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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tpm1
tropomyosin 1, alpha
MGI:98809
51 phenotypes from 7 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Myh6-Tpm1*D175N)#Dfw/0
Not Specified 		abnormal atrial thrombosis J:57365
abnormal heart ventricle pressure J:57365
abnormal interventricular septum morphology J:57365
abnormal myocardial fiber physiology J:57365
abnormal response to exercise J:57365
cardiac fibrosis J:57365
decreased cardiac muscle contractility J:57365
decreased cardiac muscle relaxation J:57365
disorganized myocardium J:57365
increased myocardial fiber size J:57365
myocardium hypertrophy J:57365
Tg(Myh6-Tpm1*E54K)30Dfw/0
involves: FVB/N 		abnormal myocardial fiber morphology J:137813
abnormal myocardial fiber physiology J:137813
congestive heart failure J:137813
decreased cardiac muscle contractility J:137813
decreased cardiac muscle relaxation J:137813
decreased cardiac output J:137813
decreased heart left ventricle muscle contractility J:137813
decreased left ventricle diastolic pressure J:137813
decreased left ventricle systolic pressure J:137813
decreased physiological sensitivity to xenobiotic J:137813
dilated cardiomyopathy J:137813
dilated heart ventricle J:137813
increased heart weight J:137813
increased myocardial fiber size J:137813
premature death J:137813
Tg(Myh6-Tpm1*E54K)67Dfw/0
involves: FVB/N 		abnormal bronchiole morphology J:137813
abnormal myocardial fiber morphology J:137813
abnormal myocardial fiber physiology J:137813
cardiac interstitial fibrosis J:137813
congestive heart failure J:137813
decreased cardiac muscle contractility J:137813
decreased cardiac muscle relaxation J:137813
decreased cardiac output J:137813
decreased heart left ventricle muscle contractility J:137813
decreased left ventricle diastolic pressure J:137813
decreased left ventricle systolic pressure J:137813
decreased physiological sensitivity to xenobiotic J:137813
dilated cardiomyopathy J:137813
dilated heart ventricle J:137813
edema J:137813
increased body weight J:137813
increased heart weight J:137813
increased myocardial fiber size J:137813
premature death J:137813
Tg(Myh6-Tpm1*E180G)57Dfw/0
involves: FVB/N 		abnormal atrial thrombosis J:127507
abnormal calcium ion homeostasis J:171021
abnormal cardiac muscle contractility J:127507, J:172340
abnormal cardiac muscle relaxation J:127507, J:172340
abnormal diastolic filling velocity J:127507
abnormal heart left ventricle morphology J:127507
abnormal heart septum morphology J:127507
abnormal heart ventricle morphology J:172340
abnormal myocardial fiber morphology J:127507
abnormal myocardial fiber physiology J:127507
cardiac fibrosis J:127507, J:172340
cardiac hypertrophy J:127507, J:171021, J:172340
decreased cardiac muscle contractility J:171021
decreased heart rate J:171021
heart left ventricle hypertrophy J:127507
increased cardiac muscle contractility J:172340
increased heart atrium size J:127507, J:172340
increased left ventricle diastolic pressure J:127507, J:172340
increased lung weight J:171021
lethargy J:127507
premature death J:127507
Tpm1em1Clo/Tpm1+
Not Specified 		abnormal endocardial heart tube morphology J:320916
abnormal heart looping J:320916
absent heartbeat J:320916
embryonic lethality between implantation and placentation, complete penetrance J:320916
hydrops fetalis J:320916
pericardial effusion J:320916
Tpm1tm1Dfw/Tpm1+
involves: 129P2/OlaHsd * Black Swiss 		no abnormal phenotype detected J:45833
Tpm1tm1Dfw/Tpm1tm1Dfw
involves: 129P2/OlaHsd * Black Swiss 		embryonic lethality, complete penetrance J:45833
Tpm1tm1Jse/Tpm1tm1Jse
involves: 129X1/SvJ * Black Swiss 		decreased embryo size J:44952
embryonic lethality during organogenesis, complete penetrance J:44952
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory