About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725
145 phenotypes from 8 alleles in 17 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal regulatory T cell physiology J:204761
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		decreased Langerhans cell number J:126147
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal colon morphology J:123547
abnormal crypts of Lieberkuhn morphology J:123547
abnormal hepatocyte morphology J:123547
abnormal inflammatory response J:123547
abnormal interferon level J:123547
abnormal interleukin level J:123547
abnormal intestinal epithelium morphology J:123547
abnormal lung morphology J:123547
abnormal T cell activation J:123547
abnormal T cell differentiation J:123547
abnormal T-helper 17 cell differentiation J:169839
cachexia J:123547
colitis J:123547
crypts of Lieberkuhn abscesses J:123547
decreased susceptibility to experimental autoimmune encephalomyelitis J:123547
diarrhea J:123547
increased anti-double stranded DNA antibody level J:123547
increased anti-nuclear antigen antibody level J:123547
increased T cell proliferation J:123547
premature death J:123547
renal glomerular immunoglobulin deposits J:123547
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal enterocyte proliferation J:169839
abnormal T cell differentiation J:169839
cachexia J:169839
colitis J:169839
decreased susceptibility to experimental autoimmune encephalomyelitis J:169839
decreased T-helper 17 cell number J:169839
increased regulatory T cell number J:169839
increased T-helper 1 cell number J:169839
liver inflammation J:169839
lung inflammation J:169839
Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA 		abnormal immune system organ morphology J:150024
abnormal T cell activation J:150024
abnormal T cell subpopulation ratio J:150024
decreased spleen weight J:150024
decreased thymus weight J:150024
increased inflammatory response J:150024
increased interferon-gamma secretion J:150024
increased interleukin-2 secretion J:150024
lung inflammation J:150024
salivary gland inflammation J:150024
spleen hypoplasia J:150024
thymus hypoplasia J:150024
weight loss J:150024
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone ossification J:204892
abnormal enamel morphology J:204892
abnormal incisor color J:204892
abnormal incisor morphology J:204892
abnormal T cell morphology J:204892
abnormal tooth attrition J:204892
abnormal tooth mineralization J:204892
abnormal tooth morphology J:204892
ameloblast degeneration J:204892
normal craniofacial phenotype J:204892
decreased body height J:204892
decreased body weight J:204892
decreased circulating insulin level J:204892
decreased circulating leptin level J:204892
decreased osteoblast cell number J:204892
decreased subcutaneous adipose tissue amount J:204892
decreased total body fat amount J:204892
decreased white fat cell size J:204892
normal immune system phenotype J:204892
improved glucose tolerance J:204892
increased food intake J:204892
increased monocyte cell number J:204892
increased regulatory T cell number J:204892
infertility J:204892
kyphosis J:204892
malocclusion J:204892
misaligned incisors J:204892
normal mortality/aging J:204892
premature death J:204892
Tgfb1tm1Doe/Tgfb1+
involves: 129S2/SvPas * CF-1 		abnormal physiological response to xenobiotic J:137529
increased circulating creatinine level J:137529
increased susceptibility to kidney reperfusion injury J:137529
renal tubular necrosis J:137529
Tgfb1tm1Doe/Tgfb1tm1Doe
C.129S2-Tgfb1tm1Doe 		decreased CD4-positive, alpha-beta T cell number J:69346
heart inflammation J:69346
hepatic necrosis J:69346
increased CD4-positive, alpha-beta T cell number J:69346
increased circulating alanine transaminase level J:69346
increased interferon-gamma secretion J:69346
increased T-helper 1 cell number J:69346
liver inflammation J:69346
postnatal lethality, incomplete penetrance J:69346
prenatal lethality, incomplete penetrance J:69346
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas 		normal nervous system phenotype J:117465
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * BALB/c * CF-1 		heart inflammation J:69346
increased circulating alanine transaminase level J:69346
increased interferon-gamma secretion J:69346
liver inflammation J:69346
normal liver/biliary system phenotype J:69346
lung inflammation J:69346
postnatal lethality, complete penetrance J:69346
prenatal lethality, incomplete penetrance J:69346
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * CF-1 		abnormal diaphragm morphology J:2892
abnormal inflammatory response J:2892
abnormal Peyer's patch germinal center morphology J:2892
brain inflammation J:2892
cachexia J:2892
conjunctivitis J:2892
decreased Peyer's patch number J:2892
diaphragmitis J:2892
disheveled coat J:2892
enlarged lymph nodes J:2892
eye inflammation J:2892
gastric necrosis J:2892
gastric ulcer J:2892
heart inflammation J:2892
normal homeostasis/metabolism phenotype J:2892
hunched posture J:2892
increased leukocyte cell number J:2892
lacrimal gland inflammation J:2892
lethality at weaning, complete penetrance J:2892, J:99033
liver inflammation J:2892
lung inflammation J:2892
multifocal hepatic necrosis J:2892
myocardium necrosis J:2892
myositis J:2892
pancreas inflammation J:2892
salivary gland inflammation J:2892
skin inflammation J:2892
small spleen J:2892
stomach inflammation J:2892
Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/?
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA 		lung inflammation J:150024
salivary gland inflammation J:150024
Tgfb1tm1N/Tgfb1+
involves: 129S/SvEv * C57BL/6J * NIH/Ola 		embryonic lethality during organogenesis, incomplete penetrance J:26913
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv 		abnormal atrial thrombosis J:50848
abnormal immune system physiology J:120085
abnormal liver morphology J:120085
abnormal lung morphology J:120085
absent Langerhans cell J:120085
atrial endocarditis J:50848
cachexia J:50848
colonic necrosis J:50848
disheveled coat J:50848
gastric necrosis J:50848
increased inflammatory response J:50848
interstitial pneumonia J:50848
lymph node inflammation J:50848
myocarditis J:50848
pancreas inflammation J:50848
pericarditis J:50848
phlebitis J:50848
premature death J:50848
prenatal lethality, incomplete penetrance J:50848
salivary gland inflammation J:50848
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv * C57BL/6J * NIH/Ola 		abnormal embryonic erythropoiesis J:26913
abnormal embryonic hematopoiesis J:26913
abnormal extraembryonic tissue morphology J:26913
abnormal heart development J:26913
abnormal vascular endothelial cell differentiation J:26913
abnormal vitelline vasculature morphology J:26913
absent vitelline blood vessels J:26913
delayed hepatic development J:26913
edema J:26913
embryo tissue necrosis J:26913
embryonic growth retardation J:26913
embryonic lethality during organogenesis, incomplete penetrance J:26913
failure of chorioallantoic fusion J:26913
lethality throughout fetal growth and development, incomplete penetrance J:26913
open neural tube J:26913
pale yolk sac J:26913
postnatal lethality J:68448
postnatal lethality, incomplete penetrance J:26913
Tgfb1tm1Rif/Tgfb1tm1Rif
either: (involves: 129) or (involves: 129S/SvEv * C57BL/6) 		abnormal enterocyte morphology J:142353
absent Langerhans cell J:142353
cecum inflammation J:142353
decreased body weight J:142353
heart inflammation J:142353
increased anal adenocarcinoma incidence J:142353
increased colon adenocarcinoma incidence J:142353
increased gastric adenocarcinoma incidence J:142353
increased inflammatory response J:142353
increased large intestine adenocarcinoma incidence J:142353
increased rectum adenocarcinoma incidence J:142353
increased stomach tumor incidence J:142353
increased tumor incidence J:142353
large intestinal inflammation J:142353
lung inflammation J:142353
premature death J:142353
proctitis J:142353
small intestinal inflammation J:142353
stomach inflammation J:142353
Tgfb1tm1Rif/Tgfb1tm1Rif
Not Specified 		abnormal immune system physiology J:141786
Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		decreased Langerhans cell number J:126147
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD 		increased regulatory T cell number J:196160
increased T-helper 1 cell number J:196160
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory