Tph1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tph1
tryptophan hydroxylase 1
MGI:98796

22 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tph1^tm1Bdr/Tph1^tm1Bdr Not Specified	normal behavior/neurological phenotype	J:81435
Tph1^tm1Bdr/Tph1^tm1Bdr Not Specified	normal skeleton phenotype	J:172746
Tph1^{tm1c(KOMP)Wtsi}/Tph1^{tm1c(KOMP)Wtsi} Tg(Ins2-cre)23Herr/0 involves: 129S4/SvJae * C57BL/6J * CBA/J	decreased pancreatic beta cell mass	J:284574
	decreased pancreatic beta cell proliferation	J:284574
	decreased physiological sensitivity to xenobiotic	J:284574
	impaired glucose tolerance	J:284574
Tph1^tm1Kry/Tph1^tm1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB	normal homeostasis/metabolism phenotype	J:146078
Tph1^tm1Kry/Tph1^tm1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB	normal skeleton phenotype	J:146078
Tph1^tm1Kry/Tph1^tm1Kry Tg(Vil1-cre)20Syr/0 involves: C57BL/6 * DBA/2	decreased serotonin level	J:146078
	increased bone mass	J:146078
	increased bone ossification	J:146078
	increased osteoblast cell number	J:146078
	increased osteoblast proliferation	J:146078
Tph1^tm1Mlt/Tph1^tm1Mlt either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal heart left ventricle pressure	J:99733
	decreased cardiac muscle contractility	J:99733
	decreased cardiac output	J:99733
	decreased cardiac stroke volume	J:99733
	decreased serotonin level	J:99733
	enlarged heart	J:99733
	fatigue	J:99733
	increased heart rate	J:99733
	pallor	J:99733
	respiratory distress	J:99733
Tph1^tm2Lex/Tph1^tm2Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal serotonin level	J:144582
Tph1^tm2Lex/Tph1^tm2Lex involves: 129S5/SvEvBrd * C57BL/6J	normal behavior/neurological phenotype	J:144582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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