Tcf7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf7
transcription factor 7, T cell specific
MGI:98507

19 phenotypes from 3 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics	abnormal forelimb morphology	J:165965
	abnormal response to tactile stimuli	J:165965
	cataract	J:165965
	decreased CD4-positive, alpha-beta T cell number	J:165965
	decreased T cell number	J:165965
	increased B cell number	J:165965
	increased circulating alkaline phosphatase level	J:165965
	syndactyly	J:165965
Tcf7^tm1Cle/Tcf7^tm1Cle involves: 129P2/OlaHsd	abnormal memory T cell physiology	J:189838
	abnormal T cell differentiation	J:23255
	decreased bone mineral density	J:98430
	decreased CD8-positive, alpha-beta T cell number	J:189838
	decreased double-positive T cell number	J:23255
	decreased single-positive T cell number	J:23255
	decreased T cell number	J:23255
	increased intestinal adenoma incidence	J:57721
	increased mammary adenoacanthoma incidence	J:57721
	increased osteoclast cell number	J:98430
	thymus cortex hypoplasia	J:23255
	thymus hypoplasia	J:23255
Tcf7^tm2Cle/Tcf7^tm2Cle involves: 129P2/OlaHsd	decreased double-positive T cell number	J:23255
	decreased single-positive T cell number	J:23255
	thymus hypoplasia	J:23255

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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