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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfbr2
transforming growth factor, beta receptor II
MGI:98729
168 phenotypes from 12 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd4tm1(cre/ERT2)Thbu/Cd4+
Tgfbr2tm1Karl/Tgfbr2tm1Karl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:204579
normal immune system phenotype J:204579
increased memory T cell number J:204579
increased regulatory T cell number J:204579
Cd19tm1(cre)Cgn/Cd19+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * BALB/c 		abnormal B cell physiology J:90558
abnormal B-1 B cell morphology J:90558
abnormal B-1 B cell number J:90558
absent plasma cells J:90558
decreased IgA level J:90558
enlarged Peyer's patches J:90558
increased IgG level J:90558
increased IgM level J:90558
increased leukocyte cell number J:90558
Dcttm1(cre)Bee/Dcttm1(cre)Bee
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Tg(Dct-lacZ)A12Jkn/0
involves: 129/Sv * C57BL/6 * C57BL/6J * CBA 		abnormal coat/hair pigmentation J:157070
abnormal hair follicle melanocyte morphology J:157070
ectopic hair follicle melanin granules J:157070
ectopic melanocytes J:157070
pigment incontinence J:157070
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal pancreas development J:116129
Tg(CAG-cre/Esr1*)5Amc/0
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal electroretinogram waveform feature J:221181
abnormal pericyte morphology J:221181
abnormal retina blood vessel morphology J:221181
abnormal retina layer morphology J:221181
abnormal retina morphology J:221181
abnormal retina neuronal layer morphology J:221181
abnormal retina vasculature morphology J:221181
decreased a-wave amplitude J:221181
decreased b-wave amplitude J:221181
decreased retina ganglion cell number J:221181
hypoxia J:221181
increased retina apoptosis J:221181
microgliosis J:221181
persistence of hyaloid vascular system J:221181
retina detachment J:221181
retina hemorrhage J:221181
retina microaneurysm J:221181
retina neovascularization J:221181
thin retina outer nuclear layer J:221181
vitreous body hemorrhage J:221181
Tg(CD2-Tgfbr2)1Grs/0
C57BL/6-Tg(CD2-Tgfbr2)1Grs/Nci 		enlarged lymph nodes J:97523
enlarged spleen J:97523
increased T cell proliferation J:97523
Tg(CD2-Tgfbr2)1Grs/?
C57BL/6-Tg(CD2-Tgfbr2)1Grs/Nci 		abnormal CD8-positive, alpha beta T cell morphology J:93665
cachexia J:93665
increased leukemia incidence J:93665
increased T cell derived lymphoma incidence J:93665
increased T cell proliferation J:93665
lethargy J:93665
respiratory distress J:93665
Tgfbr2em1(IMPC)Rbrc/Tgfbr2+
C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc 		abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
enlarged heart J:211773
enlarged kidney J:211773
small liver J:211773
Tgfbr2em1(IMPC)Rbrc/Tgfbr2em1(IMPC)Rbrc
C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc 		preweaning lethality, complete penetrance J:211773
Tgfbr2tm1.1Hcd/Tgfbr2+
129S6(Cg)-Tgfbr2tm1.1Hcd 		abnormal aorta bulb morphology J:204960
abnormal aorta elastic fiber morphology J:204960
abnormal aortic arch morphology J:204960
abnormal coronary artery morphology J:204960
aortic dissection J:204960
ascending aorta aneurysm J:204960
dilated aorta bulb J:204960
hemopericardium J:204960
hemothorax J:204960
increased aorta wall thickness J:204960
kyphosis J:204960
premature death J:204960
Tgfbr2tm1.1Hlm/Tgfbr2tm1.1Hlm
involves: 129S6/SvEvTac * C57BL/6 		preweaning lethality, complete penetrance J:75073
Tgfbr2tm1.1Karl/Tgfbr2tm1.1Karl
involves: 129/Sv * C57BL/6 		abnormal erythropoiesis J:77844
absent vitelline blood vessels J:77844
decreased embryo size J:77844
enlarged pericardium J:77844
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S6/SvEvTac * C57BL/6 		normal neoplasm J:177379
no abnormal phenotype detected J:75073
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:164749
decreased cardiac muscle contractility J:164749
dilated cardiomyopathy J:164749
premature death J:164749
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal aortic arch morphology J:104325
abnormal brain dura mater morphology J:86042
abnormal cranium morphology J:86042
abnormal dorsal aorta morphology J:104325
abnormal fourth pharyngeal arch artery morphology J:104325
abnormal mandible morphology J:86042
abnormal neurocranium morphology J:86042
abnormal palatal mesenchymal cell proliferation J:86042
abnormal palate morphology J:86042
abnormal parietal bone morphology J:86042
abnormal soft palate muscle morphology J:208431
absent frontal bone J:86042
absent mandibular angle J:86042
cleft secondary palate J:86042
decreased cranial neural crest cell proliferation J:86042
interrupted aortic arch, type b J:104325
palatal shelf hypoplasia J:86042
palatal shelves fail to meet at midline J:86042
persistent truncus arteriosus J:104325
postnatal lethality, complete penetrance J:104325
retroesophageal right subclavian artery J:104325
small cranium J:86042
small mandible J:86042
small mandibular condyloid process J:86042
small mandibular coronoid process J:86042
small maxilla J:86042
ventricular septal defect J:104325
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Acvrl1-cre)L1Spo/0
involves: 129S6/SvEvTac * FVB/N 		normal cardiovascular system phenotype J:130020
no abnormal phenotype detected J:130020
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD 		increased inflammatory response J:196160
premature death J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal T cell activation J:148747
autoimmune response J:148747
liver inflammation J:148747
postnatal lethality, complete penetrance J:148747
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(CD207-cre)1Dhka/?
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		decreased Langerhans cell number J:126147
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		increased prostate gland adenocarcinoma incidence J:204736
increased prostate intraepithelial neoplasia incidence J:204736
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(KRT14-cre)52Smr/0
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		abnormal hard palate morphology J:112634
abnormal nasal septum morphology J:112634
abnormal palatal shelf fusion at midline J:112634
abnormal palatal shelf morphology J:112634
abnormal palate development J:112634
abnormal primary palate development J:112634
abnormal skeletal muscle fiber morphology J:208431
abnormal soft palate morphology J:208431
abnormal soft palate muscle morphology J:208431
absent gastric milk in neonates J:112634
centrally nucleated skeletal muscle fibers J:208431
cleft secondary palate J:112634
cleft soft palate J:208431
neonatal lethality J:112634
small levator veli palatini muscle J:208431
small tensor veli palatini muscle J:208431
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Twist2tm1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 		abnormal branching involved in lung morphogenesis J:143910
abnormal bronchial cartilage morphology J:143910
abnormal bronchus morphology J:143910
abnormal lung lobe morphology J:143910
abnormal tracheal cartilage morphology J:143910
decreased tracheal cartilage ring number J:143910
dilated respiratory conducting tube J:143910
lethality throughout fetal growth and development, complete penetrance J:143910
Tgfbr2tm1Dgen/Tgfbr2+
involves: 129P2/OlaHsd 		abnormal fat pad morphology J:148831
increased fatty acids level J:148831
increased total body fat amount J:148831
Tgfbr2tm1Hlm/Tgfbr2tm1Hlm
involves: 129S6/SvEvTac * C57BL/6 		preweaning lethality, complete penetrance J:75073
Tgfbr2tm1Karl/Tgfbr2tm1Karl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:77844
Tgfbr2tm1Karl/Tgfbr2tm1Karl
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal aortic arch and aortic arch branch attachment J:96359
abnormal blood vessel physiology J:96359
abnormal cartilage morphology J:96359
abnormal craniofacial bone morphology J:96359
abnormal hindbrain morphology J:96359
abnormal midbrain morphology J:96359
abnormal neural crest cell morphology J:96359
abnormal parathyroid gland morphology J:96359
abnormal vasodilation J:96359
absent parathyroid glands J:96359
blood vessel congestion J:96359
cleft secondary palate J:96359
congestive heart failure J:96359
palatal shelves fail to meet at midline J:96359
parathyroid hypoplasia J:96359
perinatal lethality J:96359
persistent truncus arteriosus J:96359
small thymus J:96359
ventricular septal defect J:96359
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(AMELX-cre)A1Kul/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NCr 		abnormal enamel mineralization J:205404
abnormal enamel morphology J:205404
abnormal molar morphology J:205404
abnormal tooth attrition J:205404
reduced enamel thickness J:205404
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal stationary movement J:77844
eye inflammation J:77844
increased inflammatory response J:77844
liver inflammation J:77844
pancreas inflammation J:77844
paralysis J:77844
premature death J:77844
small thymus J:77844
stomach inflammation J:77844
weight loss J:77844
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal vitelline vasculature morphology J:98373
prenatal lethality, complete penetrance J:98373
Tgfbr2tm1Mmt/Tgfbr2tm1Mmt
involves: 129S2/SvPas * C57BL/6J 		abnormal embryonic hematopoiesis J:73414
abnormal vitelline vasculature morphology J:73414
embryonic growth retardation J:73414
embryonic lethality during organogenesis, complete penetrance J:73414
pale yolk sac J:73414
Tgfbr2tm1Sjkm/Tgfbr2+
Not Specified 		increased hepatocyte proliferation J:71591
increased incidence of tumors by chemical induction J:71591
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory