Tcf3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf3
transcription factor 3
MGI:98510

52 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Tcf3^tm1Mbu/Tcf3^tm1.2Mbu Tg(Vav-BCL2)69Jad/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	decreased pre-B cell number	J:137719
Id1^tm1Zhu/Id1^tm1Zhu Tcf3^tm1Wein/Tcf3^tm1Wein involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	abnormal thymus corticomedullary boundary morphology	J:44278
	absent B cells	J:44278
	arrested B cell differentiation	J:44278
	decreased lymphocyte cell number	J:44278
	increased T cell derived lymphoma incidence	J:44278
	intermingled spleen red and white pulp	J:44278
	neonatal lethality, incomplete penetrance	J:44278
	postnatal growth retardation	J:44278
	postnatal lethality, incomplete penetrance	J:44278
Id2^tm1Yyk/Id2^tm1Yyk Tcf3^tm1Cmu/Tcf3⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	absent axillary lymph nodes	J:125739
	absent brachial lymph nodes	J:125739
	absent inguinal lymph nodes	J:125739
	decreased NK T cell number	J:125739
Id2^tm1Yyk/Id2^tm1Yyk Tcf3^tm1Cmu/Tcf3^tm1Cmu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	decreased B cell number	J:125739
	decreased NK T cell number	J:125739
	normal immune system phenotype	J:125739
	small lymph nodes	J:125739
Id3^tm2.1Cmu/Id3^tm2.1Cmu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJaeSor * C57BL/6 * DBA/2	decreased thymocyte number	J:176462
	normal immune system phenotype	J:176462
Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	abnormal immunoglobulin heavy chain V(D)J recombination	J:137719
	normal immune system phenotype	J:137719
Pax1^un/Pax1⁺ Tcf3^tm1Cmu/Tcf3^tm1Cmu involves: 129P2/OlaHsd * C3H * C57BL/6	abnormal renal/urinary system morphology	J:103567
	abnormal T cell differentiation	J:103567
	abnormal T cell subpopulation ratio	J:103567
	curly tail	J:103567
	infertility	J:103567
	open neural tube	J:103567
	postnatal lethality, incomplete penetrance	J:103567
	spina bifida	J:103567
Pax5^tm3Mbu/Pax5⁺ Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal pro-B cell morphology	J:226241
	arrested B cell differentiation	J:226241
	decreased immature B cell number	J:226241
	increased B cell acute lymphoblastic leukemia incidence	J:226241
Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:226241
	abnormal pro-B cell differentiation	J:226241
	abnormal pro-B cell morphology	J:226241
	anemia	J:226241
	arrested B cell differentiation	J:226241
	decreased B cell number	J:226241
	decreased immature B cell number	J:226241
	enlarged liver	J:226241
	enlarged lymph nodes	J:226241
	enlarged spleen	J:226241
	increased B cell acute lymphoblastic leukemia incidence	J:226241
	increased leukocyte cell number	J:226241
	thrombocytopenia	J:226241
Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * C57BL/6J * CBA/J	anemia	J:226241
	arrested B cell differentiation	J:226241
	decreased B cell number	J:226241
	decreased immature B cell number	J:226241
	enlarged liver	J:226241
	enlarged lymph nodes	J:226241
	enlarged spleen	J:226241
	increased B cell acute lymphoblastic leukemia incidence	J:226241
	increased leukocyte cell number	J:226241
	thrombocytopenia	J:226241
Tcf3^tm1(PBX1)Mlc/Tcf3⁺ Cd79a^tm1(cre)Reth/Cd79a⁺ involves: BALB/c * C57BL/6	anemia	J:226241
	arrested B cell differentiation	J:226241
	decreased B cell number	J:226241
	decreased immature B cell number	J:226241
	enlarged liver	J:226241
	enlarged lymph nodes	J:226241
	enlarged spleen	J:226241
	increased B cell acute lymphoblastic leukemia incidence	J:226241
	increased leukocyte cell number	J:226241
	thrombocytopenia	J:226241
Tcf3^{tm1(TCF3/HLF)Homy}/Tcf3⁺ Tg(Emu-Zfp521)1Homy/0 Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	increased leukemia incidence	J:160392
	premature death	J:160392
Tcf3^tm1Xhsu/Tcf3^tm1Xhsu Tg(Lck-Stat5b)1Mafa/0 involves: 129X1/SvJ C57BL/6 * FVB/N	increased B cell proliferation	J:132669
Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0 Tg(TcrAND)53Hed/0 involves: 129S4/SvJae * C57BL/6 * SJL	normal immune system phenotype	J:75746
	normal neoplasm	J:75746
Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Wein/Tcf3⁺ involves: 129P2/OlaHsd	decreased pro-B cell number	J:43324
	postnatal growth retardation	J:43324
	postnatal lethality, incomplete penetrance	J:43324
Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Zhu/Tcf3⁺ involves: 129P2/OlaHsd	normal nervous system phenotype	J:125313
Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm1Wein/Tcf3⁺ involves: 129S4/SvJaeSor	decreased pro-B cell number	J:43324
	postnatal growth retardation	J:43324
	postnatal lethality, incomplete penetrance	J:43324
Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL	abnormal T cell differentiation	J:75746
	increased double-negative T cell number	J:75746
	increased single-positive T cell number	J:75746
Tcf12^tm3Zhu/Tcf12^tm3Zhu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	abnormal CD8-positive, alpha beta T cell morphology	J:129171
	abnormal T cell differentiation	J:129171
	decreased CD4-positive, alpha-beta T cell number	J:129171
	increased CD8-positive, alpha-beta T cell number	J:129171
Tcf12^tm3Zhu/Tcf12^tm3Zhu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0 involves: 129S4/SvJae * C57BL/6 * SJL/J	decreased double-positive T cell number	J:129570
	decreased T cell number	J:129570
	increased double-negative T cell number	J:129570
	increased T cell proliferation	J:129570
	thymus hypoplasia	J:129570

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