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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ttn
titin
MGI:98864
92 phenotypes from 12 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ttnem1Kage/Ttnem1Kage
B6J.B6N-Ttnem1Kage 		abnormal heart morphology J:302920
abnormal myocardium layer morphology J:302920
normal cardiovascular system phenotype J:302920
decreased heart left ventricle muscle contractility J:302920
dilated heart left ventricle J:302920
normal muscle phenotype J:302920
Ttnmdm/Ttnmdm
involves: C57BL/6J 		decreased body weight J:87870
normal muscle phenotype J:87870
premature death J:87870
Ttnmdm/Ttnmdm
Not Specified 		kyphosis J:14016
muscle degeneration J:14016
myositis J:14016
premature death J:14016
Ttnshru/Ttnshru
B6.BTBR-Ttnshru 		abnormal angiogenesis J:92178
abnormal blood circulation J:92178
abnormal blood vessel morphology J:92178
abnormal cardiovascular development J:92178
abnormal cardiovascular system morphology J:74786
abnormal dorsal aorta morphology J:92178
abnormal first pharyngeal arch morphology J:92178
abnormal frontonasal mesenchyme morphology J:92178
abnormal heart development J:92178
abnormal somite development J:92178
abnormal vitelline vascular remodeling J:92178
absent organized vascular network J:92178
cellular necrosis J:92178
decreased cardiac muscle contractility J:92178
decreased embryo size J:92178
embryonic lethality during organogenesis, complete penetrance J:92178
hemorrhage J:92178
hypoxia J:92178
increased apoptosis J:74786
microcephaly J:92178
pericardial edema J:92178
trabecula carnea hypoplasia J:92178
Ttntm1.1Her/Ttntm1.1Her
involves: 129S4/SvJae * 129T2/SvEms 		abnormal heart ventricle morphology J:111284
abnormal myocardial fiber morphology J:111284
abnormal myocardial trabeculae morphology J:111284
abnormal myocardium layer morphology J:111284
decreased embryo size J:111284
embryonic growth retardation J:111284
increased embryonic tissue cell apoptosis J:111284
pericardial effusion J:111284
prenatal lethality, complete penetrance J:111284
thin myocardium J:111284
Ttntm1.1Hgra/Ttntm1.1Hgra
B6.Cg-Ttntm1.1Hgra 		abnormal heart left atrium morphology J:206712
abnormal heart left ventricle morphology J:206712
abnormal myocardial fiber morphology J:206712
cardiac hypertrophy J:206712
impaired exercise endurance J:206712
increased heart left atrium weight J:206712
Ttntm1.1Hgra/Ttntm1.1Hgra
involves: 129S6/SvEvTac * C57BL/6J 		abnormal diaphragm morphology J:206713
abnormal muscle contractility J:206713
decreased soleus weight J:206713
kyphosis J:206713
skeletal muscle fiber atrophy J:206713
Ttntm1.1Isrd/Ttn+
involves: 129S2/SvPas * C57BL/6 		abnormal limb muscle morphology J:165576
abnormal quadriceps morphology J:165576
abnormal tibialis anterior morphology J:165576
dystrophic muscle J:165576
embryonic lethality during organogenesis, incomplete penetrance J:165576
prenatal lethality, incomplete penetrance J:165576
Ttntm1.1Isrd/Ttntm1.1Isrd
involves: 129S2/SvPas * C57BL/6 		abnormal gastrocnemius morphology J:165576
abnormal limb muscle morphology J:165576
abnormal M line morphology J:165576
abnormal skeletal muscle morphology J:165576
abnormal soleus morphology J:165576
abnormal tibialis anterior morphology J:165576
cardiac interstitial fibrosis J:165576
centrally nucleated skeletal muscle fibers J:165576
decreased heart ventricle muscle contractility J:165576
dilated cardiomyopathy J:165576
dilated heart left ventricle J:165576
dystrophic muscle J:165576
embryonic lethality during organogenesis, incomplete penetrance J:165576
impaired skeletal muscle contractility J:165576
increased left ventricle diastolic pressure J:165576
increased left ventricle systolic pressure J:165576
increased variability of skeletal muscle fiber size J:165576
myositis J:165576
prenatal lethality, incomplete penetrance J:165576
skeletal muscle fiber necrosis J:165576
Ttntm1Brge/Ttn+
B6.Cg-Ttntm1Brge 		abnormal heart left ventricle morphology J:152736
abnormal response/metabolism to endogenous compounds J:152736
cardiac interstitial fibrosis J:152736
normal cardiovascular system phenotype J:152736
decreased cardiac muscle contractility J:152736
dilated cardiomyopathy J:152736
dilated heart left ventricle J:152736
Ttntm1Brge/Ttntm1Brge
B6.Cg-Ttntm1Brge 		abnormal heart development J:152736
abnormal myocardium layer morphology J:152736
absent heartbeat J:152736
decreased embryo size J:152736
embryonic growth retardation J:152736
embryonic lethality, complete penetrance J:152736
pericardial edema J:152736
Ttntm1Her/Ttn+
Not Specified 		no abnormal phenotype detected J:81993
Ttntm1Her/Ttntm1Her
Not Specified 		no abnormal phenotype detected J:81993
Ttntm1Her/Ttntm1Her
Tg(Ckmm-cre)5Khn/0
Not Specified 		abnormal gait J:81993
abnormal M line morphology J:81993
abnormal posture J:81993
abnormal sarcomere morphology J:81993
blepharoptosis J:81993
normal cardiovascular system phenotype J:81993
decreased body size J:81993
postnatal growth retardation J:81993
premature death J:81993
progressive muscle weakness J:81993
Ttntm1Her/Ttntm1Her
Tg(Myh6-cre)2182Mds/0
Not Specified 		lethality throughout fetal growth and development, complete penetrance J:81993
Ttntm1Mgot/Ttntm1Mgot
involves: 129 * C57BL/6 		abnormal myocardial fiber physiology J:125922
abnormal sarcomere morphology J:125922
decreased diastolic filling velocity J:125922
decreased heart weight J:125922
ventricular hypoplasia J:125922
Ttntm2.1Hgra/Ttntm2.1Hgra
B6J.Cg-Ttntm2.1Hgra 		abnormal heart left ventricle morphology J:216466
abnormal myocardial fiber morphology J:216466
abnormal sarcomere morphology J:216466
heart left ventricle hypertrophy J:216466
impaired exercise endurance J:216466
increased heart left atrium weight J:216466
increased myocardial fiber size J:216466
thick ventricular wall J:216466
Ttntm2.1Mgot/Ttn+
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal muscle physiology J:169969
Ttntm2.1Mgot/Ttntm2.1Mgot
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal cardiac muscle contractility J:169969
abnormal muscle physiology J:169969
abnormal sarcomere morphology J:169969
cardiac hypertrophy J:169969
heart left ventricle hypertrophy J:169969
increased heart left ventricle size J:169969
increased heart left ventricle weight J:169969
increased myocardial fiber size J:169969
Ttntm3.1Mgot/Ttntm3.1Mgot
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		no abnormal phenotype detected J:172357
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory