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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tuba1a
tubulin, alpha 1A
MGI:98869
42 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tuba1aem1(IMPC)Bay/Tuba1aem1(IMPC)Bay
C57BL/6N-Tuba1aem1(IMPC)Bay/BayMmucd 		abnormal embryo size J:211773
abnormal facial morphology J:211773
edema J:211773
hemorrhage J:211773
preweaning lethality, incomplete penetrance J:211773
Tuba1aem1Rstot/Tuba1aem1Rstot
involves: C57BL/6J * C57BL/6N 		abnormal basal ganglion morphology J:278765
abnormal cortical intermediate zone morphology J:278765
abnormal cortical plate morphology J:278765
abnormal neuron physiology J:278765
abnormal spine curvature J:278765
abnormal telencephalon development J:278765
abnormal third ventricle morphology J:278765
cleft palate J:278765
edema J:278765
enlarged lateral ventricles J:278765
enlarged third ventricle J:278765
hemorrhage J:278765
increased cortical ventricular zone thickness J:278765
increased neuronal precursor proliferation J:278765
preweaning lethality, complete penetrance J:278765
Tuba1aem1Rstot/Tuba1aquas
involves: C57BL/6J * C57BL/6N 		abnormal basal ganglion morphology J:278765
abnormal cerebral cortex morphology J:278765
abnormal cortical intermediate zone morphology J:278765
abnormal spine curvature J:278765
cleft palate J:278765
enlarged lateral ventricles J:278765
enlarged third ventricle J:278765
preweaning lethality, complete penetrance J:278765
Tuba1aem2Rstot/Tuba1aem2Rstot
involves: C57BL/6J * C57BL/6N 		abnormal basal ganglion morphology J:278765
abnormal cortical intermediate zone morphology J:278765
abnormal cortical plate morphology J:278765
abnormal spine curvature J:278765
abnormal telencephalon development J:278765
abnormal third ventricle morphology J:278765
cleft palate J:278765
edema J:278765
enlarged lateral ventricles J:278765
enlarged third ventricle J:278765
hemorrhage J:278765
increased cortical ventricular zone thickness J:278765
preweaning lethality, complete penetrance J:278765
Tuba1aJna/Tuba1a+
involves: BALB/cAnN * C3H/HeH 		abnormal Ammon gyrus morphology J:117881
abnormal auditory cortex morphology J:117881
abnormal cerebral cortex morphology J:117881
abnormal dentate gyrus morphology J:117881
abnormal hippocampal mossy fiber morphology J:117881
abnormal hippocampus morphology J:117881
abnormal hippocampus pyramidal cell layer J:117881
abnormal nest building behavior J:117881
abnormal neuronal migration J:117881
abnormal somatosensory cortex morphology J:117881
abnormal spatial working memory J:117881
abnormal visual cortex morphology J:117881
decreased anxiety-related response J:117881
decreased body weight J:117881
decreased hippocampus pyramidal cell number J:117881
hyperactivity J:117881
Tuba1aquas/Tuba1aquas
involves: C57BL/6J 		abnormal cerebral cortex morphology J:278765
abnormal neuron physiology J:278765
abnormal neuronal migration J:278765
abnormal neuronal precursor cell number J:278765
abnormal spine curvature J:278765
decreased neuronal precursor proliferation J:278765
enlarged lateral ventricles J:278765
enlarged third ventricle J:278765
increased neuron apoptosis J:278765
increased neuronal precursor proliferation J:278765
Tuba1aRgsc1736/Tuba1a+
C3.B6-Tuba1aRgsc1736 		abnormal cerebral cortex pyramidal cell morphology J:180670
abnormal dendrite morphology J:180670
abnormal neuron morphology J:180670
abnormal response to novel object J:180670
decreased anxiety-related response J:180670
increased locomotor activity J:180670
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory