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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ift88
intraflagellar transport 88
MGI:98715
111 phenotypes from 7 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ift88cbbs/Ift88cbbs
B6.Cg-Mapttm1(EGFP)Klt Ift88cbbs 		abnormal cardiovascular development J:142500
abnormal coronary sinus morphology J:142500
abnormal forebrain morphology J:142500
abnormal lung development J:142500
abnormal nervous system development J:142500
abnormal telencephalon morphology J:142500
absent pulmonary artery J:142500
anomalous pulmonary venous connection J:142500
atrial septal defect J:142500
coloboma J:142500
common atrium J:142500
embryonic lethality during organogenesis, incomplete penetrance J:142500
exencephaly J:142500
lethality throughout fetal growth and development, incomplete penetrance J:142500
normal nervous system phenotype J:142500
persistent truncus arteriosus J:142500
polydactyly J:142500
pulmonary hypoplasia J:142500
normal respiratory system phenotype J:142500
ventricular septal defect J:142500
Ift88cbbs/Ift88tm1.1Bky
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal direction of heart looping J:142500
abnormal lateral ganglionic eminence morphology J:142500
abnormal medial ganglionic eminence morphology J:142500
abnormal nervous system development J:142500
abnormal telencephalon morphology J:142500
coloboma J:142500
midbrain hyperplasia J:142500
Ift88fxo/Ift88fxo
C3.B6J-Ift88fxo 		abnormal floor plate morphology J:86437
abnormal midbrain morphology J:86437
embryonic lethality during organogenesis, complete penetrance J:86437
polydactyly J:86437
Ift88fxo/Ift88fxo
involves: C3HeB/FeJ * C57BL/6J 		abnormal diencephalon morphology J:98216
abnormal left-right axis patterning J:98216
absent floor plate J:98216
embryonic lethality during organogenesis, complete penetrance J:98216
polydactyly J:98216
Ift88fxo/Ift88tm1Rpw
involves: 129/Sv * C3HeB/FeJ * C57BL/6J 		abnormal cranial flexure morphology J:86437
abnormal floor plate morphology J:86437
embryonic growth arrest J:86437
embryonic lethality during organogenesis, complete penetrance J:86437
preaxial polydactyly J:86437
Ift88Tg737Rpw/Ift88Tg737Rpw
C3.FVB-Ift88Tg737Rpw 		abnormal bile duct morphology J:18508, J:73583
abnormal oval cell physiology J:18508
abnormal pancreatic duct morphology J:73583
absent oval cells J:73583
decreased urine osmolality J:73583
increased bile salt level J:73583
increased circulating alkaline phosphatase level J:73583
kidney cyst J:18508, J:73583
liver fibrosis J:18508, J:73583
polydactyly J:18508
Ift88Tg737Rpw/Ift88Tg737Rpw
FVB/N-Ift88Tg737Rpw 		abnormal bile duct morphology J:18508, J:37149
abnormal liver parenchyma morphology J:18508, J:37149
abnormal pancreas physiology J:95813
abnormal pancreas secretion J:95813
abnormal pancreatic acinus morphology J:95813
abnormal pancreatic duct morphology J:73583
decreased circulating glucose level J:95813
decreased pancreatic acinar cell number J:73583
decreased pancreatic primary cilium length J:95813
decreased pancreatic primary cilium number J:95813
decreased urine osmolality J:73583
disheveled coat J:18508
enlarged kidney J:18508
impaired glucose tolerance J:95813
increased bile salt level J:73583
increased circulating alkaline phosphatase level J:73583
liver fibrosis J:18508, J:37149
pancreas cyst J:73583, J:95813
polycystic kidney J:18508, J:73583
polydactyly J:18508
postnatal growth retardation J:18508
postnatal lethality, incomplete penetrance J:18508, J:37149
small pancreas J:95813
Ift88Tg737Rpw/Ift88Tg737Rpw
involves: 129/Sv * FVB/N 		abnormal bile duct morphology J:62025
abnormal pancreatic duct morphology J:62025
dilated proximal convoluted tubule J:62025
kidney cyst J:62025
pancreatic acinar cell atrophy J:62025
polydactyly J:62025
Ift88Tg737Rpw/Ift88Tg737Rpw
involves: C3H * FVB/N 		abnormal liver morphology J:73583
abnormal pancreas morphology J:73583
kidney cyst J:73583
Ift88Tg737Rpw/Ift88Tg737Rpw
involves: FVB/N 		abnormal carpal bone morphology J:83305
abnormal coronal suture morphology J:83305
abnormal inner ear morphology J:83305
abnormal limb bud morphology J:83305
abnormal long bone morphology J:83305
abnormal pancreas morphology J:90990
abnormal pancreas secretion J:90990
abnormal pancreatic acinar cell morphology J:90990
abnormal pancreatic duct morphology J:90990
abnormal phalanx morphology J:83305
abnormal renal tubule epithelial cell primary cilium morphology J:65500
abnormal tarsal bone morphology J:83305
cleft secondary palate J:83305
decreased pancreatic primary cilium length J:90990
decreased pancreatic primary cilium number J:90990
pancreas cyst J:90990
polydactyly J:83305
small pancreas J:90990
supernumerary molars J:83305
Ift88Tg737Rpw/Ift88tm1Rpw
involves: 129/Sv * FVB/N 		abnormal bile duct morphology J:62025
abnormal liver morphology J:62025
abnormal pancreatic duct morphology J:62025
dilated proximal convoluted tubule J:62025
kidney cyst J:62025
pancreatic acinar cell atrophy J:62025
preaxial polydactyly J:62025
Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J 		abnormal embryo size J:211773
abnormal embryo turning J:211773
embryonic growth retardation J:211773
preweaning lethality, complete penetrance J:211773
Ift88tm1.1Bky/Ift88tm1.1Bky
involves: 129P2/OlaHsd 		abnormal heart looping J:297055
absent embryonic cilia J:297055
embryonic lethality prior to organogenesis J:297055
pericardial effusion J:297055
Ift88tm1Bky/Ift88tm1.1Bky
involves: 129P2/OlaHsd 		abnormal limb bud morphology J:117033
Ift88tm1Bky/Ift88tm1.1Bky
Tg(Prrx1-cre)1Cjt/?
involves: 129P2/OlaHsd * C57BL/6J * SJL/J 		abnormal bone mineralization J:117033
abnormal chondrocyte morphology J:117033
abnormal limb bud morphology J:117033
abnormal osteoblast morphology J:117033
abnormal perichondrium morphology J:117033
abnormal skeleton development J:117033
decreased body size J:117033
decreased length of long bones J:117033
decreased long bone epiphyseal plate size J:117033
disorganized long bone epiphyseal plate J:117033
polydactyly J:117033
short limbs J:117033
Ift88tm1Bky/Ift88tm1Bky
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal mitral valve cusp morphology J:291454
abnormal mitral valve morphology J:291454
abnormal motile cilium morphology J:291454
Ift88tm1Bky/Ift88tm1Bky
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129P2/OlaHsd 		abnormal palatal rugae morphology J:281425
Ift88tm1Bky/Ift88tm1Bky
Tg(Col1a1-cre)1Bek/0
involves: 129 * 129P2/OlaHsd * CD-1 		atrioventricular septal defect J:308860
complete atrioventricular septal defect J:308860
double outlet right ventricle J:308860
Ift88tm1Bky/Ift88tm1Bky
Tg(Col2a1-cre)1Bhr/?
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal long bone epiphyseal plate morphology J:121342
disproportionate dwarf J:121342
Ift88tm1Bky/Ift88tm1Rpw
Tg(Col1a1-cre)1Bek/0
involves: 129 * 129P2/OlaHsd * CD-1 		abnormal dorsal mesocardium morphology J:308860
anomalous pulmonary venous connection J:308860
atrioventricular septal defect J:308860
complete atrioventricular septal defect J:308860
double outlet right ventricle J:308860
persistent truncus arteriosus J:308860
Ift88tm1Rpw/Ift88tm1.1Bky
involves: 129 * 129P2/OlaHsd 		abnormal neural tube morphology J:117033
distended pericardium J:117033
open neural tube J:117033
Ift88tm1Rpw/Ift88tm1Rpw
FVB.129-Ift88tm1Rpw 		abnormal direction of heart looping J:62025
abnormal forebrain development J:62025
abnormal hindbrain development J:62025
abnormal left-right axis patterning J:62025
abnormal midbrain development J:62025
abnormal pharyngeal arch morphology J:62025
absent embryonic cilia J:62025
broad limb buds J:62025
distended pericardium J:62025
embryonic growth retardation J:62025
embryonic lethality during organogenesis, complete penetrance J:62025
kinked neural tube J:62025
wavy neural tube J:62025
Ift88tm1Rpw/Ift88tm1Rpw
involves: 129 		abnormal limb bud morphology J:83305
polydactyly J:83305
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory