About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx3
T-box 3
MGI:98495
82 phenotypes from 9 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tbx3em1(IMPC)Mbp/Tbx3+
C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal lymph node morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
decreased locomotor activity J:211773
eye hemorrhage J:211773
increased circulating alkaline phosphatase level J:211773
microphthalmia J:211773
Tbx3em1(IMPC)Mbp/Tbx3em1(IMPC)Mbp
C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
Tbx3tm1.1(cre)Vmc/Tbx3+
involves: 129P2/OlaHsd * FVB/N * NMRI 		no abnormal phenotype detected J:154920
Tbx3tm1.1(cre)Vmc/Tbx3tm1.1(cre)Vmc
involves: 129P2/OlaHsd * FVB 		abnormal limb morphology J:121230
abnormal mammary gland development J:121230
abnormal sinoatrial node morphology J:121230
decreased sinoatrial node size J:121230
embryonic lethality during organogenesis, complete penetrance J:121230
Tbx3tm1.1(cre)Vmc/Tbx3tm1.1(cre)Vmc
involves: 129P2/OlaHsd * FVB/N * NMRI 		abnormal palatal shelf fusion at midline J:154920
cleft secondary palate J:154920
lethality throughout fetal growth and development, complete penetrance J:154920
Tbx3tm1.1Moon/Tbx3+
involves: 129 * C57BL/6 * SJL 		irregular heartbeat J:179977
reduced female fertility J:179977
reduced male fertility J:179977
Tbx3tm1.1Moon/Tbx3tm1.1Moon
involves: 129 * C57BL/6 * SJL 		abnormal heart development J:179977
embryonic lethality, incomplete penetrance J:179977
Tbx3tm1.1Moon/Tbx3tm2Moon
involves: 129 * C57BL/6 * SJL 		abnormal cardiovascular development J:179977
abnormal limb morphology J:179977
atrioventricular block J:179977
decreased heart rate J:179977
normal embryo phenotype J:179977
embryonic lethality during organogenesis, incomplete penetrance J:179977
irregular heartbeat J:179977
lethality throughout fetal growth and development, complete penetrance J:179977
sinoatrial node hypoplasia J:179977
ventricular septal defect J:179977
Tbx3tm1Jcib/Tbx3tm1Jcib
involves: 129S4/SvJae * C57BL/6 		abnormal fetal atrioventricular canal morphology J:129349
abnormal heart looping J:129349
abnormal vitelline vasculature morphology J:129349
decreased body size J:129349
delayed heart looping J:129349
failure of heart looping J:129349
pericardial edema J:129349
short hindlimb J:129349
Tbx3tm1Pa/Tbx3+
either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac) 		abnormal clitoris morphology J:82458
abnormal female reproductive system morphology J:82458
abnormal vagina orifice morphology J:82458
Tbx3tm1Pa/Tbx3tm1Pa
either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac) 		abnormal digit morphology J:82458
abnormal embryonic autopod plate morphology J:82458
abnormal forelimb morphology J:82458
abnormal hindlimb morphology J:82458
abnormal hindlimb zeugopod morphology J:82458
abnormal limb development J:82458
abnormal limb morphology J:82458
abnormal mammary gland bud morphology J:82458
abnormal mammary gland embryonic development J:82458
abnormal pelvic girdle bone morphology J:82458
abnormal ulna morphology J:82458
abnormal visceral yolk sac endoderm morphology J:82458
abnormal vitelline vasculature morphology J:82458
absent carpal bone J:82458
absent mammary gland J:82458
absent metacarpal bones J:82458
absent vitelline blood vessels J:82458
embryonic lethality during organogenesis, incomplete penetrance J:82458
pale yolk sac J:82458
small hindlimb buds J:82458
small liver J:82458
thin apical ectodermal ridge J:82458
Tbx3tm2.1Moon/Tbx3tm2.1Moon
involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL 		abnormal impulse conducting system conduction J:179977
abnormal P wave J:179977
abnormal QRS complex J:179977
abnormal sinus arrhythmia J:179977
absent P wave J:179977
absent PR interval J:179977
atrioventricular block J:179977
decreased heart rate J:179977
increased heart rate variability J:179977
irregular heartbeat J:179977
premature death J:179977
preweaning lethality, incomplete penetrance J:179977
prolonged QRS complex duration J:179977
shortened PR interval J:179977
sinus bradycardia J:179977
Tbx3tm2.1Moon/Tbx3tm2.1Moon
involves: 129 * BALB/cJ * C57BL/6 * SJL 		abnormal cardiovascular development J:179977
abnormal digit morphology J:179977
abnormal inferior vena cava morphology J:179977
absent carpal bone J:179977
absent fibula J:179977
absent tarsus bones J:179977
absent ulna J:179977
atrioventricular block J:179977
decreased heart rate J:179977
edema J:179977
normal embryo phenotype J:179977
increased cardiac muscle contractility J:179977
irregular heartbeat J:179977
oligodactyly J:179977
postnatal lethality, incomplete penetrance J:179977
prenatal lethality, incomplete penetrance J:179977
prolonged QRS complex duration J:179977
sinoatrial node hypoplasia J:179977
ventricular septal defect J:179977
Tbx3tm2Moon/Tbx3+
involves: 129 * C57BL/6 		irregular heartbeat J:179977
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 		abnormal sinus arrhythmia J:179977
atrioventricular block J:179977
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
involves: 129 * C57BL/6 		atrioventricular block J:179977
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
involves: 129 * C57BL/6 		atrioventricular block J:179977
embryonic lethality during organogenesis, incomplete penetrance J:179977
irregular heartbeat J:179977
Tbx3tm3.2Moon/Tbx3tm3.2Moon
involves: 129 * BALB/cJ * C57BL/6 * SJL 		atrioventricular block J:179977
decreased heart rate J:179977
embryonic lethality, complete penetrance J:179977
irregular heartbeat J:179977
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory