean corpuscular volume J:157766
increased spleen weight J:157766
poikilocytosis J:157766
polychromatophilia J:157766
reticulocytosis J:157766
spherocytosis J:157766
Spta1sph-Dem/Spta1sph-Dem
CcS3/Dem-Spta1sph-Dem 		abnormal cardiac thrombosis J:62355
abnormal erythrocyte morphology J:62355
anemia J:66966
elliptocytosis J:62355, J:66966
enlarged spleen J:66966
jaundice J:66966
liver degeneration J:66966
microcytosis J:62355
renal necrosis J:66966
Spta1sph-ha/Spta1+
either: (B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1 		increased erythrocyte protoporphyrin level J:5985
Spta1sph-ha/Spta1+
involves: DBA/1J 		increased erythrocyte clearance J:24829
Spta1sph-ha/Spta1sph-ha
(WB.D1-Spta1sph-ha/Brk x B6.D1-Spta1sph-ha/Brk)F1 		abnormal cardiac thrombosis J:62355
abnormal erythrocyte morphology J:62355
abnormal erythrocyte physiology J:162532
abnormal red blood cell deformability J:81125
anisopoikilocytosis J:162532
cardiac hypertrophy J:162532
decreased body size J:162532
decreased hematocrit J:162532
decreased hemoglobin content J:162532
enlarged liver J:162532
enlarged spleen J:162532
extramedullary hematopoiesis J:162532
hemolysis J:162532
hemolytic anemia J:162532
increased circulating bilirubin level J:162532
increased erythrocyte clearance J:162532
increased erythrocyte osmotic fragility J:162532
increased mean corpuscular volume J:162532
increased nucleated erythrocyte cell number J:162532
infertility J:162532
jaundice J:162532
low mean erythrocyte cell number J:162532
microcytosis J:62355
poikilocytosis J:162532
preweaning lethality, incomplete penetrance J:162532
reticulocytosis J:162532
schistocytosis J:162532
Spta1sph-ha/Spta1sph-ha
either: (B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1 		abnormal bone marrow cell number J:1967, J:6695
abnormal erythrocyte physiology J:30033
abnormal erythropoiesis J:6695
abnormal lung morphology J:12830
abnormal lymph node cell ratio J:1967
abnormal spleen morphology J:6695
abnormal splenic cell ratio J:1967
abnormal thrombosis J:12830
alveolitis J:12830
blood vessel congestion J:12830
decreased hematocrit J:6695
enlarged spleen J:6695
extramedullary hematopoiesis J:12830
gallstones J:12830
hemolytic anemia J:1967, J:6695, J:12830
hemosiderosis J:12830
increased B cell number J:1967
increased B cell proliferation J:1967
increased bone marrow cell number J:6695, J:12830
increased CD4-positive, alpha-beta T cell number J:1967
increased CD8-positive, alpha-beta T cell number J:1967
increased circulating bilirubin level J:12830
increased erythrocyte protoporphyrin level J:5985, J:6695
increased erythroid progenitor cell number J:6695
increased IgA level J:12830
increased IgG level J:12830
increased leukocyte cell number J:12830
increased lymphocyte cell number J:1967, J:12830
increased monocyte cell number J:12830
increased neutrophil cell number J:12830
increased pulmonary alveolus wall thickness J:12830
increased susceptibility to bacterial infection J:12830
increased T cell number J:1967
increased T cell proliferation J:1967
interstitial pneumonia J:12830
lymph node hyperplasia J:1967, J:12830
macrocytosis J:6695
microcytosis J:6695
premature death J:12830
pulmonary fibrosis J:12830
reticulocytosis J:6695
spherocytosis J:6695
Spta1sph-ha/Spta1sph-ha
involves: DBA/1J 		abnormal bone marrow morphology J:30699
abnormal erythrocyte morphology J:30699
abnormal reticulocyte morphology J:7501
abnormal skin pigmentation J:14946
cardiac hypertrophy J:14946
decreased hematocrit J:24829
decreased hemoglobin content J:24829
decreased mean corpuscular volume J:24829
enlarged liver J:30699
enlarged spleen J:14946, J:30699
erythroblastosis J:14946
hemolytic anemia J:30699
hypochromic microcytic anemia J:14946
infertility J:24729
jaundice J:14946, J:24729, J:30699
microcytic anemia J:24729
microcytosis J:24729
postnatal lethality, incomplete penetrance J:24729, J:24829
prenatal lethality, incomplete penetrance J:24829
Spta1sph/Spta1+
either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1 		increased erythrocyte protoporphyrin level J:5985
Spta1sph/Spta1sph
(WB.C3-Spta1sph x B6.C3-Spta1sph)F1 		abnormal cardiac thrombosis J:44313, J:62355
abnormal erythrocyte morphology J:62355
abnormal erythrocyte osmotic lysis J:162532
abnormal erythrocyte physiology J:162532
anisopoikilocytosis J:162532
brain lesion J:44313
cardiac hypertrophy J:162532
cerebral infarct J:44313
decreased body size J:162532
decreased cellular hemoglobin content J:44313
decreased erythrocyte cell number J:44313
decreased hematocrit J:44313, J:162532
decreased hemoglobin content J:44313, J:162532
enlarged heart J:44313
enlarged liver J:162532
enlarged spleen J:44313, J:162532
extramedullary hematopoiesis J:162532
focal hepatic necrosis J:44313
glomerulonephritis J:44313
hemolysis J:162532
hemolytic anemia J:162532
increased circulating bilirubin level J:162532
increased erythrocyte clearance J:162532
increased kidney iron level J:44313
increased liver iron level J:44313
increased mean corpuscular volume J:162532
increased nucleated erythrocyte cell number J:162532
infertility J:162532
jaundice J:162532
low mean erythrocyte cell number J:162532
microcytosis J:62355
myocardium necrosis J:44313
poikilocytosis J:162532
postnatal lethality, incomplete penetrance J:44313, J:162532
premature death J:44313
renal tubular necrosis J:44313
reticulocytosis J:162532
schistocytosis J:162532
tubular nephritis J:44313
Spta1sph/Spta1sph
B6.C3-Spta1sph/BrkJ 		neonatal lethality, incomplete penetrance J:162758
postnatal lethality, incomplete penetrance J:162758
Spta1sph/Spta1sph
either: (B6.C3-Spta1sph x WB.C3-Spta1sph)F1 or (WB.C3-Spta1sph x B6.C3-Spta1sph)F1 		abnormal bone marrow cell number J:6695
abnormal erythrocyte physiology J:30033
abnormal erythropoiesis J:6695
abnormal spleen morphology J:6695
decreased hematocrit J:6695
decreased susceptibility to parasitic infection J:111131
enlarged spleen J:6695
hemolytic anemia J:6695
increased bone marrow cell number J:6695
increased erythrocyte protoporphyrin level J:5985, J:111131
increased erythroid progenitor cell number J:6695
macrocytosis J:6695
microcytosis J:6695
reticulocytosis J:6695
spherocytosis J:6695
Spta1sph/Spta1sph
involves: C3H 		abnormal liver morphology J:12276
abnormal reticulocyte morphology J:7501
decreased hematocrit J:12276
decreased hemoglobin content J:12276
dilated liver sinusoidal space J:12276
enlarged liver J:12276
hemolytic anemia J:12276
increased circulating bilirubin level J:12276
jaundice J:12276
liver vascular congestion J:12276
neonatal lethality, complete penetrance J:12276
pallor J:12276
poikilocytosis J:12276
spherocytosis J:12276
Spta1sph/Spta1sph
WB.C3-Spta1sph/BrkJ 		neonatal lethality, incomplete penetrance J:162758
postnatal lethality, complete penetrance J:162758
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory