Th Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Th
tyrosine hydroxylase
MGI:98735

64 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cox4i2^tm1Hutt/Cox4i2^tm1.1Jlob Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * C57BL/6	abnormal physiological response to hypoxia	J:302384
Dbh^tm2(Th)Rpa/Dbh⁺ Th^tm1Rpa/Th^tm1Rpa involves: 129S7/SvEvBrd	abnormal nervous system physiology	J:30404
	adipsia	J:30404
	aphagia	J:30404
	decreased body size	J:30404
	decreased body weight	J:30404
	decreased brain size	J:30404
	decreased dopamine level	J:30404
	decreased locomotor activity	J:30404
	decreased stereotypic behavior	J:30404
	hunched posture	J:30404
	poor grooming	J:30404
	premature death	J:30404
	weight loss	J:30404
Dbh^tm2(Th)Rpa/Dbh⁺ Th^tm1Rpa/Th^tm1Rpa involves: 129S7/SvEvBrd * C57BL/6J	abnormal gait	J:58125
	akinesia	J:58125
	catalepsy	J:58125
	decreased compensatory feeding amount	J:58125
	decreased food intake	J:58125
	decreased locomotor activity	J:58125
	hunched posture	J:58125
	hyperactivity	J:58125
	hyporesponsive to tactile stimuli	J:58125
	impaired behavioral response to addictive substance	J:58125
	impaired coordination	J:58125
	increased stereotypic behavior	J:58125
	premature death	J:58125
Dbh^tm2(Th)Rpa/Dbh⁺ Th^tm5Rpa/Th^tm5Rpa involves: 129S4/SvJaeSor	abnormal avoidance learning behavior	J:154773
	decreased dopamine level	J:154773
Dbh^tm2(Th)Rpa/Dbh⁺ Th^tm5Rpa/Th^tm5Rpa involves: 129S4/SvJaeSor * C57BL/6	abnormal eating behavior	J:110806
	abnormal motor capabilities/coordination/movement	J:110806
	abnormal postnatal growth	J:110806
	decreased body weight	J:110806
	decreased compensatory feeding amount	J:110806
	decreased dopamine level	J:110806
	hyperactivity	J:110806
	impaired coordination	J:110806
	increased food intake	J:110806
	increased thigmotaxis	J:110806
	normal mortality/aging	J:110806
Dbh^tm2(Th)Rpa/Dbh⁺ Th^tm5Rpa/Th^tm5Rpa involves: 129S4/SvJaeSor * C57BL/6	aphagia	J:110806
	bradykinesia	J:110806
	decreased body weight	J:110806
	decreased dopamine level	J:110806
	decreased locomotor activity	J:110806
	premature death	J:110806
	weight loss	J:110806
Grpr^tm1Jfb/Grpr^tm1Jfb Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	excessive scratching	J:167752
Med22^{tm1a(EUCOMM)Hmgu}/Med22⁺ Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * C57BL/6N	normal renal/urinary system phenotype	J:300239
Med22^{tm1a(EUCOMM)Hmgu}/Med22^{tm1a(EUCOMM)Hmgu} Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * C57BL/6N	preweaning lethality, complete penetrance	J:300239
Ndufa4l2^tm1.1Jlob/Ndufa4l2^tm1.2Jlob Th^tm1(cre)Te/Th⁺ involves: 129S/Sv * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac	abnormal physiological response to hypoxia	J:302384
Or51e2^tm3.1Mom/Or51e2^tm3.1Mom Th^tm1(cre)Te/? involves: 129X1/SvJ * C57BL/6	abnormal type I cell of carotid body physiology	J:350385
Psmc1^tm1Maye/Psmc1^tm1.1Maye Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * CD-1	abnormal noradrenaline level	J:138991
	alpha-synuclein inclusion body	J:138991
	decreased body size	J:138991
	decreased dopamine level	J:138991
	gliosis	J:138991
	neuron degeneration	J:138991
	postnatal lethality	J:138991
Psmc1^tm1Maye/Psmc1^tm1Maye Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * CD-1	abnormal noradrenaline level	J:138991
	alpha-synuclein inclusion body	J:138991
	decreased body size	J:138991
	decreased dopamine level	J:138991
	gliosis	J:138991
	neuron degeneration	J:138991
	postnatal lethality, complete penetrance	J:138991
Sdhd^tm1Jlob/Sdhd^tm2Jlob Th^tm1(cre)Te/Th⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal adrenal chromaffin cell morphology	J:186713
	abnormal dopaminergic neuron morphology	J:186713
	bradykinesia	J:186713
	decreased birth body size	J:186713
	decreased dopamine level	J:186713
	decreased locomotor activity	J:186713
	decreased neuron number	J:186713
	loss of dopaminergic neurons	J:186713
	normal neoplasm	J:186713
	oxidative stress	J:186713
	premature death	J:186713
Slc17a6^tm1Kldr/Slc17a6^tm1Kldr Th^tm1(cre)Te/Th⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pain threshold	J:167752
	decreased chemically-elicited antinociception	J:167752
	excessive scratching	J:167752
	normal homeostasis/metabolism phenotype	J:167752
	increased pruritus	J:167752
	increased thermal nociceptive threshold	J:167752
	mixed cellular infiltration to dermis	J:167752
	skin lesions	J:167752
	thick epidermis	J:167752
Tg(CAG-AlkF1174L,-luc)60Jhsc/0 Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ C57BL/6 * FVB/N	adrenal gland hyperplasia	J:186696
	increased metastatic potential	J:186696
	increased neuroblastoma incidence	J:186696
Th^tm1Srt/Th^tm1Srt Tyr^c/Tyr^c involves: 129S2/SvPas * C57BL/6J * ICR	abnormal adrenaline level	J:54692
	abnormal noradrenaline level	J:54692
	decreased dopamine level	J:54692
	prenatal lethality, complete penetrance	J:54692
Th^tm2Te/Th^tm2Te involves: 129X1/SvJ * C57BL/6	bradykinesia	J:93552
	decreased body size	J:93552
	decreased dopamine level	J:93552
	decreased noradrenaline level	J:93552
	increased serotonin level	J:93552

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24