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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tpm1
tropomyosin 1, alpha
MGI:98809
17 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc4a3tm1Ges/Slc4a3tm1Ges
Tg(Myh6-Tpm1*E180G)57Dfw/0
involves: 129X1/SvJ * FVB/N 		abnormal calcium ion homeostasis J:171021
abnormal cardiac muscle relaxation J:171021
abnormal heart rate J:171021
cardiac hypertrophy J:171021
congestive heart failure J:171021
decreased cardiac muscle contractility J:171021
decreased heart rate J:171021
decreased left ventricle systolic pressure J:171021
decreased locomotor activity J:171021
decreased mean systemic arterial blood pressure J:171021
edema J:171021
increased lung weight J:171021
premature death J:171021
respiratory distress J:171021
rough coat J:171021
Tln2em1Clo/Tln2+
Tpm1em1Clo/Tpm1+
involves: C57BL/6 * DBA/2 		atrial septal defect J:320916
embryonic lethality between implantation and placentation, incomplete penetrance J:320916
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory