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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tfrc
transferrin receptor
MGI:98822
75 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sortm1(Tfrc*)Nca
involves: 129S4/SvJae * FVB/N 		increased circulating iron level J:133221
increased heart iron level J:133221
increased liver iron level J:133221
Tfrcem1(IMPC)H/Tfrc+
C57BL/6N-Tfrcem1(IMPC)H/H 		abnormal gait J:211773
abnormal vocalization J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
increased erythrocyte cell number J:211773
increased large unstained cell number J:211773
increased red blood cell distribution width J:211773
Tfrcem1(IMPC)H/Tfrcem1(IMPC)H
C57BL/6N-Tfrcem1(IMPC)H/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
TfrcMvd001/Tfrc+
C3HeB/FeJ-TfrcMvd001 		decreased mean corpuscular hemoglobin J:186868
decreased mean corpuscular volume J:186868
increased erythrocyte cell number J:186868
TfrcRbc6/Tfrc+
involves: C57BL/6 		abnormal hematopoietic system morphology/development J:330452
decreased hematocrit J:330452
decreased hemoglobin content J:330452
decreased mean corpuscular hemoglobin J:330452
decreased mean corpuscular volume J:330452
increased erythrocyte cell number J:330452
increased red blood cell distribution width J:330452
microcytic anemia J:330452
Tfrctm1Nca/Tfrc+
either: (involves: 129S4/SvJae * 129S6/SvEvTac) or (involves: 129S4/SvJae * C57BL/6) 		abnormal erythropoiesis J:54107
abnormal intestinal mineral absorption J:54107
abnormal iron homeostasis J:54107
abnormal iron level J:54107
decreased liver iron level J:54107
decreased mean corpuscular hemoglobin J:54107
decreased mean corpuscular volume J:54107
decreased spleen iron level J:54107
normal hematopoietic system phenotype J:54107
increased erythrocyte cell number J:54107
microcytosis J:54107
Tfrctm1Nca/Tfrctm1Nca
either: (involves: 129S4/SvJae * 129S6/SvEvTac) or (involves: 129S4/SvJae * C57BL/6) 		abnormal embryonic erythrocyte morphology J:54107
abnormal embryonic erythropoiesis J:54107
anemia J:54107
decreased erythroid progenitor cell number J:54107
embryo tissue necrosis J:54107
embryonic growth retardation J:54107
embryonic lethality, complete penetrance J:54107
hydrops fetalis J:54107
hypoxia J:54107
increased apoptosis J:54107
kinked neural tube J:54107
pallor J:54107
pericardial effusion J:54107
Tfrctm2Nca/Tfrctm2Nca
involves: 129S4/SvJae * FVB/N 		decreased circulating iron level J:133221
hypochromic microcytic anemia J:133221
Tfrctm3.1Nca/Tfrctm3.1Nca
involves: 129S4/SvJae * CD-1 		no abnormal phenotype detected J:224823
Tfrctm3.1Nca/Tfrctm3.1Nca
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal gonial bone morphology J:316198
abnormal hyoid bone morphology J:316198
abnormal mandible morphology J:316198
abnormal mandibular angle morphology J:316198
abnormal Meckel's cartilage morphology J:316198
abnormal secondary palate development J:316198
abnormal suckling behavior J:316198
abnormal tongue morphology J:316198
abnormal tympanic ring morphology J:316198
complete cleft palate J:316198
failure of palatal shelf elevation J:316198
micrognathia J:316198
neonatal lethality, complete penetrance J:316198
oral cleft J:316198
respiratory distress J:316198
short mandible J:316198
small mandibular condyloid process J:316198
small mandibular coronoid process J:316198
small Meckel's cartilage J:316198
Tfrctm3.1Nca/Tfrctm3.1Nca
Tg(Vil1-cre)20Syr/0
involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2 		abnormal colon morphology J:224823
abnormal duodenum morphology J:224823
abnormal enterocyte morphology J:224823
abnormal enterocyte proliferation J:224823
abnormal intestine morphology J:224823
abnormal small intestine morphology J:224823
blunted small intestinal villi J:224823
decreased body size J:224823
decreased colon length J:224823
distended stomach J:224823
melena J:224823
postnatal lethality, complete penetrance J:224823
Tfrctm3.1Nca/Tfrctm3.1Nca
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2 		abnormal enterocyte proliferation J:224823
blunted small intestinal villi J:224823
diarrhea J:224823
distended stomach J:224823
premature death J:224823
weight loss J:224823
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory