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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tcra
T cell receptor alpha chain
MGI:98553
77 phenotypes from 11 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
TcraLn1Ogu/Tcra+
involves: 129/Sv * C57BL/6 		abnormal cytokine secretion J:152041
abnormal liver morphology J:152041
abnormal NK T cell morphology J:152041
abnormal T cell subpopulation ratio J:152041
decreased IgG2a level J:152041
decreased splenocyte number J:152041
decreased thymocyte number J:152041
increased IgG1 level J:152041
increased interferon-gamma secretion J:152041
increased interleukin-2 secretion J:152041
increased interleukin-4 secretion J:152041
increased interleukin-10 secretion J:152041
increased NK T cell number J:152041
TcraLn3Jae/Tcra+
B6.Cg-TcraLn3Jae 		abnormal double-negative T cell morphology J:143006
decreased CD4-positive, alpha-beta T cell number J:143006
decreased double-positive T cell number J:143006
increased CD8-positive, alpha-beta T cell number J:143006
thymus hypoplasia J:143006
Tcratm1Cgn/Tcratm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal CD4-positive, alpha beta T cell morphology J:79298
abnormal CD8-positive, alpha beta T cell morphology J:79298
abnormal memory T cell morphology J:79298
abnormal T cell morphology J:79298
Tcratm1Cgn/Tcratm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		normal immune system phenotype J:201417
Tcratm1Cgn/Tcratm1Mass
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal T cell physiology J:201417
increased T cell number J:201417
Tcratm1Mass/Tcra+
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal NK T cell morphology J:201417
decreased NK cell number J:201417
increased NK T cell number J:201417
Tcratm1Mass/Tcra+
Tg(Nes-cre)Wme/0
involves: C57BL/6 * CBA 		abnormal positive T cell selection J:201417
decreased NK T cell number J:201417
decreased thymocyte number J:201417
increased double-negative T cell number J:201417
Tcratm1Mass/Tcratm1Mass
involves: C57BL/6 		arrested T cell differentiation J:201417
Tcratm1Mjo/Tcra+
NOD.129P2-Tcratm1Mjo 		abnormal T cell physiology J:108590
decreased susceptibility to autoimmune diabetes J:108590
Tcratm1Mjo/Tcra+
SJL.129P2-Tcratm1Mjo 		normal immune system phenotype J:108590
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd 		abnormal colon morphology J:37699
abnormal intestinal mucosa morphology J:37699
abnormal neuron proliferation J:170591
colitis J:37699
decreased T cell proliferation J:110898
diarrhea J:37699
enlarged mesenteric lymph nodes J:110898
enlarged spleen J:110898
increased activated T cell number J:110898
increased gamma-delta T cell number J:110898
increased T cell number J:110898
rectal prolapse J:37699
spleen hyperplasia J:110898
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * BALB/c 		abnormal immune system organ morphology J:1292
abnormal splenic cell ratio J:1292
abnormal T cell morphology J:1292
abnormal thymus cortex morphology J:1292
absent thymus medulla J:1292
enlarged thymus cortex J:1292
increased activated T cell number J:111129
increased anti-double stranded DNA antibody level J:111129
increased anti-nuclear antigen antibody level J:111129
increased autoantibody level J:111129
increased B cell number J:111129
increased IgE level J:111129
increased IgG1 level J:111129
increased immunoglobulin level J:111129
small Peyer's patches J:1292
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * MRL 		abnormal kidney morphology J:45448
increased urine protein level J:45448
Tcratm1Mjo/Tcratm1Mjo
NOD.129P2-Tcratm1Mjo 		increased activated T cell number J:52940
Tcratm1Mom/Tcratm1Mom
B6.129S2-Tcratm1Mom 		abnormal large intestine morphology J:135597
abnormal response to transplant J:91742
colitis J:135597
increased mature gamma-delta T cell number J:135597
increased susceptibility to bacterial infection J:106241
rectal prolapse J:135597
Tcratm1Mom/Tcratm1Mom
involves: 129S2/SvPas 		absent T cells J:88620
Tcratm1Mom/Tcratm1Mom
involves: 129S2/SvPas * C57BL/6 		abnormal intestinal goblet cell morphology J:15221
abnormal respiratory system morphology J:119344
abnormal response to infection J:119344
arrested T cell differentiation J:3206
chronic diarrhea J:15221
colitis J:15221
crypts of Lieberkuhn abscesses J:15221
decreased CD4-positive, alpha-beta T cell number J:3206
decreased CD8-positive, alpha-beta T cell number J:3206
decreased IgG level J:119344
increased gamma-delta intraepithelial T cell number J:15221
intestinal ulcer J:15221
premature death J:15221
rectal prolapse J:15221
Tcratm1Mom/Tcratm1Mom
Tg(TcraAV19AJ33)1Shima/?
involves: 129S2/SvPas * C57BL/6 		abnormal NK T cell morphology J:140924
abnormal NK T cell physiology J:140924
Tcratm1Slek/Tcratm1Slek
Not Specified 		normal immune system phenotype J:101719
Tg(Tcra2B4)1Mmd/?
involves: C3H/HeJ * C57BL/6 		abnormal thymus cell ratio J:92992
decreased CD4-positive, alpha-beta T cell number J:92992
decreased double-positive T cell number J:92992
decreased thymocyte number J:92992
increased double-negative T cell number J:92992
increased lymphoma incidence J:92992
Tg(TcraAI4)1Dvs/0
NOD-Tg(TcraAI4)1Dvs 		abnormal CD4-positive, alpha beta T cell morphology J:93553
increased susceptibility to autoimmune diabetes J:93553
Tg(TcraAV19AJ33)1Shima/?
involves: 129S4/SvJae * C57BL/6 		abnormal NK T cell morphology J:112657
abnormal NK T cell physiology J:112657
decreased susceptibility to experimental autoimmune encephalomyelitis J:112657
Tg(TcraDN32D3)#Alhn/0
involves: NOD 		decreased NK cell number J:201417
decreased thymocyte number J:201417
increased double-negative T cell number J:201417
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory