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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hnf1b
HNF1 homeobox B
MGI:98505
69 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hnf1btm1Ics/Hnf1b+
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129P2/OlaHsd 		abnormal renal tubule morphology J:194051
renal glomerulus cyst J:194051
Hnf1btm1Ics/Hnf1btm1Sce
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129P2/OlaHsd 		abnormal kidney morphology J:194051
abnormal loop of Henle morphology J:194051
abnormal metanephros morphology J:194051
abnormal proximal convoluted tubule morphology J:194051
abnormal renal tubule morphology J:194051
hydronephrosis J:194051
postnatal lethality, complete penetrance J:194051
renal glomerulus cyst J:194051
Hnf1btm1Mya/Hnf1btm1Mya
involves: 129S2/SvPas 		abnormal visceral endoderm morphology J:58080
absent blastocoele J:58080
decreased embryo size J:58080
disorganized embryonic tissue J:58080
disorganized extraembryonic tissue J:58080
embryonic growth arrest J:58080
embryonic lethality between implantation and somite formation, complete penetrance J:58080
failure to gastrulate J:58080
Hnf1btm1Mya/Hnf1btm3Mya
Tg(Alb1-cre)7Gsc/0
involves: 129S2/SvPas * C57BL/6 * FVB/N 		abnormal bile duct physiology J:75935
abnormal cystic duct morphology J:75935
abnormal extrahepatic bile duct morphology J:75935
abnormal gallbladder epithelium morphology J:75935
abnormal hepatobiliary system morphology J:75935
abnormal hepatobiliary system physiology J:75935
abnormal interlobular bile duct morphology J:75935
abnormal intrahepatic bile duct morphology J:75935
abnormal lipid homeostasis J:75935
cachexia J:75935
decreased body size J:75935
decreased body weight J:75935
decreased liver function J:75935
enlarged liver J:75935
hepatic necrosis J:75935
increased circulating bilirubin level J:75935
increased circulating cholesterol level J:75935
increased circulating triglyceride level J:75935
intrahepatic cholestasis J:75935
jaundice J:75935
liver inflammation J:75935
muscular atrophy J:75935
postnatal growth retardation J:75935
premature death J:75935
Hnf1btm1Sce/Hnf1b+
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129P2/OlaHsd 		normal renal/urinary system phenotype J:194051
Hnf1btm1Sce/Hnf1btm1Sce
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2) 		abnormal developmental patterning J:58079
abnormal ectoderm development J:58079
abnormal embryonic epiblast morphology J:58079
abnormal embryonic tissue morphology J:58079
abnormal extraembryonic tissue morphology J:58079
abnormal inner cell mass morphology J:58079
abnormal primitive endoderm morphology J:58079
absent ectoplacental cavity J:58079
absent parietal endoderm J:58079
absent proamniotic cavity J:58079
absent visceral endoderm J:58079
decreased embryo size J:58079
embryonic growth arrest J:58079
embryonic growth retardation J:58079
embryonic lethality between implantation and somite formation, complete penetrance J:58079
Hnf1btm2Ics/Hnf1b+
involves: 129 * C57BL/6N 		abnormal pancreatic duct morphology J:306082
chronic pancreas inflammation J:306082
decreased circulating insulin level J:306082
decreased insulin secretion J:306082
decreased pancreatic acinar cell number J:306082
decreased pancreatic islet number J:306082
normal homeostasis/metabolism phenotype J:306082
hyperglycemia J:306082
impaired glucose tolerance J:306082
increased fasting circulating glucose level J:306082
pancreas fibrosis J:306082
pancreas lipomatosis J:306082
pancreatic acinar hypoplasia J:306082
pancreatic acinar-to-ductal metaplasia J:306082
small pancreatic islets J:306082
Hnf1btm2Mya/Hnf1btm2Mya
involves: 129S2/SvPas 		abnormal extraembryonic endoderm formation J:58080
absent blastocoele J:58080
decreased embryo size J:58080
disorganized embryonic tissue J:58080
disorganized extraembryonic tissue J:58080
embryonic growth arrest J:58080
embryonic lethality between implantation and somite formation, complete penetrance J:58080
failure to gastrulate J:58080
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory