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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hnf1a
HNF1 homeobox A
MGI:98504
63 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
involves: 129X1/SvJ * C57BL/6J 		abnormal hepatocyte morphology J:47008
abnormal pancreatic islet morphology J:47008
abnormal reproductive system morphology J:47008
abnormal sexual interaction J:47008
abnormal spermatogenesis J:47008
decreased body size J:47008
decreased circulating insulin level J:47008
decreased circulating insulin-like growth factor I level J:47008
decreased pancreatic beta cell number J:47008
enlarged liver J:47008
hyperglycemia J:47008
increased cholesterol level J:47008
increased circulating growth hormone level J:47008
increased urine glucose level J:47008
infertility J:47008
polyuria J:47008
prenatal lethality, incomplete penetrance J:47008
Hnf1atm1.1Ylee/Hnf1atm2Ylee
involves: 129X1/SvJ * C57BL/6J 		abnormal liver morphology J:81639
decreased body size J:81639
decreased circulating insulin level J:81639
enlarged liver J:81639
hepatic steatosis J:81639
hyperglycemia J:81639
infertility J:81639
Hnf1atm1.1Ylee/Hnf1atm2Ylee
Speer6-ps1Tg(Alb-cre)21Mgn/?
involves: 129X1/SvJ * C57BL/6 * DBA 		decreased circulating insulin level J:81639
normal growth/size/body region phenotype J:81639
normal homeostasis/metabolism phenotype J:81639
hyperglycemia J:81639
normal reproductive system phenotype J:81639
Hnf1atm1Mya/Hnf1atm1Mya
involves: 129S2/SvPas 		abnormal circulating amino acid level J:31627
abnormal energy homeostasis J:31627
abnormal renal glucose reabsorption J:31627
abnormal stomach glandular epithelium morphology J:31627
abnormal urine calcium level J:31627
abnormal urine homeostasis J:31627
absent subcutaneous adipose tissue J:31627
aminoaciduria J:31627
argininuria J:31627
cachexia J:31627
decreased blood uric acid level J:31627
decreased body weight J:31627, J:48230
decreased bone mineral density J:31627
decreased circulating arginine level J:31627
decreased circulating lysine level J:31627
decreased creatinine clearance J:31627
decreased insulin secretion J:48230
decreased liver function J:31627
decreased pancreas weight J:48230
decreased pancreatic beta cell mass J:48230
decreased renal glomerular filtration rate J:31627
enlarged liver J:31627
hepatic steatosis J:31627
hydroxyprolinuria J:31627
increased circulating alanine transaminase level J:31627
increased circulating ammonia level J:31627
increased circulating aspartate transaminase level J:31627
increased circulating bilirubin level J:31627
increased circulating cholesterol level J:31627
increased circulating glucose level J:48230
increased circulating hydroxyproline level J:31627
increased circulating phenylalanine level J:31627
increased hepatocyte proliferation J:31627
increased liver weight J:31627
increased urine glucose level J:31627
increased urine phosphate level J:31627
increased urine uric acid level J:31627
jaundice J:31627
muscular atrophy J:31627
oroticaciduria J:31627
polyphagia J:31627
polyuria J:31627
postnatal growth retardation J:31627
premature death J:31627
prenatal lethality, incomplete penetrance J:31627
small pancreatic islets J:48230
Hnf1atm2Mya/Hnf1atm2Mya
involves: 129S2/SvPas 		abnormal circulating amino acid level J:31627
abnormal energy homeostasis J:31627
abnormal renal glucose reabsorption J:31627
abnormal stomach glandular epithelium morphology J:31627
abnormal urine calcium level J:31627
abnormal urine homeostasis J:31627
absent subcutaneous adipose tissue J:31627
aminoaciduria J:31627
argininuria J:31627
cachexia J:31627
decreased blood uric acid level J:31627
decreased body weight J:31627
decreased bone mineral density J:31627
decreased circulating arginine level J:31627
decreased circulating lysine level J:31627
decreased creatinine clearance J:31627
decreased liver function J:31627
decreased renal glomerular filtration rate J:31627
enlarged liver J:31627
hepatic steatosis J:31627
hydroxyprolinuria J:31627
increased circulating alanine transaminase level J:31627
increased circulating ammonia level J:31627
increased circulating aspartate transaminase level J:31627
increased circulating bilirubin level J:31627
increased circulating cholesterol level J:31627
increased circulating hydroxyproline level J:31627
increased circulating phenylalanine level J:31627
increased hepatocyte proliferation J:31627
increased liver weight J:31627
increased urine glucose level J:31627
increased urine phosphate level J:31627
increased urine uric acid level J:31627
jaundice J:31627
muscular atrophy J:31627
oroticaciduria J:31627
polyphagia J:31627
polyuria J:31627
postnatal growth retardation J:31627
premature death J:31627
prenatal lethality, incomplete penetrance J:31627
Hnf1atm2Ylee/Hnf1atm2Ylee
involves: 129X1/SvJ * C57BL/6J 		infertility J:81639
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory