Tcf4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf4
transcription factor 4
MGI:98506

46 phenotypes from 7 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tcf4^em1Bdph/? involves: C57BL/6 * C57BL/6J	abnormal action potential	J:254983
	abnormal brain morphology	J:254983
	decreased anxiety-related response	J:254983
	decreased body weight	J:254983
	decreased brain weight	J:254983
	decreased startle reflex	J:254983
	enhanced long-term potentiation	J:254983
	enhanced NMDA-mediated synaptic currents	J:254983
	impaired spatial learning	J:254983
	increased locomotor activity	J:254983
	increased prepulse inhibition	J:254983
	microcephaly	J:254983
Tcf4^em2Bdph/? involves: C57BL/6 * C57BL/6J	abnormal brain morphology	J:254983
	decreased brain weight	J:254983
	enhanced long-term potentiation	J:254983
	microcephaly	J:254983
Tcf4^tm1.1Hmb/Tcf4⁺ involves: 129P2/OlaHsd * C57BL/6J	increased double-negative T cell number	J:136143
Tcf4^tm1.1Hmb/Tcf4^tm1.1Hmb involves: 129P2/OlaHsd * C57BL/6J	abnormal T cell differentiation	J:136143
	abnormal T cell physiology	J:136143
	normal immune system phenotype	J:136143
	increased double-negative T cell number	J:136143
	postnatal lethality, complete penetrance	J:136143
Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺ C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal retina morphology	J:211773
Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺ involves: C57BL/6N	abnormal corpus callosum morphology	J:265025
	abnormal dentate gyrus morphology	J:265025
	decreased hippocampus volume	J:265025
	thin cerebral cortex	J:265025
Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4^{tm1a(EUCOMM)Wtsi} C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773
Tcf4^tm1Hmb/Tcf4⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺ involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal habituation to a new environment	J:254983
	decreased anxiety-related response	J:254983
	decreased body weight	J:254983
	decreased prepulse inhibition	J:254983
	decreased startle reflex	J:254983
	enhanced long-term potentiation	J:254983
	enhanced NMDA-mediated synaptic currents	J:254983
	impaired spatial learning	J:254983
	increased locomotor activity	J:254983
Tcf4^tm1Hmb/Tcf4⁺ Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal brain morphology	J:254983
	decreased body weight	J:254983
	decreased brain weight	J:254983
	enhanced long-term potentiation	J:254983
	microcephaly	J:254983
Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/? involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal B cell differentiation	J:65236
	decreased double-positive T cell number	J:65236
	decreased thymocyte number	J:65236
	spleen hypoplasia	J:65236
Tcf4^tm1Zhu/Tcf4⁺ involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J	abnormal gait	J:239016
	abnormal long-term spatial reference memory	J:239016
	decreased grip strength	J:239016
	decreased prepulse inhibition	J:239016
	decreased vocalization	J:239016
	enhanced long-term potentiation	J:239016
	impaired balance	J:239016
	impaired contextual conditioning behavior	J:239016
	impaired cued conditioning behavior	J:239016
	impaired spatial learning	J:239016
	increased grooming behavior	J:239016
	increased locomotor activity	J:239016
	increased startle reflex	J:239016
	social withdrawal	J:239016
Tcf4^tm1Zhu/Tcf4^tm1Zhu involves: 129P2/OlaHsd	abnormal brain development	J:125313
Tcf4^tm1Zhu/Tcf4^tm1Zhu involves: 129P2/OlaHsd	neonatal lethality, complete penetrance	J:125313
Tcf4^tm1Zhu/Tcf4^tm1Zhu involves: 129P2/OlaHsd * C57BL/6	decreased pro-B cell number	J:43324
Tcf4^tm1Zhu/Tcf4^tm1Zhu involves: 129P2/OlaHsd * C57BL/6	postnatal lethality, complete penetrance	J:43324
Tg(Thy1-Tcf4)1Mjro/0 B6N.FVB-Tg(Thy1-Tcf4)1Mjro	impaired contextual conditioning behavior	J:202664
Tg(Thy1-Tcf4)1Mjro/0 B6N.FVB-Tg(Thy1-Tcf4)1Mjro	impaired cued conditioning behavior	J:202664
Tg(Thy1-Tcf4)1Mjro/0 involves: C57BL/6N * FVB/N	abnormal associative learning	J:197081
	abnormal prepulse inhibition	J:202664
	impaired contextual conditioning behavior	J:197081, J:202664
	impaired cued conditioning behavior	J:197081, J:202664
	impaired spatial learning	J:202664
	increased thigmotaxis	J:202664
	reduced sensorimotor gating	J:202664

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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