Tgfb3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tgfb3
transforming growth factor, beta 3
MGI:98727

38 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tgfb3^tm1(cre)Vk/Tgfb3^tm1(cre)Vk involves: 129S1/Sv * 129X1/SvJ	cleft palate	J:128938
Tgfb3^{tm1.1(KOMP)Vlcg}/Tgfb3⁺ C57BL/6N-Tgfb3^{tm1.1(KOMP)Vlcg}/Tcp	abnormal testis morphology	J:211773
	enlarged lymph nodes	J:211773
Tgfb3^{tm1.1(KOMP)Vlcg}/Tgfb3^{tm1.1(KOMP)Vlcg} C57BL/6N-Tgfb3^{tm1.1(KOMP)Vlcg}/Tcp	preweaning lethality, complete penetrance	J:211773
Tgfb3^tm1Doe/Tgfb3⁺ involves: 129P2/OlaHsd	abnormal small intestinal villus morphology	J:76342
Tgfb3^tm1Doe/Tgfb3⁺ involves: 129P2/OlaHsd	decreased enterocyte apoptosis	J:76342
Tgfb3^tm1Doe/Tgfb3^tm1Doe either: (involves: 129 * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)	abnormal respiratory conducting tube morphology	J:29901
	absent gastric milk in neonates	J:29901
	anterior cleft palate	J:29901
	cleft palate	J:29901
	complete cleft palate	J:29901
	cyanosis	J:29901
	dehydration	J:29901
	neonatal lethality, complete penetrance	J:29901
	persistence of medial edge epithelium during palatal shelf fusion	J:29901
	respiratory distress	J:29901
Tgfb3^tm1Doe/Tgfb3^tm1Doe involves: 129 * C57BL/6J * ICR * Swiss Webster	cleft palate	J:136106
	normal respiratory system phenotype	J:136106
Tgfb3^tm1Doe/Tgfb3^tm1Doe involves: 129P2/OlaHsd * C57BL/6	decreased neuron apoptosis	J:117465
Tgfb3^tm1Doe/Tgfb3^tm1Doe involves: 129P2/OlaHsd * C57BL/6	loss of dopaminergic neurons	J:117465
Tgfb3^tm1Doe/Tgfb3^tm1Doe involves: 129P2/OlaHsd * C57BL/6J	abnormal periderm development	J:315539
	abnormal secondary palate development	J:315539
	cleft palate	J:315539
	persistence of medial edge epithelium during palatal shelf fusion	J:315539
Tgfb3^tm1Jhg/Tgfb3^tm1Jhg either: (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal lung development	J:29902, J:111447
	abnormal lung saccule morphology	J:111447
	abnormal lung vasculature morphology	J:29902, J:111447
	abnormal pulmonary alveolus morphology	J:29902
	abnormal pulmonary elastic fiber morphology	J:111447
	abnormal pulmonary interalveolar septum morphology	J:29902
	abnormal pulmonary vein morphology	J:29902
	abnormal suckling behavior	J:29902
	absent gastric milk in neonates	J:29902
	atelectasis	J:29902
	cleft secondary palate	J:29902
	cyanosis	J:29902
	decreased type II pneumocyte number	J:29902, J:111447
	dilated respiratory conducting tube	J:29902
	hemothorax	J:29902
	impaired lung alveolus development	J:29902
	lung hemorrhage	J:29902
	neonatal lethality, complete penetrance	J:29902
	persistence of medial edge epithelium during palatal shelf fusion	J:29902
	pulmonary hypoplasia	J:29902
	respiratory distress	J:29902
	thick lung-associated mesenchyme	J:29902, J:111447
Tgfb3^tm1Moaz/Tgfb3^tm1.1Moaz Tg(EIIa-cre)C5379Lmgd/0 involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N	abnormal suckling behavior	J:181226
	absent gastric milk in neonates	J:181226
	cleft palate	J:181226
	complete cleft palate	J:181226
	neonatal lethality, complete penetrance	J:181226
	respiratory distress	J:181226
Tgfb3^tm1Moaz/Tgfb3^tm1Moaz involves: 129S6/SvEvTac * Black Swiss * C57BL/6J	no abnormal phenotype detected	J:181226

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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