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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725
86 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd4tm1Knw/Cd4tm1Knw
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1 		premature death J:99033
Cd8atm1Mak/Cd8atm1Mak
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * C57BL/6 * CF-1 		premature death J:99033
Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1+
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2 		abnormal cutaneous collagen fibril morphology J:68448
normal immune system phenotype J:68448
overexpanded pulmonary alveolus J:68448
Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2 		prenatal lethality J:68448
Foxn1nu/Foxn1nu
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * BALB/c * CF-1 		abnormal T cell physiology J:99033
decreased inflammatory response J:99033
premature death J:99033
Foxp3tm1Flv/Foxp3+
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		increased regulatory T cell number J:123547
Ifngtm1Ts/Ifngtm1Ts
Tgfb1tm1Doe/Tgfb1tm1Doe
C.129-Ifngtm1Ts Tgfb1tm1Doe 		cachexia J:69346
decreased body weight J:69346
increased circulating alanine transaminase level J:69346
liver inflammation J:69346
normal liver/biliary system phenotype J:69346
premature death J:69346
Ighmtm1Cgn/Ighm+
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * C57BL/6 * CF-1 		increased cell proliferation J:99033
thymus hypoplasia J:99033
Ighmtm1Cgn/Ighmtm1Cgn
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * C57BL/6 * CF-1 		abnormal inflammatory response J:99033
cachexia J:99033
premature death J:99033
thymus hypoplasia J:99033
Il4tm2Nnt/Il4tm2Nnt
Tgfb1tm1Doe/Tgfb1tm1Doe
C.Cg-Tgfb1tm1Doe Il4tm2Nnt 		increased circulating alanine transaminase level J:69346
liver inflammation J:69346
postnatal lethality, complete penetrance J:69346
Prkdcscid/Prkdcscid
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129 * C3H * CF-1 		abnormal intromission J:129629
abnormal spermatid morphology J:129629
abnormal spermatogenesis J:129629
decreased body size J:129629
decreased body weight J:129629
decreased circulating follicle stimulating hormone level J:129629
decreased circulating luteinizing hormone level J:129629
decreased circulating testosterone level J:129629
decreased mounting behavior J:129629
decreased retroperitoneal fat pad weight J:129629
decreased spleen weight J:129629
decreased testes secretion J:129629
failure of copulatory plug deposition J:129629
failure of ejaculation J:129629
increased lung weight J:129629
male infertility J:129629
oligozoospermia J:129629
normal reproductive system phenotype J:129629
small seminiferous tubules J:129629
Tgfb1tm1.1Mki/Tgfb1tm1.1Mki
C57BL/6-Tgfb1tm1.1Mki 		decreased circulating aldosterone level J:194237
hypovolemia J:194237
increased circulating angiotensinogen level J:194237
increased circulating renin level J:194237
Tgfb1tm1Jmu/Tgfb1+
involves: 129S6/SvEvTac * C57BL/6 		prenatal lethality, incomplete penetrance J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu
involves: 129 * C57BL/6J * ICR * Swiss Webster 		intracranial hemorrhage J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
involves: 129S6/SvEvTac * C57BL/6 		abnormal immune system physiology J:120085
abnormal visceral yolk sac morphology J:120085
absent Langerhans cell J:120085
absent vitelline blood vessels J:120085
decreased body size J:120085
excessive folding of visceral yolk sac J:120085
heart inflammation J:120085
liver inflammation J:120085
lung inflammation J:120085
pale yolk sac J:120085
pancreas inflammation J:120085
postnatal lethality J:120085
prenatal lethality, incomplete penetrance J:120085
stomach inflammation J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster 		abnormal extraembryonic tissue morphology J:120085
abnormal immune system physiology J:120085
abnormal liver morphology J:120085
abnormal lung morphology J:120085
absent Langerhans cell J:120085
postnatal lethality, incomplete penetrance J:120085
prenatal lethality, incomplete penetrance J:120085
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129 * BALB/c * C57BL/6J * Swiss Webster 		intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129 * C57BL/6J * ICR * Swiss Webster 		abnormal brain vasculature morphology J:136106
hydrocephaly J:136106
intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster 		absent vitelline blood vessels J:136106
embryonic lethality during organogenesis, incomplete penetrance J:136106
intracranial hemorrhage J:136106
postnatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129 * BALB/c * C57BL/6J * Swiss Webster 		intracranial hemorrhage J:136106
prenatal lethality, incomplete penetrance J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129 * C57BL/6J * ICR * Swiss Webster 		abnormal brain vasculature morphology J:136106
cleft secondary palate J:136106
enlarged brain ventricles J:136106
hydrocephaly J:136106
intracranial hemorrhage J:136106
normal mortality/aging J:136106
neonatal lethality, complete penetrance J:136106
normal respiratory system phenotype J:136106
Tgfb1tm1Jmu/Tgfb1tm1Jmu
Tgfb3tm1Doe/Tgfb3tm1Doe
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster 		absent vitelline blood vessels J:136106
embryonic lethality during organogenesis, incomplete penetrance J:136106
intracranial hemorrhage J:136106
prenatal lethality, incomplete penetrance J:136106
Tgfb1tm1Mki/Tgfb1tm1Mki
C57BL/6-Tgfb1tm1Mki 		abnormal fluid regulation J:194237
abnormal homeostasis J:194237
abnormal urine potassium level J:194237
decreased circulating angiotensinogen level J:194237
decreased circulating potassium level J:194237
decreased circulating renin level J:194237
decreased heart rate J:194237
decreased urine chloride ion level J:194237
decreased urine osmolality J:194237
decreased urine sodium level J:194237
enlarged adrenal glands J:194237
hyperactivity J:194237
hypervolemia J:194237
increased basal metabolism J:194237
increased body temperature J:194237
increased circulating aldosterone level J:194237
increased circulating corticosterone level J:194237
increased fluid intake J:194237
increased systemic arterial systolic blood pressure J:194237
oliguria J:194237
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL 		increased regulatory T cell number J:196160
increased susceptibility to autoimmune diabetes J:196160
increased T-helper 1 cell number J:196160
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory