Tek Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tek
TEK receptor tyrosine kinase
MGI:98664

21 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tek^{tm1.1(icre/Esr1)Hrr}/Tek^{tm1.1(icre/Esr1)Hrr} involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:219867
Tek^tm1.1Vlcg/Tek^tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Tek^{tm1b(EUCOMM)Hmgu}/Tek^{tm1b(EUCOMM)Hmgu} C57BL/6N-Tek^{tm1b(EUCOMM)Hmgu}/BayMmucd	abnormal pericardium morphology	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Tek^tm1Dmt/Tek^tm1Dmt involves: 129S1/Sv * 129X1/SvJ	normal embryo phenotype	J:125783
Tek^tm1Dmt/Tek^tm1Dmt involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal definitive hematopoiesis	J:99096
	abnormal heart development	J:99096
	abnormal pericyte morphology	J:99096
	abnormal vascular endothelial cell morphology	J:99096
	abnormal vitelline vascular remodeling	J:99096
	absent myocardial trabeculae	J:99096
	embryonic lethality during organogenesis, complete penetrance	J:99096
	failure of vascular branching	J:99096
	intracranial hemorrhage	J:99096
Tek^tm1Sato/Tek^tm1Sato either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)	abnormal angiogenesis	J:26844
	abnormal vascular branching morphogenesis	J:26844
	abnormal vitelline vasculature morphology	J:26844
	embryonic growth retardation	J:26844
	embryonic lethality during organogenesis, complete penetrance	J:26844
Tek^tm1Sato/Tek^tm1Sato involves: 129S1/Sv * C57BL/6J	abnormal angiogenesis	J:79305
	abnormal blood vessel morphology	J:79305
	abnormal heart development	J:79305
	abnormal vascular endothelial cell morphology	J:79305
	absent trabeculae carneae	J:79305
	embryo tissue necrosis	J:79305
	failure of vascular branching	J:79305

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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