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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Thra
thyroid hormone receptor alpha
MGI:98742
132 phenotypes from 17 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(CAG-cre/Esr1*)5Amc/?
Thratm1Ffla/Thra+
involves: 129/Sv * C57BL/6 * CBA 		abnormal cerebellum morphology J:125353
abnormal heart rate J:125353
abnormal postnatal growth J:125353
delayed bone ossification J:125353
Tg(Nes-cre)1Kln/0
Thraem6Ffla/Thra+
involves: 129 * C57BL/6 * SJL 		abnormal cerebellum morphology J:268664
postnatal lethality, incomplete penetrance J:268664
Tg(Nes-cre)1Kln/0
Thratm1Ffla/Thra+
involves: 129 * C57BL/6 * SJL 		abnormal cerebellum morphology J:268664
postnatal lethality, incomplete penetrance J:268664
Thraem1Ffla/Thra+
C57BL/6-Thraem1Ffla 		abnormal enterocyte proliferation J:268664
decreased hemoglobin content J:268664
decreased trabecular bone thickness J:268664
delayed endochondral bone ossification J:268664
normal homeostasis/metabolism phenotype J:268664
increased triiodothyronine level J:268664
short femur J:268664
normal skeleton phenotype J:268664
Thraem2Ffla/Thra+
C57BL/6-Thraem2Ffla 		abnormal enterocyte proliferation J:268664
decreased hemoglobin content J:268664
decreased trabecular bone thickness J:268664
delayed endochondral bone ossification J:268664
increased triiodothyronine level J:268664
short femur J:268664
normal skeleton phenotype J:268664
Thraem3Ffla/Thra+
C57BL/6-Thraem3Ffla 		delayed endochondral bone ossification J:268664
normal homeostasis/metabolism phenotype J:268664
normal skeleton phenotype J:268664
Thraem4Ffla/Thra+
C57BL/6-Thraem4Ffla 		delayed endochondral bone ossification J:268664
normal homeostasis/metabolism phenotype J:268664
normal skeleton phenotype J:268664
Thraem5Ffla/Thra+
C57BL/6-Thraem5Ffla 		decreased trabecular bone thickness J:268664
normal homeostasis/metabolism phenotype J:268664
normal skeleton phenotype J:268664
Thratm1.1Fcas/Thratm1.1Fcas
B6.Cg-Thratm1.1Fcas 		abnormal glucose homeostasis J:179839
abnormal insulin secretion J:179839
abnormal mitochondrial ATP synthesis coupled electron transport J:179839
abnormal pancreatic islet morphology J:179839
decreased body temperature J:179839
decreased food intake J:179839
impaired glucose tolerance J:179839
increased circulating glucagon level J:179839
increased circulating glucose level J:179839
increased circulating insulin level J:179839
increased circulating thyroxine level J:179839
increased circulating triiodothyronine level J:179839
increased glucagon secretion J:179839
increased insulin secretion J:179839
increased insulin sensitivity J:179839
insulin resistance J:179839
small pancreatic islets J:179839
Thratm1b(EUCOMM)Wtsi/Thra+
C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics 		abnormal contextual conditioning behavior J:211773
abnormal heart left ventricle morphology J:211773
abnormal retina inner nuclear layer morphology J:211773
decreased body length J:211773
decreased exploration in new environment J:211773
decreased grip strength J:211773
decreased startle reflex J:211773
decreased total body fat amount J:211773
decreased total retina thickness J:211773
hyperactivity J:211773
improved glucose tolerance J:211773
increased blood urea nitrogen level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating creatinine level J:211773
increased hematocrit J:211773
increased vertical activity J:211773
limb grasping J:211773
short tibia J:211773
Thratm1b(EUCOMM)Wtsi/Thra+
C57BL/6N-Thratm1b(EUCOMM)Wtsi/J 		abnormal bone structure J:211773
hyperactivity J:211773
increased bone mineral content J:211773
increased bone mineral density J:211773
increased startle reflex J:211773
Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, incomplete penetrance J:211773
Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
C57BL/6N-Thratm1b(EUCOMM)Wtsi/J 		preweaning lethality, incomplete penetrance J:211773
Thratm1Brnt/Thra+
involves: 129S4/SvJae * C57BL/6 		abnormal defecation J:85803
abnormal enzyme/coenzyme activity J:85803
decreased core body temperature J:85803
decreased food intake J:85803
decreased heart rate J:85803
delayed hair appearance J:85803
impaired adaptive thermogenesis J:85803
impaired lipolysis J:85803
increased body weight J:85803
increased circulating glucose level J:85803
increased circulating insulin level J:85803
increased circulating leptin level J:85803
increased circulating thyroid-stimulating hormone level J:85803
increased circulating thyroxine level J:85803
increased circulating triiodothyronine level J:85803
increased epididymal fat pad weight J:85803
increased total body fat amount J:85803
insulin resistance J:85803
oliguria J:85803
reduced fertility J:85803
Thratm1Brnt/Thratm1Brnt
involves: 129S4/SvJae * C57BL/6 		prenatal lethality, complete penetrance J:85803
Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2 		abnormal cerebellum external granule cell layer morphology J:125353
abnormal Purkinje cell dendrite morphology J:125353
ataxia J:125353
decreased spleen weight J:125353
delayed endochondral bone ossification J:125353
delayed eyelid opening J:125353
disproportionate dwarf J:125353
female infertility J:125353
impaired adaptive thermogenesis J:125353
increased heart rate J:125353
irregular heartbeat J:125353
postnatal growth retardation J:125353
postnatal lethality, incomplete penetrance J:125353
Thratm1Jas/Thratm1Jas
involves: 129S1/Sv * 129X1/SvJ 		abnormal enterocyte morphology J:84537
abnormal enterocyte physiology J:84537
abnormal enterocyte proliferation J:84537
abnormal enzyme/coenzyme activity J:84537
abnormal intestinal goblet cell morphology J:84537
abnormal intestinal mucosa morphology J:84537
abnormal long bone epiphyseal plate morphology J:52829
abnormal small intestine morphology J:52829
abnormal thyroid follicle morphology J:52829
decreased circulating thyroxine level J:68577
decreased heart rate J:68577
decreased heart ventricle muscle contractility J:68577
decreased small intestinal villus height J:84537
decreased small intestine length J:52829
prolonged QRS complex duration J:68577
thyroid gland hypoplasia J:52829
Thratm1Ven/Thratm1Ven
involves: 129P2/OlaHsd * BALB/c 		abnormal cochlear outer hair cell morphology J:111711
normal behavior/neurological phenotype J:103702
decreased activity of thyroid gland J:45675
decreased body temperature J:45675
decreased heart rate J:45675
normal hearing/vestibular/ear phenotype J:48666, J:118178
prolonged QT interval J:45675
Thratm1Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl 		abnormal postnatal growth J:100290
decreased body weight J:100290
Thratm2Jas/Thratm2Jas
involves: 129 		abnormal bone structure J:120899
abnormal chondrocyte physiology J:114970
abnormal enterocyte physiology J:84537
abnormal enterocyte proliferation J:84537
abnormal enzyme/coenzyme activity J:84537
abnormal intestinal goblet cell morphology J:84537
abnormal intestinal mucosa morphology J:84537
abnormal long bone epiphyseal plate morphology J:120899
abnormal osteoclast physiology J:120899
abnormal response/metabolism to endogenous compounds J:120899
abnormal trabecular bone morphology J:120899
decreased activity of thyroid gland J:120899
decreased body weight J:120899
decreased circulating insulin-like growth factor I level J:120899
decreased circulating thyroxine level J:68577, J:120899
decreased compact bone thickness J:120899
decreased heart rate J:68577
decreased heart ventricle muscle contractility J:68577
decreased osteoclast cell number J:120899
decreased small intestinal villus height J:84537
decreased width of hypertrophic chondrocyte zone J:120899
delayed endochondral bone ossification J:120899
increased bone mass J:120899
increased long bone epiphyseal plate size J:120899
increased trabecular bone thickness J:120899
osteosclerosis J:120899
postnatal growth retardation J:120899
prolonged QRS complex duration J:68577
short limbs J:120899
short tail J:120899
short tibia J:120899
normal skeleton phenotype J:120899
Thratm2Jas/Thratm2Jas
involves: 129/Sv * C57BL/6 		decreased circulating thyroxine level J:126521
Thratm2Ven/Thra+
involves: 129P2/OlaHsd * BALB/c 		abnormal compact bone morphology J:72959
abnormal thyroid gland physiology J:72959
abnormal thyroid-stimulating hormone level J:72959
abnormal trabecular bone morphology J:72959
decreased activity of thyroid gland J:72959
decreased body weight J:72959
decreased bone mineral density J:72959
decreased circulating insulin-like growth factor I level J:72959
decreased circulating thyroxine level J:72959
decreased circulating triiodothyronine level J:72959
decreased compact bone area J:72959
increased activity of thyroid gland J:72959
increased body temperature J:72959
increased heart rate J:72959
increased total body fat amount J:72959
obese J:72959
postnatal growth retardation J:72959
Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c 		abnormal compact bone morphology J:72959
abnormal osteoclast physiology J:72959
abnormal pup retrieval J:72959
abnormal thyroid follicle morphology J:72959
abnormal thyroid gland physiology J:72959
abnormal thyroid-stimulating hormone level J:72959
abnormal trabecular bone morphology J:72959
decreased activity of thyroid gland J:72959
decreased areal bone mineral density J:72959
decreased body weight J:72959
decreased bone mineral content J:72959
decreased circulating insulin-like growth factor I level J:72959
decreased circulating thyroxine level J:72959
decreased circulating triiodothyronine level J:72959
decreased compact bone area J:72959
increased activity of thyroid gland J:72959
increased body temperature J:72959
increased heart rate J:72959
increased total body fat amount J:72959
obese J:72959
perinatal lethality, incomplete penetrance J:72959
postnatal growth retardation J:72959
prolonged estrous cycle J:72959
reduced female fertility J:72959
Thratm2Ven/Thratm2Ven
involves: 129P2/OlaHsd * BALB/c * C57BL/6J 		normal hearing/vestibular/ear phenotype J:118402
Thratm2Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl 		decreased body weight J:100290
Thratm3Jas/Thratm3Jas
involves: 129 		abnormal enterocyte physiology J:84537
abnormal enterocyte proliferation J:84537
abnormal enzyme/coenzyme activity J:84537
abnormal intestinal goblet cell morphology J:84537
Thratm3Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6NCrl 		abnormal cerebellum external granule cell layer morphology J:100910
abnormal hippocampus morphology J:100910
abnormal locomotor coordination J:100910
abnormal object recognition memory J:100910
abnormal postnatal growth J:100290
decreased body weight J:100290
increased anxiety-related response J:100910
Thratm3Ven/Thratm3Ven
involves: 129P2/OlaHsd * C57BL/6NCrl 		decreased body weight J:100290
postnatal lethality, complete penetrance J:100290
Thratm4.1Ven/Thra+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N 		increased circulating triiodothyronine level J:166513
Thratm4.1Ven/Thratm4.1Ven
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N 		decreased liver weight J:166513
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory