Hsp90b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hsp90b1
heat shock protein 90, beta (Grp94), member 1
MGI:98817

34 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hsp90b1^tm1.2Alee/Hsp90b1^tm1.2Alee involves: 129/Sv * C57BL/6J * FVB/N	abnormal fetal cardiomyocyte morphology	J:160900
	decreased embryo size	J:160900
	disorganized embryonic tissue	J:160900
	embryonic lethality between implantation and placentation, complete penetrance	J:160900
Hsp90b1^tm1Yarg/Hsp90b1^tm1Yarg B6.129X1-Hsp90b1^tm1Yarg	abnormal cell differentiation	J:146397
	abnormal developmental patterning	J:146397
	abnormal embryonic-extraembryonic boundary morphology	J:146397
	abnormal endoderm development	J:146397
	abnormal extraembryonic endoderm formation	J:146397
	abnormal extraembryonic tissue morphology	J:146397
	abnormal germ layer development	J:146397
	abnormal left-right axis patterning	J:146397
	absent amnion	J:146397
	absent chorion	J:146397
	absent proamniotic cavity	J:146397
	decreased embryo size	J:146397
	embryonic growth arrest	J:146397
	embryonic lethality between implantation and somite formation, complete penetrance	J:146397
	failure of primitive streak formation	J:146397
Hsp90b1^tm1Zhli/Hsp90b1^tm1.1Zhli Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S/SvEv	abnormal cytokine secretion	J:118427
	abnormal inflammatory response	J:118427
	abnormal macrophage physiology	J:118427
	increased susceptibility to bacterial infection	J:118427
	premature death	J:118427
Hsp90b1^tm1Zhli/Hsp90b1^tm1.1Zhli Tg(Ddx4-cre)1Dcas/0 involves: 129S/SvEv * FVB	abnormal acrosome morphology	J:168319
	abnormal sperm head morphology	J:168319
	abnormal sperm midpiece morphology	J:168319
	asthenozoospermia	J:168319
	enlarged sperm head	J:168319
	globozoospermia	J:168319
	male infertility	J:168319
	normal reproductive system phenotype	J:168319
Hsp90b1^tm1Zhli/Hsp90b1^tm1Zhli Tg(Tyr-cre/ERT2)13Bos/0 B6.Cg-Tg(Tyr-cre/ERT2)13Bos Hsp90b1^tm1Zhli	abnormal hair follicle melanogenesis	J:265851
	diluted coat color	J:265851
	reduced hair shaft melanin granule number	J:265851

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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