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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmod1
tropomodulin 1
MGI:98775
51 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
FVB/N-Tg(Myh6-Tmod1)65Msus 		abnormal myocardial fiber morphology J:58879
anasarca J:58879
dilated cardiomyopathy J:58879
dilated heart left ventricle J:58879
increased heart weight J:58879
lethality at weaning, incomplete penetrance J:58879
postnatal lethality, incomplete penetrance J:58879
premature death J:58879
Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
involves: FVB/N 		abnormal atrial thrombosis J:107823
abnormal cardiac muscle relaxation J:107823
abnormal cardiovascular system physiology J:107823
abnormal heart morphology J:107823
abnormal heart ventricle morphology J:107823
abnormal myocardial fiber morphology J:107823
congestive heart failure J:107823
decreased cardiac muscle contractility J:107823
decreased cardiac output J:107823
decreased heart left ventricle muscle contractility J:107823
decreased heart rate J:107823
dilated cardiomyopathy J:107823
dilated heart left ventricle J:107823
exophthalmos J:107823
increased heart weight J:107823
increased susceptibility to induced morbidity/mortality J:107823
myocardial fiber degeneration J:107823
premature death J:107823
normal respiratory system phenotype J:107823
thin interventricular septum J:107823
thin myocardium J:107823
Tmod1tm1a(KOMP)Wtsi/Tmod1+
C57BL/6N-Tmod1tm1a(KOMP)Wtsi/Wtsi 		increased body weight J:175295
increased circulating alkaline phosphatase level J:175295
Tmod1tm1Sung/Tmod1tm1Sung
involves: 129S1/Sv * 129X1/SvJ 		abnormal embryonic erythrocyte morphology J:89956
abnormal embryonic tissue morphology J:89956
abnormal erythrocyte morphology J:89956
abnormal heart looping J:89956
abnormal heart tube morphology J:89956
abnormal myocardial fiber morphology J:89956
abnormal myocardial trabeculae morphology J:89956
abnormal vascular development J:89956
abnormal vitelline vasculature morphology J:89956
anemia J:89956
embryonic growth retardation J:89956
embryonic lethality during organogenesis, complete penetrance J:89956
irregular heartbeat J:89956
pericardial effusion J:89956
Tmod1tm1Vmf/Tmod1tm1Vmf
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal cardiac muscle contractility J:87158
abnormal cardiac output J:87158
abnormal fetal atrioventricular canal morphology J:87158
abnormal head development J:87158
abnormal heart development J:87158
abnormal myocardial fiber morphology J:87158
abnormal sarcomere morphology J:87158
absent heartbeat J:87158
absent myocardial trabeculae J:87158
decreased embryo size J:87158
distended pericardium J:87158
embryonic growth arrest J:87158
embryonic growth retardation J:87158
embryonic lethality during organogenesis, complete penetrance J:87158
excessive folding of visceral yolk sac J:87158
thin myocardium J:87158
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory