Twist1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Twist1
twist basic helix-loop-helix transcription factor 1
MGI:98872

50 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(CAG-cat,-Twist1)1Dbsp/0 Tg(Col2a1-cre)1Bhr/0 involves: C57BL/6 * FVB * SJL	abnormal long bone epiphyseal plate morphology	J:178268
	abnormal long bone epiphyseal plate proliferative zone	J:178268
	abnormal ossification involved in bone maturation	J:178268
	decreased body size	J:178268
	decreased body weight	J:178268
	decreased bone trabecula number	J:178268
	decreased trabecular bone thickness	J:178268
	decreased trabecular bone volume	J:178268
	increased width of hypertrophic chondrocyte zone	J:178268
	short limbs	J:178268
Twist1^{em1(IMPC)Rbrc}/Twist1⁺ C57BL/6NJcl-Twist1^{em1(IMPC)Rbrc}/Rbrc	abnormal autopod morphology	J:211773
	abnormal brain morphology	J:211773
	abnormal cranium morphology	J:211773
	abnormal digit morphology	J:211773
	abnormal nail morphology	J:211773
	abnormal pelvic girdle bone morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal vertebrae morphology	J:211773
	abnormal vertebral arch morphology	J:211773
	abnormal zygomatic bone morphology	J:211773
	decreased prepulse inhibition	J:211773
	decreased total body fat amount	J:211773
	increased lean body mass	J:211773
Twist1^Pas/Twist1⁺ involves: C57BL/6 * PDT/Pas	cleft palate	J:86815
Twist1^Pas/Twist1⁺ involves: C57BL/6 * PDT/Pas	polydactyly	J:86815
Twist1^Pas/Twist1^Pas involves: C57BL/6 * PDT/Pas	exencephaly	J:86815
Twist1^Pas/Twist1^Pas involves: C57BL/6 * PDT/Pas	prenatal lethality, incomplete penetrance	J:86815
Twist1^Pde/Twist1⁺ involves: 129S1/Sv * C57BL/6J	polydactyly	J:69450
Twist1^Pde/Twist1^Pde involves: 129S1/Sv * C57BL/6J	embryonic lethality, complete penetrance	J:69450
	exencephaly	J:69450
	open neural tube	J:69450
Twist1^Ska10/Twist1⁺ C57BL/6J-Twist1^Ska10	polydactyly	J:90056
	premature coronal suture closure	J:90056
	premature cranial suture closure	J:90056
	premature lambdoid suture closure	J:90056
Twist1^Ska10/Twist1⁺ involves: C57BL/6J	abnormal gait	J:89098
	abnormal limb bone morphology	J:89098
	decreased body size	J:89098
	polydactyly	J:89098
Twist1^Ska10/Twist1^Ska10 C57BL/6J-Twist1^Ska10	abnormal bone ossification	J:90056
	abnormal clavicle morphology	J:90056
	abnormal osteoblast differentiation	J:90056
	abnormal rib morphology	J:90056
	neonatal lethality, complete penetrance	J:90056
	normal nervous system phenotype	J:90056
	polydactyly	J:90056
	premature endochondral bone ossification	J:90056
	short limbs	J:90056
Twist1^tm1Bhr/Twist1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal limb morphology	J:79294
	normal craniofacial phenotype	J:79294
	premature coronal suture closure	J:79294
	premature cranial suture closure	J:79294
	temporal bone hypoplasia	J:79294
Twist1^tm1Bhr/Twist1⁺ involves: 129S7/SvEvBrd	premature cranial suture closure	J:108218
Twist1^tm1Bhr/Twist1⁺ involves: 129S7/SvEvBrd * C57BL/6	enlarged interparietal bone	J:44379
Twist1^tm1Bhr/Twist1⁺ involves: 129S7/SvEvBrd * C57BL/6	polydactyly	J:44379
Twist1^tm1Bhr/Twist1⁺ involves: 129S7/SvEvBrd * C57BL/6J	polydactyly	J:128714
Twist1^tm1Bhr/Twist1⁺ involves: 129S7/SvEvBrd * C57BL/6J	short temporal bone squamous part	J:128714
Twist1^tm1Bhr/Twist1⁺ involves: 129S/Sv * 129X1/SvJ * C57BL/6	abnormal osteoblast differentiation	J:90056
	premature cranial suture closure	J:90056
Twist1^tm1Bhr/Twist1^tm1Bhr involves: 129S7/SvEvBrd	abnormal muscle development	J:124278
Twist1^tm1Bhr/Twist1^tm1Bhr involves: 129S7/SvEvBrd * C57BL/6	embryonic lethality, complete penetrance	J:24349
	exencephaly	J:24349
	open neural tube	J:24349
Twist1^tm1Bhr/Twist1^tm1Bhr involves: 129S7/SvEvBrd * C57BL/6J	abnormal forelimb morphology	J:128714
	exencephaly	J:128714
	internal hemorrhage	J:128714
Twist1^tm1Bhr/Twist1^tm2.1Bhr involves: 129S7/SvEvBrd * C57BL/6J	abnormal forelimb morphology	J:128714
	exencephaly	J:128714
	internal hemorrhage	J:128714
Twist1^tm1Bhr/Twist1^tm2Bhr involves: 129S7/SvEvBrd * C57BL/6J	polydactyly	J:128714
	short temporal bone squamous part	J:128714
Twist1^tm2Bhr/Twist1^tm2Bhr involves: 129S7/SvEvBrd * C57BL/6J	normal skeleton phenotype	J:128714

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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