Syn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Syn1
synapsin I
MGI:98460

17 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae	abnormal CNS synapse formation	J:30400
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae	abnormal synaptic vesicle clustering	J:30400
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae * C57BL/6	abnormal inhibitory postsynaptic currents	J:55506
	abnormal synaptic vesicle clustering	J:55506
	abnormal synaptic vesicle recycling	J:55506
Syn1^tm1Pggd/Syn1^tm1Pggd B6.129P2-Syn1^tm1Pggd	abnormal emotion/affect behavior	J:201707
	abnormal social investigation	J:201707
	impaired social transmission of food preference	J:201707
	increased aggression towards mice	J:201707
	normal taste/olfaction phenotype	J:201707
Syn1^tm1Pggd/Syn1^tm1Pggd involves: 129	abnormal excitatory postsynaptic potential	J:29086
	abnormal hippocampus pyramidal cell morphology	J:29085
	abnormal neurotransmitter secretion	J:29086
	abnormal seizure response to electrical stimulation	J:29086
	abnormal synaptic vesicle clustering	J:29086
	delayed CNS synapse formation	J:29085
	increased synaptic depression	J:29086
Syn1^tm1Sud/Syn1^tm1Sud involves: 129S7/SvEvBrd	convulsive seizures	J:15701
Syn1^tm1Sud/Syn1^tm1Sud involves: 129S7/SvEvBrd	enhanced paired-pulse facilitation	J:15701
Syn1^tm2Noh/Syn1^tm2Noh involves: 129S4/SvJae	abnormal CNS synapse formation	J:30400
Syn1^tm2Noh/Syn1^tm2Noh involves: 129S4/SvJae	abnormal synaptic vesicle clustering	J:30400

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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