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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spp1
secreted phosphoprotein 1
MGI:98389
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Alpltm1Jlm/Alpltm1Jlm
Spp1tm1Rit/Spp1tm1Rit
involves: 129S1/SvImJ * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal dentin morphology J:233260
abnormal tooth root development J:233260
Alpltm1Jlm/Alpltm1Jlm
Spp1tm1Rit/Spp1tm1Rit
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal osteoblast physiology J:128077
decreased body weight J:128077
decreased bone mineralization J:128077
increased bone mineral density of lumbar vertebrae J:128077
increased bone mineral density of presacral vertebrae J:128077
increased bone trabecula number J:128077
postnatal lethality, complete penetrance J:128077
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J 		atherosclerotic lesions J:86531
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1tm1Blh
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J 		abnormal macrophage physiology J:86531
decreased susceptibility to atherosclerosis J:86531
decreased susceptibility to induced aneurysm formation J:86531
Apoetm1Unc/Apoetm1Unc
Spp1tm1Rit/Spp1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		decreased susceptibility to atherosclerosis J:103051
increased circulating cholesterol level J:103051
increased circulating triglyceride level J:103051
Apoetm1Unc/Apoetm1Unc
Spp1tm1Rit/Spp1tm1Rit
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		calcified artery J:103051
decreased susceptibility to atherosclerosis J:103051
increased circulating cholesterol level J:103051
increased circulating triglyceride level J:103051
Aprttm1Jat/Aprttm1Jat
Spp1tm1Rit/Spp1tm1Rit
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal body weight J:114314
abnormal kidney morphology J:114314
abnormal urine nucleoside level J:114314
decreased body weight J:114314
postnatal lethality J:114314
Dmdmdx/Dmdmdx
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn 		abnormal muscle physiology J:150572
abnormal physical strength J:150572
decreased granulocyte number J:150572
decreased neutrophil cell number J:150572
decreased T cell number J:150572
increased regulatory T cell number J:150572
increased T cell number J:150572
Dmdmdx/Y
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn 		abnormal muscle physiology J:150572
abnormal physical strength J:150572
decreased granulocyte number J:150572
decreased neutrophil cell number J:150572
decreased T cell number J:150572
increased regulatory T cell number J:150572
increased T cell number J:150572
Faslpr/Faslpr
Spp1tm1Rit/Spp1tm1Rit
involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp 		enlarged spleen J:73396
increased anti-double stranded DNA antibody level J:73396
increased anti-single stranded DNA antibody level J:73396
increased IgA level J:73396
increased IgG1 level J:73396
increased IgG2a level J:73396
increased IgG2b level J:73396
increased IgG3 level J:73396
increased IgM level J:73396
kidney inflammation J:73396
lymph node hyperplasia J:73396
Mgptm1Kry/Mgp+
Spp1tm1Blh/Spp1tm1Blh
involves: Black Swiss * C57BL/6J 		calcified artery J:79746
internal hemorrhage J:79746
premature death J:79746
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1+
involves: Black Swiss * C57BL/6J 		calcified artery J:79746
internal hemorrhage J:79746
premature death J:79746
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1tm1Blh
involves: Black Swiss * C57BL/6J 		abnormal aorta morphology J:79746
aneurysm J:79746
calcified artery J:79746
internal hemorrhage J:79746
premature death J:79746
Spp1tm1Blh/Spp1tm1Blh
Umodtm1Xrw/Umodtm1Xrw
129S/SvEv-Spp1tm1Blh Umodtm1Xrw 		crystalluria J:127526
dilated kidney collecting duct J:127526
increased urine phosphate level J:127526
increased urine uric acid level J:127526
nephrocalcinosis J:127526
renal fibrosis J:127526
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12/10/2024
MGI 6.24 		The Jackson Laboratory