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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Thra
thyroid hormone receptor alpha
MGI:98742
90 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ncoa1tm1Bwo/Ncoa1tm1Bwo
Thratm2Jas/Thratm2Jas
B6.129-Thratm2Jas Ncoa1tm1Bwo 		abnormal response/metabolism to endogenous compounds J:126521
decreased circulating thyroid-stimulating hormone level J:126521
increased circulating thyroid-stimulating hormone level J:126521
increased circulating thyroxine level J:126521
increased circulating triiodothyronine level J:126521
Thratm1Jas/Thra+
Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ 		postnatal growth retardation J:52829
Thratm1Jas/Thratm1Jas
Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ 		abnormal long bone epiphyseal plate morphology J:52829
abnormal small intestine morphology J:52829
abnormal thyroid follicle morphology J:52829
decreased body weight J:52829
decreased small intestinal villus size J:52829
delayed intestine development J:52829
delayed skeletal maturation J:52829
increased circulating thyroid-stimulating hormone level J:52829
increased circulating thyroxine level J:52829
increased triiodothyronine level J:52829
postnatal growth retardation J:52829
premature death J:52829
thyroid gland hyperplasia J:52829
Thratm1Syc/Thra+
involves: 129S6/SvEvTac 		decreased body weight J:95397
decreased cardiac muscle cell glucose uptake J:95397
decreased mean systemic arterial blood pressure J:95397
small heart J:95397
Thratm1Syc/Thra+
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss 		abnormal bone mineral content J:217018
abnormal bone mineralization J:103351, J:217018
abnormal bone remodeling J:217018
abnormal bone strength J:217018
abnormal bone structure J:103351
abnormal compact bone morphology J:103351
abnormal hormone level J:217018
abnormal joint morphology J:217018
abnormal long bone diaphysis morphology J:217018
abnormal long bone epiphyseal ossification zone morphology J:103351
abnormal long bone epiphyseal plate morphology J:103351
abnormal long bone epiphyseal plate proliferative zone J:103351
abnormal long bone metaphysis morphology J:217018
abnormal osteoclast physiology J:217018
abnormal trabecular bone morphology J:103351
decreased bone mineral content J:217018
decreased bone resorption J:217018
decreased length of long bones J:217018
decreased osteoclast cell number J:217018
decreased width of hypertrophic chondrocyte zone J:103351
delayed cranial suture closure J:103351
delayed endochondral bone ossification J:103351, J:217018
delayed intramembranous bone ossification J:103351
increased bone mineral content J:217018
increased bone trabecula number J:217018
increased compact bone thickness J:217018
increased compact bone volume J:217018
increased diameter of long bones J:217018
increased long bone epiphyseal plate size J:217018
increased thyroid-stimulating hormone level J:217018
increased trabecular bone thickness J:217018
increased trabecular bone volume J:217018
increased triiodothyronine level J:217018
large fontanelles J:103351
postnatal growth retardation J:103351
short tibia J:103351
short ulna J:103351
wide cranial sutures J:103351
Thratm1Syc/Thra+
involves: 129S6/SvEvTac * NIH Black Swiss 		decreased activity of thyroid gland J:73446
decreased body length J:73446
decreased body weight J:73446
decreased litter size J:73446
increased circulating thyroid-stimulating hormone level J:73446
increased circulating triiodothyronine level J:73446
premature death J:73446
reduced female fertility J:73446
reduced fertility J:73446
reduced male fertility J:73446
Thratm1Ven/Thra+
Thrbtm1Df/Thrbtm1Df
B6.129-Thratm1Ven Thrbtm1Df 		increased or absent threshold for auditory brainstem response J:73382
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrb+
B6.129-Thratm1Ven Thrbtm1Df 		normal hearing/vestibular/ear phenotype J:73382
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
B6.129-Thratm1Ven Thrbtm1Df 		abnormal auditory brainstem response J:73382
abnormal pituitary hormone level J:117324
abnormal sperm motility J:117324
decreased body weight J:117324
decreased follicle stimulating hormone level J:117324
decreased growth hormone level J:117324
decreased luteinizing hormone level J:117324
decreased prolactin level J:117324
decreased testis weight J:117324
female infertility J:73382
increased thyroid-stimulating hormone level J:117324
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		increased circulating thyroid-stimulating hormone level J:95391
increased circulating thyroxine level J:95391
increased circulating triiodothyronine level J:95391
normal neoplasm J:95391
small pituitary gland J:95391
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J 		abnormal cochlear inner hair cell physiology J:73382
abnormal cochlear outer hair cell physiology J:73382
abnormal organ of Corti morphology J:73382
abnormal pillar cell morphology J:73382
abnormal tectorial membrane morphology J:73382
abnormal tectorial membrane striated-sheet matrix morphology J:73382
decreased body size J:73382
decreased cochlear outer hair cell electromotility J:73382
decreased endocochlear potential J:73382
delayed inner ear development J:73382
enlarged tectorial membrane J:73382
female infertility J:73382
increased susceptibility to xenobiotic induced morbidity/mortality J:73382
Thratm2Ven/Thra+
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J 		normal hearing/vestibular/ear phenotype J:118402
postnatal growth retardation J:118402
Thratm2Ven/Thratm2Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J 		abnormal thyroid follicle morphology J:118402
abnormal thyroid hormone level J:118402
decreased circulating thyroxine level J:118402
decreased circulating triiodothyronine level J:118402
normal hearing/vestibular/ear phenotype J:118402
postnatal growth retardation J:118402
Thratm3Ven/Thra+
Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl 		abnormal postnatal growth J:100290
decreased body weight J:100290
Thratm3Ven/Thra+
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl 		decreased body weight J:100290
Thratm3Ven/Thratm3Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl 		preweaning lethality, complete penetrance J:100290
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11/12/2024
MGI 6.24 		The Jackson Laboratory