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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Timp3
tissue inhibitor of metalloproteinase 3
MGI:98754
73 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Timp3tm1.1(KOMP)Vlcg/Timp3tm1.1(KOMP)Vlcg
C57BL/6N-Timp3tm1.1(KOMP)Vlcg/J 		abnormal retina blood vessel morphology J:211773
abnormal retina morphology J:211773
increased mean corpuscular volume J:211773
Timp3tm1Hest/Timp3tm1Hest
either: B6.129S1-Timp3tm1Hest or (involves: 129S1/Sv * CD-1) 		abnormal choroid vasculature morphology J:136890
abnormal vascular branching morphogenesis J:136890
Timp3tm1Osya/Timp3tm1Osya
B6.129P2-Timp3tm1Osya 		abdominal aorta aneurysm J:193744
abnormal abdominal aorta morphology J:193744
abnormal aorta morphology J:193744
abnormal aorta wall morphology J:193744
abnormal blood vessel physiology J:193744
abnormal kidney morphology J:154849
aortitis J:193744
normal cardiovascular system phenotype J:154849
enlarged kidney J:154849
hydronephrosis J:154849
increased susceptibility to injury J:154849
premature death J:193744
Timp3tm1Osya/Timp3tm1Osya
involves: 129P2/OlaHsd * C57BL/6 		abnormal artery morphology J:211441
abnormal blood vessel elastic tissue morphology J:211441
abnormal blood vessel physiology J:211441
abnormal learning/memory/conditioning J:154709
abnormal spatial learning J:154709
abnormal systemic arterial blood pressure J:211441
normal behavior/neurological phenotype J:154709
normal cardiovascular system phenotype J:211441
decreased systemic arterial blood pressure J:211441
decreased vasodilation J:211441
Timp3tm1Osya/Timp3tm1Osya
involves: 129P2/OlaHsd * C57BL/6J 		decreased susceptibility to induced hypothermia J:215209
increased body temperature J:215209
increased carbon dioxide production J:215209
increased oxygen consumption J:215209
Timp3tm1Rkho/Timp3tm1Rkho
B6.129-Timp3tm1Rkho 		abnormal branching involved in terminal bronchiole morphogenesis J:85546
abnormal cardiac muscle relaxation J:102205
abnormal heart morphology J:102205
abnormal liver lobule morphology J:92948
cardiac hypertrophy J:102205
decreased body weight J:102205
decreased heart ventricle muscle contractility J:102205
decreased left ventricle developed pressure J:102205
decreased left ventricle systolic pressure J:102205
decreased pulmonary alveolus wall thickness J:161579
dilated cardiomyopathy J:102205
dilated heart left ventricle J:102205
dilated terminal bronchiole tube J:85546
hepatic necrosis J:92948
impaired liver regeneration J:92948
impaired lung alveolus development J:85546, J:161579
increased hepatocyte apoptosis J:92948
increased susceptibility to induced morbidity/mortality J:92948
increased tumor necrosis factor secretion J:92948
liver inflammation J:92948
normal mortality/aging J:92948, J:102205
overexpanded pulmonary alveolus J:161579
normal respiratory system phenotype J:92948, J:102205
Timp3tm1Rkho/Timp3tm1Rkho
FVB.129-Timp3tm1Rkho 		abnormal apoptosis J:71690
abnormal involution of the mammary gland J:71690
abnormal lactation J:71690
normal respiratory system phenotype J:71690
Timp3tm1Rkho/Timp3tm1Rkho
involves: 129 * C57BL/6 		abnormal bronchiole morphology J:71609
abnormal heart left ventricle morphology J:112033
abnormal pulmonary alveolus morphology J:71609
abnormal respiratory system physiology J:71609
cardiac fibrosis J:112033
cardiac hypertrophy J:112033
normal cellular phenotype J:71609
congestive heart failure J:112033
decreased cardiac muscle contractility J:112033
dilated cardiomyopathy J:112033
dilated heart left ventricle J:112033
normal endocrine/exocrine gland phenotype J:71609
hunched posture J:71609
increased response of heart to induced stress J:112033
increased susceptibility to induced morbidity/mortality J:112033
lethargy J:71609
overexpanded pulmonary alveolus J:71609
premature death J:71609
pulmonary edema J:112033
normal renal/urinary system phenotype J:71609
respiratory distress J:71609
ruffled hair J:71609
Timp3tm1Web/Timp3+
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 		abnormal Bruch membrane morphology J:78059
abnormal retina pigment epithelium morphology J:78059
Timp3tm1Web/Timp3tm1Web
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 		abnormal Bruch membrane morphology J:78059
abnormal retina pigment epithelium morphology J:78059
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory