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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Timp1
tissue inhibitor of metalloproteinase 1
MGI:98752
34 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Timp1tm1b(EUCOMM)Hmgu/Y
C57BL/6N-Timp1tm1b(EUCOMM)Hmgu/H 		abnormal femur morphology J:211773
abnormal humerus morphology J:211773
Timp1tm1Pds/Y
involves: 129S4/SvJae 		abnormal response to cardiac infarction J:95572
aortic aneurysm J:101938, J:102182
normal growth/size/body region phenotype J:49303
increased circulating testosterone level J:49303
increased left ventricle diastolic pressure J:60524
increased testis weight J:49303
Timp1tm1Pds/Y
involves: 129S4/SvJae * C57BL/6 		abnormal systemic arterial blood pressure J:211441
normal cardiovascular system phenotype J:211441
Timp1tm1Pds/Timp1tm1Pds
involves: 129S4/SvJae 		abnormal endometrial gland development J:96729
abnormal estrus J:64154
abnormal response to cardiac infarction J:95572
abnormal uterus development J:96729
absent estrous cycle J:64154
absent estrus J:64154
aortic aneurysm J:101938, J:102182
decreased bone marrow cell number J:100411
decreased circulating progesterone level J:64154
decreased litter size J:73618
decreased susceptibility to bacterial infection J:94836
normal growth/size/body region phenotype J:40265
normal hematopoietic system phenotype J:100411
increased circulating estradiol level J:64154
increased left ventricle diastolic pressure J:60524
increased uterus weight J:64154, J:96729
normal neoplasm J:43744
prolonged proestrus J:64154
reduced female fertility J:73618
normal reproductive system phenotype J:40265
short estrus J:64154
Timp1tm1Pds/Timp1tm1Pds
involves: 129S4/SvJae * C57BL/6 		increased neutrophil cell number J:112941
increased susceptibility to induced morbidity/mortality J:112941
increased vascular permeability J:112941
lung hemorrhage J:112941
lung inflammation J:112941
normal respiratory system phenotype J:112941
weight loss J:112941
Timp1tm1Pds/Timp1tm1Pds
involves: C57BL/6 		decreased susceptibility to bacterial infection J:94836
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory