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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgfbr2
transforming growth factor, beta receptor II
MGI:98729
55 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 		normal immune system phenotype J:148747
Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 		normal immune system phenotype J:148747
Ifngtm1Ts/Ifngtm1Ts
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL 		normal immune system phenotype J:196160
normal mortality/aging J:196160
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 		increased metastatic potential J:116129
increased pancreas tumor incidence J:116129
increased pancreatic ductal adenocarcinoma incidence J:116129
increased pancreatic intraepithelial neoplasia incidence J:116129
premature death J:116129
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm 		abnormal myeloid leukocyte morphology J:177379
increased B cell number J:177379
increased lung adenocarcinoma incidence J:177379
increased metastatic potential J:177379
increased T cell number J:177379
premature death J:177379
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal duodenum morphology J:116129
abnormal hepatic portal vein morphology J:116129
abnormal hepatic portal vein thrombosis J:116129
dilated gallbladder J:116129
distended abdomen J:116129
enlarged spleen J:116129
hemorrhagic ascites J:116129
hepatic necrosis J:116129
increased metastatic potential J:116129
increased pancreas tumor incidence J:116129
increased pancreatic ductal adenocarcinoma incidence J:116129
increased pancreatic intraepithelial neoplasia incidence J:116129
jaundice J:116129
paralysis J:116129
premature death J:116129
weight loss J:116129
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Tg(Acta2-cre/ERT2)#Pcn/0
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(H2-K-Fosl2,-EGFP)13Wag/0
B6.Cg-Tgfbr2tm1Karl Tg(Acta2-cre/ERT2)#Pcn Tg(H2-K-Fosl2,-EGFP)13Wag 		normal cardiovascular system phenotype J:238723
lung inflammation J:238723
pulmonary fibrosis J:238723
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL 		abnormal abdominal lymph node morphology J:196160
abnormal immune serum protein physiology J:196160
abnormal immune system morphology J:196160
abnormal immune system organ morphology J:196160
abnormal immune system physiology J:196160
abnormal interleukin secretion J:196160
abnormal spleen morphology J:196160
decreased interleukin-9 secretion J:196160
decreased interleukin-17 secretion J:196160
decreased regulatory T cell number J:196160
normal immune system phenotype J:196160
increased interferon-gamma secretion J:196160
increased interleukin-2 secretion J:196160
increased interleukin-21 secretion J:196160
increased regulatory T cell number J:196160
increased susceptibility to autoimmune diabetes J:196160
normal mortality/aging J:196160
pancreas inflammation J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Foxp3-EGFP/cre)1cJbs/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL 		normal immune system phenotype J:196160
increased regulatory T cell number J:196160
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * NOD * SJL 		normal immune system phenotype J:196160
increased susceptibility to autoimmune diabetes J:196160
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tagln-cre)1Her/?
Gt(ROSA)26Sortm1Sor/?
involves: 129 * C57BL/6 * SJL 		abnormal heart morphology J:128498
abnormal vitelline vasculature morphology J:128498
delayed brain development J:128498
delayed heart development J:128498
embryonic growth retardation J:128498
lethality throughout fetal growth and development, complete penetrance J:128498
pale yolk sac J:128498
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/?
Gt(ROSA)26Sortm1Sor/?
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal pharyngeal arch morphology J:128498
abnormal vitelline vasculature morphology J:128498
absent vitelline blood vessels J:128498
embryonic growth retardation J:128498
embryonic lethality during organogenesis, complete penetrance J:128498
pericardial effusion J:128498
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory