Thbs1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Thbs1
thrombospondin 1
MGI:98737

32 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Thbs1^tm1Hyn/Thbs1^tm1Hyn involves: C57BL/6J	abnormal intestine morphology	J:79641
	anemia	J:79641
	increased carcinoma incidence	J:79641
	increased intestinal adenoma incidence	J:79641
	increased tumor incidence	J:79641
	lordosis	J:79641
	premature death	J:79641
	weight loss	J:79641
Thbs1^tm1Hyn/Thbs1^tm1Hyn Thbs2^tm1Bst/Thbs2^tm1Bst involves: 129T2/SvEms * 129X1/SvJ	abnormal skin condition	J:78876
	abnormal tail morphology	J:78876
	delayed wound healing	J:78876
	impaired macrophage chemotaxis	J:78876
	increased bleeding time	J:78876
	lordosis	J:78876
	lung inflammation	J:78876
	prenatal lethality, incomplete penetrance	J:78876
Thbs1^tm1Hyn/Thbs1^tm1Hyn Trp53^tm1Tyj/Trp53⁺ involves: 129S2/SvPas * C57BL/6	abnormal tumor morphology	J:72391
	gastric polyps	J:72391
	increased adenocarcinoma incidence	J:72391
	increased adenoma incidence	J:72391
	increased carcinoma incidence	J:72391
	increased fibrosarcoma incidence	J:72391
	increased histiocytic sarcoma incidence	J:72391
	increased liver adenocarcinoma incidence	J:72391
	increased lung adenocarcinoma incidence	J:72391
	increased lymphoma incidence	J:72391
	increased mammary adenocarcinoma incidence	J:72391
	increased osteosarcoma incidence	J:72391
	increased pancreas tumor incidence	J:72391
	increased papilloma incidence	J:72391
	increased sarcoma incidence	J:72391
	increased squamous cell carcinoma incidence	J:72391
	premature death	J:72391
Thbs1^tm1Hyn/Thbs1^tm1Hyn Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas * C57BL/6	increased adenocarcinoma incidence	J:72391
	increased carcinoma incidence	J:72391
	increased fibrosarcoma incidence	J:72391
	increased hemangiosarcoma incidence	J:72391
	increased histiocytic sarcoma incidence	J:72391
	increased lymphoma incidence	J:72391
	increased pancreas tumor incidence	J:72391
	increased sarcoma incidence	J:72391
	increased small intestine adenocarcinoma incidence	J:72391
	premature death	J:72391

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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