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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725
145 phenotypes from 8 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal regulatory T cell physiology J:204761
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		decreased Langerhans cell number J:126147
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal colon morphology J:123547
abnormal crypts of Lieberkuhn morphology J:123547
abnormal hepatocyte morphology J:123547
abnormal inflammatory response J:123547
abnormal interferon level J:123547
abnormal interleukin level J:123547
abnormal intestinal epithelium morphology J:123547
abnormal lung morphology J:123547
abnormal T cell activation J:123547
abnormal T cell differentiation J:123547
abnormal T-helper 17 cell differentiation J:169839
cachexia J:123547
colitis J:123547
crypts of Lieberkuhn abscesses J:123547
decreased susceptibility to experimental autoimmune encephalomyelitis J:123547
diarrhea J:123547
increased anti-double stranded DNA antibody level J:123547
increased anti-nuclear antigen antibody level J:123547
increased T cell proliferation J:123547
premature death J:123547
renal glomerular immunoglobulin deposits J:123547
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal enterocyte proliferation J:169839
abnormal T cell differentiation J:169839
cachexia J:169839
colitis J:169839
decreased susceptibility to experimental autoimmune encephalomyelitis J:169839
decreased T-helper 17 cell number J:169839
increased regulatory T cell number J:169839
increased T-helper 1 cell number J:169839
liver inflammation J:169839
lung inflammation J:169839
Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA 		abnormal immune system organ morphology J:150024
abnormal T cell activation J:150024
abnormal T cell subpopulation ratio J:150024
decreased spleen weight J:150024
decreased thymus weight J:150024
increased inflammatory response J:150024
increased interferon-gamma secretion J:150024
increased interleukin-2 secretion J:150024
lung inflammation J:150024
salivary gland inflammation J:150024
spleen hypoplasia J:150024
thymus hypoplasia J:150024
weight loss J:150024
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone ossification J:204892
abnormal enamel morphology J:204892
abnormal incisor color J:204892
abnormal incisor morphology J:204892
abnormal T cell morphology J:204892
abnormal tooth attrition J:204892
abnormal tooth mineralization J:204892
abnormal tooth morphology J:204892
ameloblast degeneration J:204892
normal craniofacial phenotype J:204892
decreased body height J:204892
decreased body weight J:204892
decreased circulating insulin level J:204892
decreased circulating leptin level J:204892
decreased osteoblast cell number J:204892
decreased subcutaneous adipose tissue amount J:204892
decreased total body fat amount J:204892
decreased white fat cell size J:204892
normal immune system phenotype J:204892
improved glucose tolerance J:204892
increased food intake J:204892
increased monocyte cell number J:204892
increased regulatory T cell number J:204892
infertility J:204892
kyphosis J:204892
malocclusion J:204892
misaligned incisors J:204892
normal mortality/aging J:204892
premature death J:204892
Tgfb1tm1Doe/Tgfb1+
involves: 129S2/SvPas * CF-1 		abnormal physiological response to xenobiotic J:137529
increased circulating creatinine level J:137529
increased susceptibility to kidney reperfusion injury J:137529
renal tubular necrosis J:137529
Tgfb1tm1Doe/Tgfb1tm1Doe
C.129S2-Tgfb1tm1Doe 		decreased CD4-positive, alpha-beta T cell number J:69346
heart inflammation J:69346
hepatic necrosis J:69346
increased CD4-positive, alpha-beta T cell number J:69346
increased circulating alanine transaminase level J:69346
increased interferon-gamma secretion J:69346
increased T-helper 1 cell number J:69346
liver inflammation J:69346
postnatal lethality, incomplete penetrance J:69346
prenatal lethality, incomplete penetrance J:69346
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas 		normal nervous system phenotype J:117465
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * BALB/c * CF-1 		heart inflammation J:69346
increased circulating alanine transaminase level J:69346
increased interferon-gamma secretion J:69346
liver inflammation J:69346
normal liver/biliary system phenotype J:69346
lung inflammation J:69346
postnatal lethality, complete penetrance J:69346
prenatal lethality, incomplete penetrance J:69346
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * CF-1 		abnormal diaphragm morphology J:2892
abnormal inflammatory response J:2892
abnormal Peyer's patch germinal center morphology J:2892
brain inflammation J:2892
cachexia J:2892
conjunctivitis J:2892
decreased Peyer's patch number J:2892
diaphragmitis J:2892
disheveled coat J:2892
enlarged lymph nodes J:2892
eye inflammation J:2892
gastric necrosis J:2892
gastric ulcer J:2892
heart inflammation J:2892
normal homeostasis/metabolism phenotype J:2892
hunched posture J:2892
increased leukocyte cell number J:2892
lacrimal gland inflammation J:2892
lethality at weaning, complete penetrance J:2892, J:99033
liver inflammation J:2892
lung inflammation J:2892
multifocal hepatic necrosis J:2892
myocardium necrosis J:2892
myositis J:2892
pancreas inflammation J:2892
salivary gland inflammation J:2892
skin inflammation J:2892
small spleen J:2892
stomach inflammation J:2892
Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/?
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA 		lung inflammation J:150024
salivary gland inflammation J:150024
Tgfb1tm1N/Tgfb1+
involves: 129S/SvEv * C57BL/6J * NIH/Ola 		embryonic lethality during organogenesis, incomplete penetrance J:26913
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv 		abnormal atrial thrombosis J:50848
abnormal immune system physiology J:120085
abnormal liver morphology J:120085
abnormal lung morphology J:120085
absent Langerhans cell J:120085
atrial endocarditis J:50848
cachexia J:50848
colonic necrosis J:50848
disheveled coat J:50848
gastric necrosis J:50848
increased inflammatory response J:50848
interstitial pneumonia J:50848
lymph node inflammation J:50848
myocarditis J:50848
pancreas inflammation J:50848
pericarditis J:50848
phlebitis J:50848
premature death J:50848
prenatal lethality, incomplete penetrance J:50848
salivary gland inflammation J:50848
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv * C57BL/6J * NIH/Ola 		abnormal embryonic erythropoiesis J:26913
abnormal embryonic hematopoiesis J:26913
abnormal extraembryonic tissue morphology J:26913
abnormal heart development J:26913
abnormal vascular endothelial cell differentiation J:26913
abnormal vitelline vasculature morphology J:26913
absent vitelline blood vessels J:26913
delayed hepatic development J:26913
edema J:26913
embryo tissue necrosis J:26913
embryonic growth retardation J:26913
embryonic lethality during organogenesis, incomplete penetrance J:26913
failure of chorioallantoic fusion J:26913
lethality throughout fetal growth and development, incomplete penetrance J:26913
open neural tube J:26913
pale yolk sac J:26913
postnatal lethality J:68448
postnatal lethality, incomplete penetrance J:26913
Tgfb1tm1Rif/Tgfb1tm1Rif
either: (involves: 129) or (involves: 129S/SvEv * C57BL/6) 		abnormal enterocyte morphology J:142353
absent Langerhans cell J:142353
cecum inflammation J:142353
decreased body weight J:142353
heart inflammation J:142353
increased anal adenocarcinoma incidence J:142353
increased colon adenocarcinoma incidence J:142353
increased gastric adenocarcinoma incidence J:142353
increased inflammatory response J:142353
increased large intestine adenocarcinoma incidence J:142353
increased rectum adenocarcinoma incidence J:142353
increased stomach tumor incidence J:142353
increased tumor incidence J:142353
large intestinal inflammation J:142353
lung inflammation J:142353
premature death J:142353
proctitis J:142353
small intestinal inflammation J:142353
stomach inflammation J:142353
Tgfb1tm1Rif/Tgfb1tm1Rif
Not Specified 		abnormal immune system physiology J:141786
Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		decreased Langerhans cell number J:126147
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD 		increased regulatory T cell number J:196160
increased T-helper 1 cell number J:196160
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory