Top2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Top2b
topoisomerase (DNA) II beta
MGI:98791

47 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Dkk3-cre)D9Tfur/0 Top2b^tm2Jcw/Top2b^tm2Jcw involves: 129S6/SvEvTac * C3H * C57BL/6	abnormal photoreceptor outer segment morphology	J:282250
	abnormal retina cone cell morphology	J:282250
	abnormal retina cone cell outer segment morphology	J:282250
	abnormal retina outer limiting membrane morphology	J:282250
	abnormal retina outer plexiform layer morphology	J:282250
	abnormal retina pigment epithelium morphology	J:282250
	abnormal retina rod cell morphology	J:282250
	abnormal retina rod cell outer segment morphology	J:282250
	photoreceptor outer segment degeneration	J:282250
	retina cone cell degeneration	J:282250
	retina photoreceptor degeneration	J:282250
	thin retina outer nuclear layer	J:282250
Top2b^em1(IMPC)Mbp/Top2b⁺ C57BL/6NCrl-Top2b^em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	abnormal spleen morphology	J:211773
	persistence of hyaloid vascular system	J:211773
	small spleen	J:211773
Top2b^em1(IMPC)Mbp/Top2b^em1(IMPC)Mbp C57BL/6NCrl-Top2b^em1(IMPC)Mbp/MbpMmucd	abnormal craniofacial morphology	J:211773
	abnormal head shape	J:211773
	abnormal placenta morphology	J:211773
	cleft palate	J:211773
	edema	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Top2b^tm1Jcw/Top2b^tm1Jcw involves: 129S1/Sv * 129X1/SvJ	abnormal innervation pattern to muscle	J:75958
	abnormal motor neuron innervation pattern	J:75958
	decreased embryo size	J:75958
	kyphosis	J:75958
	neonatal lethality, complete penetrance	J:75958
	paralysis	J:75958
	respiratory failure	J:75958
Top2b^tm2.1Jcw/Top2b^tm2.1Jcw involves: 129S4/SvJae * 129S6/SvEvTac	abnormal embryonic/fetal subventricular zone morphology	J:94879
	abnormal spine curvature	J:94879
	abnormal stratification in cerebral cortex	J:94879
	abnormal telencephalon development	J:94879
	absent subplate	J:94879
	decreased body size	J:94879
	decreased brain size	J:94879
	disorganized cortical plate	J:94879
	impaired neuronal migration	J:94879
	neonatal lethality, complete penetrance	J:94879
	respiratory failure	J:94879
	small olfactory bulb	J:94879
Top2b^tm2Jcw/Top2b^tm2.1Jcw Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ	abnormal cerebral cortex morphology	J:94879
	abnormal hippocampus granule cell layer	J:94879
	abnormal hippocampus morphology	J:94879
	abnormal hippocampus pyramidal cell layer	J:94879
	abnormal motor capabilities/coordination/movement	J:94879
	atelectasis	J:94879
	neonatal lethality, complete penetrance	J:94879
	respiratory failure	J:94879
	small olfactory bulb	J:94879
Top2b^tm2Jcw/Top2b^tm2Jcw 129S6/SvEvTac-Top2b^tm2Jcw	no abnormal phenotype detected	J:94879

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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