Tcf7 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf7
transcription factor 7, T cell specific
MGI:98507

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Tcf7^tm1Cle/Tcf7^tm1Cle involves: 129P2/OlaHsd * C57BL/6J	increased intestinal adenoma incidence	J:57721
	increased mammary adenoacanthoma incidence	J:57721
	increased salivary gland tumor incidence	J:57721
Ctnnb1^tm1Mmt/Ctnnb1⁺ Tcf7^tm1Cle/Tcf7⁺ involves: 129P2/OlaHsd * 129X1/SvJ	abnormal bone structure	J:98430
Lef1^tm1Hhx/Lef1^tm1Hhx Tcf7^tm1Cle/Tcf7^tm1Cle Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺ Tg(GZMB-cre)1Jcb/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N	abnormal memory T cell physiology	J:189838
	decreased CD8-positive, alpha-beta T cell number	J:189838
	decreased tumor necrosis factor secretion	J:189838
Lef1^tm1Rug/Lef1^tm1Rug Tcf7^tm1Cle/Tcf7^tm1Cle involves: 129P2/OlaHsd * 129S2/SvPas	abnormal allantois morphology	J:54101
	abnormal ectomesenchyme morphology	J:54101
	abnormal embryonic tissue morphology	J:54101
	abnormal extraembryonic tissue morphology	J:54101
	abnormal limb bud morphology	J:54101
	abnormal neural tube morphology	J:54101
	absent apical ectodermal ridge	J:54101
	embryonic lethality during organogenesis, incomplete penetrance	J:54101
	incomplete somite formation	J:54101
	small embryonic telencephalon	J:54101
	small forelimb buds	J:54101
Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle Tg(Vil1-cre/ERT2)23Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal digestive system morphology	J:185753
	abnormal digestive system physiology	J:185753
Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tg(Vil1-cre/ERT2)23Syr/0 involves: 129 * C57BL/6 * DBA/2	normal digestive/alimentary phenotype	J:185753

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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