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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sptbn1
spectrin beta, non-erythrocytic 1
MGI:98388
60 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sptbn1tm1.1Mnr/Sptbn1tm1.1Mnr
Tg(Nes-cre)1Kln/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL 		abnormal axon initial segment morphology J:186168
postnatal lethality, incomplete penetrance J:186168
Sptbn1tm1a(EUCOMM)Wtsi/Sptbn1+
B6JTyr;B6N-Sptbn1tm1a(EUCOMM)Wtsi/Wtsi 		decreased body weight J:175295
decreased circulating alanine transaminase level J:175295
decreased circulating cholesterol level J:175295
decreased circulating HDL cholesterol level J:175295
decreased circulating LDL cholesterol level J:175295
decreased circulating serum albumin level J:175295
decreased circulating total protein level J:175295
decreased lactate dehydrogenase level J:175295
Sptbn1tm1a(EUCOMM)Wtsi/Sptbn1tm1a(EUCOMM)Wtsi
involves: C57BL/6N 		abnormal fetal cardiomyocyte morphology J:219548
abnormal heart development J:219548
abnormal heart ventricle wall thickness J:219548
absent coronary vessels J:219548
decreased fetal cardiomyocyte proliferation J:219548
decreased mitotic index J:219548
edema J:200082
hemorrhage J:200082
increased fetal cardiomyocyte apoptosis J:219548
myocardial trabeculae hypoplasia J:219548
small heart J:219548
thin left ventricle myocardium compact layer J:219548
ventricular septal defect J:219548
Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
involves: C57BL/6J * C57BL/6N 		abnormal cell cycle J:219548
abnormal cell cycle checkpoint function J:219548
abnormal fetal cardiomyocyte morphology J:219548
abnormal fetal cardiomyocyte physiology J:219548
decreased fetal cardiomyocyte proliferation J:219548
increased fetal cardiomyocyte apoptosis J:219548
Sptbn1tm1Mish/Sptbn1+
involves: 129S6/SvEvTac 		abnormal liver morphology J:166879
abnormal outer ear morphology J:166879
adrenal gland cyst J:166879
alopecia J:166879
enlarged heart J:166879
enlarged kidney J:166879
enlarged testis J:166879
increased adenoma incidence J:166879
increased adrenal cortical tumor incidence J:166879
increased body size J:166879
increased carcinoma incidence J:166879
increased glioma incidence J:166879
increased hepatocellular carcinoma incidence J:166879
increased liver tumor incidence J:166879
increased lung adenocarcinoma incidence J:166879
increased lymphoma incidence J:166879
increased ovary tumor incidence J:166879
increased renal carcinoma incidence J:166879
increased sarcoma incidence J:166879
increased testis tumor incidence J:166879
increased thyroid carcinoma incidence J:166879
increased tongue size J:166879
premature death J:166879
visceromegaly J:166879
Sptbn1tm1Mish/Sptbn1+
involves: 129S6/SvEvTac * C57BL/6 		decreased hepatocyte proliferation J:132133
increased hepatocellular carcinoma incidence J:132133
Sptbn1tm1Mish/Sptbn1tm1Mish
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal brain development J:81747
abnormal craniofacial morphology J:81747
abnormal digestive system morphology J:81747
abnormal heart ventricle morphology J:81747
abnormal liver morphology J:81747
abnormal myocardial fiber morphology J:81747
abnormal vitelline vasculature morphology J:81747
decreased embryo size J:81747
lethality throughout fetal growth and development, complete penetrance J:81747
liver hypoplasia J:81747
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory