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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tal1
T cell acute lymphocytic leukemia 1
MGI:98480
82 phenotypes from 10 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tal1Hpt/Tal1+
(C57BL/6J x C3FeLe.B6-a/a)F1 		abnormal coat appearance J:13897
abnormal hair follicle development J:13897
abnormal skin pigmentation J:13897
focal hair loss J:13897
sparse hair J:13897
Tal1Hpt/Tal1+
HPT/Le 		abnormal erythropoiesis J:1780
abnormal hair follicle development J:1780
abnormal hair growth J:1780
abnormal kidney morphology J:1780
abnormal podocyte foot process morphology J:1780
abnormal renal glomerulus morphology J:1780
abnormal skin pigmentation J:1780
alopecia J:1780
anemia J:1780
decreased body size J:1780
decreased hair follicle number J:1780
decreased leukocyte cell number J:1780
enlarged heart J:1780
fused podocyte foot processes J:1780
glomerulosclerosis J:1780
heart left ventricle hypertrophy J:1780
hypertension J:1780
kidney failure J:1780
Tal1Hpt/Tal1Hpt
(C57BL/6J x C3FeLe.B6-a/a)F1 		abnormal coat appearance J:13897
abnormal hair follicle development J:13897
abnormal skin pigmentation J:13897
focal hair loss J:13897
sparse hair J:13897
Tal1Hpt/Tal1Hpt
HPT/Le 		abnormal ectoderm development J:1780
embryonic lethality between implantation and somite formation, complete penetrance J:1780
Tal1tm1(tTA)Bock/Tal1tm1(tTA)Bock
involves: C57BL/6 * DBA/2 		embryonic lethality J:138070
Tal1tm1.1Bgo/Tal1tm1.1Bgo
Not Specified 		abnormal bone marrow cell morphology/development J:203178
normal hematopoietic system phenotype J:203178
increased hematopoietic stem cell number J:203178
Tal1tm1Por/Tal1tm1Por
involves: 129P2/OlaHsd 		abnormal embryonic erythropoiesis J:139179
abnormal erythroid progenitor cell morphology J:139179
abnormal erythropoiesis J:139179
anisocytosis J:139179
decreased embryo size J:139179
decreased hematocrit J:139179
decreased hemoglobin content J:139179
decreased mean corpuscular hemoglobin concentration J:139179
decreased mean corpuscular volume J:139179
decreased survivor rate J:139179
extramedullary hematopoiesis J:139179
increased red blood cell distribution width J:139179
increased spleen weight J:139179
lethality throughout fetal growth and development, incomplete penetrance J:139179
microcytic anemia J:139179
pale yolk sac J:139179
Tal1tm1Sho/Tal1tm1Sho
involves: 129S4/SvJae 		abnormal embryonic hematopoiesis J:23061
abnormal placental labyrinth vasculature morphology J:23061
absent common myeloid progenitor cells J:23061
absent visceral yolk sac blood islands J:23061
anemia J:23061
decreased embryo size J:23061
distended pericardium J:23061
embryo tissue necrosis J:23061
embryonic growth retardation J:23061
embryonic lethality during organogenesis, complete penetrance J:23061
incomplete somite formation J:23061
pallor J:23061
Tal1tm1Wehi/Tal1tm1Wehi
involves: 129S1/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:27458
absent visceral yolk sac blood islands J:27458
absent vitelline blood vessels J:27458
distended pericardium J:27458
embryonic growth arrest J:27458
embryonic growth retardation J:27458
embryonic lethality during organogenesis, complete penetrance J:27458
incomplete embryo turning J:27458
pale yolk sac J:27458
pallor J:27458
skin edema J:27458
Tal1tm2Sho/Tal1tm2Sho
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		anemia J:83215
premature death J:83215
thrombocytopenia J:83215
Tal1tm2Wehi/Tal1tm2Wehi
involves: 129S1/Sv * C57BL/6 		abnormal blood vessel morphology J:58825
abnormal embryonic hematopoiesis J:58825
abnormal heart development J:58825
abnormal vein morphology J:58825
absent visceral yolk sac blood islands J:58825
absent vitelline blood vessels J:58825
anemia J:58825
delayed heart looping J:58825
dilated dorsal aorta J:58825
disorganized yolk sac vascular plexus J:58825
distended pericardium J:58825
embryonic growth arrest J:58825
embryonic lethality during organogenesis, complete penetrance J:58825
hypoxia J:58825
increased neuron apoptosis J:58825
pericardial edema J:58825
Tal1tm3Wehi/Tal1tm2Wehi
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal bone marrow morphology J:81826
abnormal erythropoiesis J:81826
abnormal megakaryocyte morphology J:81826
abnormal megakaryocyte progenitor cell morphology J:81826
abnormal proerythroblast morphology J:81826
abnormal splenic cell ratio J:81826
anemia J:81826
decreased bone marrow cell number J:81826
impaired hematopoiesis J:81826
thrombocytopenia J:81826
Tg(Lck-Tal1)4709Led/0
FVB/N-Tg(Lck-Tal1)4709Led 		abnormal thymus morphology J:36076
enlarged liver J:36076
enlarged spleen J:36076
increased leukemia incidence J:36076
increased lymphoblastic lymphoma incidence J:36076
premature death J:36076
respiratory distress J:36076
ruffled hair J:36076
weight loss J:36076
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory