Tgfbr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tgfbr1
transforming growth factor, beta receptor I
MGI:98728

79 phenotypes from 11 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd207^{tm2.1(cre)Bjec}/Cd207⁺ Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl involves: 129S4/SvJaeSor * C57BL/6	abnormal type IV hypersensitivity reaction	J:179630
	decreased dendritic cell number	J:179630
Gt(ROSA)26Sor^{tm1(Tgfbr1)Crm}/Gt(ROSA)26Sor⁺ Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0 involves: 129S7/SvEvBrd C57BL/6 * DBA/2	abnormal artery morphology	J:134135
	abnormal blood vessel morphology	J:134135
	abnormal blood vessel physiology	J:134135
	abnormal dermal layer morphology	J:134135
	abnormal kidney arterial blood vessel morphology	J:134135
	abnormal lung vasculature morphology	J:134135
	abnormal skin condition	J:134135
	decreased body weight	J:134135
	decreased subcutaneous adipose tissue amount	J:134135
	renal interstitial fibrosis	J:134135
	sparse hair	J:134135
	thick dermal layer	J:134135
	thick skin	J:134135
	thin epidermis	J:134135
	vascular smooth muscle hypertrophy	J:134135
Hprt1^{tm1(CAG-Tgfbr1)Lba}/Hprt1^{tm1(CAG-Tgfbr1)Lba} Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2	abnormal T cell activation	J:148747
Hprt1^{tm1(CAG-Tgfbr1)Lba}/Y Tg(Cd4-cre)1Cwi/0 involves: 129 C57BL/6 * DBA/2	abnormal T cell activation	J:148747
Tg(Col2a1-cre/ERT2)1Dic/0 Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl involves: 129 * C57BL/6	abnormal articular cartilage morphology	J:271724
	abnormal synovial joint morphology	J:271724
	increased chondrocyte apoptosis	J:271724
	osteoarthritis	J:271724
	osteophytes	J:271724
Tgfbr1^R244Q/Tgfbr1⁺ either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)	abnormal cartilage development	J:175236
	enhanced wound healing	J:175236
Tgfbr1^R244Q/Tgfbr1^R244Q either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)	abnormal cartilage development	J:175236
	enhanced wound healing	J:175236
Tgfbr1^tm1.1Hcd/Tgfbr1⁺ 129S6(Cg)-Tgfbr1^tm1.1Hcd	abnormal aorta bulb morphology	J:204960
	abnormal aorta elastic fiber morphology	J:204960
	abnormal aortic arch morphology	J:204960
	abnormal coronary artery morphology	J:204960
	aortic dissection	J:204960
	ascending aorta aneurysm	J:204960
	dilated aorta bulb	J:204960
	hemopericardium	J:204960
	hemothorax	J:204960
	increased aorta wall thickness	J:204960
	kyphosis	J:204960
	premature coronal suture closure	J:204960
	premature cranial suture closure	J:204960
	premature death	J:204960
	premature lambdoid suture closure	J:204960
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S/Sv C57BL/6 * FVB/N	normal cardiovascular system phenotype	J:164749
	decreased cardiac muscle contractility	J:164749
	dilated cardiomyopathy	J:164749
	premature death	J:164749
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(Acvrl1-cre)L1Spo/0 involves: 129 * FVB	normal cardiovascular system phenotype	J:130020
	no abnormal phenotype detected	J:130020
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(Mx1-cre)1Cgn/0 involves: 129 * C57BL/6 * CBA	normal hematopoietic system phenotype	J:86262
	increased hematopoietic stem cell proliferation	J:86262
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(Nes-cre)1Atp/0 involves: 129 * FVB/N	abnormal medial nasal prominence morphology	J:138715
	abnormal palatal shelf morphology	J:138715
	bilateral cleft upper lip	J:138715
	cleft upper lip	J:138715
	lethality throughout fetal growth and development, complete penetrance	J:138715
	maxillary prominence hypoplasia	J:138715
	palatal shelf hypoplasia	J:138715
	unilateral cleft upper lip	J:138715
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(Tie1-cre)9Ref/0 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ)	abnormal vitelline vasculature morphology	J:98373
	prenatal lethality, complete penetrance	J:98373
Tgfbr1^tm1.1Vlcg/Tgfbr1^tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Tgfbr1^tm1Bopa/Tgfbr1^tm1Bopa B6.129S1-Tgfbr1^tm1Bopa	embryonic lethality, complete penetrance	J:143706
Tgfbr1^tm1Dgen/Tgfbr1^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	preweaning lethality, complete penetrance	J:101679
Tgfbr1^tm1Karl/Tgfbr1^tm1.1Karl Tg(GATA5-cre)1Krc/0 involves: 129	abnormal bronchiole epithelium morphology	J:157922
	abnormal lung development	J:157922
	abnormal pulmonary alveolus morphology	J:157922
	abnormal skin development	J:157922
	decreased club cell number	J:157922
	dilated respiratory conducting tube	J:157922
	neonatal lethality, complete penetrance	J:157922
	small lung	J:157922
Tgfbr1^tm1Karl/Tgfbr1^tm1Karl Not Specified	abnormal angiogenesis	J:68770
	abnormal neural tube morphology	J:68770
	abnormal placenta labyrinth morphology	J:68770
	abnormal visceral yolk sac morphology	J:68770
	absent vitelline blood vessels	J:68770
	decreased embryo size	J:68770
	embryonic growth retardation	J:68770
	embryonic lethality during organogenesis, complete penetrance	J:68770
	kinked neural tube	J:68770
	pericardial effusion	J:68770
Tgfbr1^tm1Mulm/Tgfbr1^tm1Mulm involves: 129P2/OlaHsd	absent vitelline blood vessels	J:128498
Tgfbr1^tm1Mulm/Tgfbr1^tm1Mulm involves: 129P2/OlaHsd	embryonic lethality during organogenesis, complete penetrance	J:128498
Tgfbr1^tm1Spo/Tgfbr1^tm1Spo either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)	abnormal vascular smooth muscle morphology	J:104918
	abnormal vitelline vascular remodeling	J:104918
	embryonic growth retardation	J:104918
	embryonic lethality during organogenesis, complete penetrance	J:104918
	excessive folding of visceral yolk sac	J:104918

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