Top2a Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Top2a
topoisomerase (DNA) II alpha
MGI:98790

14 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Top2a^em2(IMPC)Tcp/Top2a⁺ C57BL/6NCrl-Top2a^em2(IMPC)Tcp/Tcp	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	abnormal skin morphology	J:211773
	enlarged urinary bladder	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased mean corpuscular volume	J:211773
	microphthalmia	J:211773
	small spleen	J:211773
	small thymus	J:211773
Top2a^em2(IMPC)Tcp/Top2a^em2(IMPC)Tcp C57BL/6NCrl-Top2a^em2(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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