Tbx2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbx2
T-box 2
MGI:98494

20 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺ involves: 129P2/OlaHsd * NMRI	no abnormal phenotype detected	J:154920
Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc} involves: 129P2/OlaHsd * FVB	polydactyly	J:154920
Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc} involves: 129P2/OlaHsd * NMRI	abnormal palatal mesenchymal cell proliferation	J:154920
	cleft secondary palate	J:154920
	decreased palatal shelf size	J:154920
	delayed palatal shelf elevation	J:154920
	polydactyly	J:154920
Tbx2^tm1Pa/Tbx2^tm1Pa involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal fetal atrioventricular canal morphology	J:93610
	embryonic lethality during organogenesis, incomplete penetrance	J:93610
Tbx2^tm1Pa/Tbx2^tm1Pa involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac * ICR	abnormal cardiovascular development	J:93610
	abnormal cardiovascular system morphology	J:93610
	abnormal fetal atrioventricular canal morphology	J:93610
	abnormal truncus arteriosus septation	J:93610
	conotruncal ridge hypoplasia	J:93610
	decreased atrioventricular cushion size	J:93610
	hydrops fetalis	J:93610
	increased heart ventricle size	J:93610
	lethality throughout fetal growth and development, complete penetrance	J:93610
	pericardial edema	J:93610
	persistent right 6th pharyngeal arch artery	J:93610
	polydactyly	J:93610
Tbx2^tm2.1Vmc/Tbx2^tm2.1Vmc involves: 129S4/SvJaeSor * FVB	no abnormal phenotype detected	J:163063
Tbx2^tm2.2Vmc/Tbx2^tm2.2Vmc involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB	abnormal fetal atrioventricular canal morphology	J:163063
	embryonic lethality during organogenesis, complete penetrance	J:163063
	postaxial polydactyly	J:163063

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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