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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tyr
tyrosinase
MGI:98880
119 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
a/a
Lystbg/Lystbg
Tyrc/Tyrc
involves: C3H/Rl * C57BL/6J 		abnormal choroid melanin granule morphology J:5346
abnormal melanogenesis J:5346
abnormal melanosome morphology J:5346
abnormal retina melanin granule morphology J:5346
A/A
Tyrc-ch/Tyrc-ch
Not Specified 		abnormal coat appearance J:36414
abnormal coat/hair pigmentation J:36414
abnormal hair follicle pheomelanosome pheomelanin content J:36414
a/a
Tyrc-i/Tyrc-i
involves: STOCK Tyrc-r 		abnormal coat/hair pigmentation J:83666
diluted coat color J:83666
a/a
Tyrc/Tyrc
involves: C57BL/6J 		abnormal melanogenesis J:5346
a/a
Tyrc/Tyrem2Ove
involves: C57BL/6 * FVB 		decreased eye pigmentation J:94077
diluted coat color J:94077
a/a
Tyrc/Tyrem4Ove
involves: C57BL/6 * FVB 		abnormal eye pigmentation J:94077
diluted coat color J:94077
a/a
Tyrc/Tyrem9Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
a/a
Tyrc/Tyrem14Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
a/a
Tyrem2Ove/Tyrem2Ove
involves: C57BL/6 * FVB 		abnormal eye pigmentation J:94077
abnormal tail pigmentation J:94077
diluted coat color J:94077
a/a
Tyrem4Ove/Tyrem4Ove
involves: C57BL/6 * FVB 		abnormal eye pigmentation J:94077
decreased tail pigmentation J:94077
diluted coat color J:94077
a/a
Tyrem14Ove/Tyrem14Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
A/a
Tyrem15Ove/Tyrem15Ove
involves: C57BL/6 * FVB 		decreased tail pigmentation J:94077
diluted coat color J:94077
A/?
Tyrc/Tyrem1Ove
involves: C57BL/6 * FVB 		decreased eye pigmentation J:94077
diluted coat color J:94077
A/?
Tyrc/Tyrem6Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
variegated eye pigmentation pattern J:94077
A/?
Tyrc/Tyrem7Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
A/?
Tyrc/Tyrem12Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
A/?
Tyrc/Tyrem13Ove
involves: C57BL/6 * FVB 		normal pigmentation phenotype J:94077
A/?
Tyrem1Ove/Tyrem1Ove
involves: C57BL/6 * FVB 		diluted coat color J:94077
A/?
Tyrem7Ove/Tyrem7Ove
involves: C57BL/6 * FVB 		abnormal eye pigmentation J:94077
diluted coat color J:94077
A/?
Tyrem8Ove/Tyrem8Ove
involves: C57BL/6 * FVB 		decreased ear pigmentation J:94077
decreased tail pigmentation J:94077
diluted coat color J:94077
variegated eye pigmentation pattern J:94077
A/?
Tyrem9Ove/Tyrem9Ove
involves: C57BL/6 * FVB 		decreased eye pigmentation J:94077
diluted coat color J:94077
A/?
Tyrem12Ove/Tyrem12Ove
involves: C57BL/6 * FVB 		decreased eye pigmentation J:94077
diluted coat color J:94077
A/?
Tyrem13Ove/Tyrem13Ove
involves: C57BL/6 * FVB 		normal pigmentation phenotype J:94077
Atm1.1Arte/Atm1.1Arte
Tyrtm1Arte/Tyrtm1Arte
C57BL/6NTac-Atm1.1Arte Tyrtm1Arte 		absent coat pigmentation J:213411
absent eye pigmentation J:213411
Arb2aTg(Tyr)TpNpin/Arb2a+
involves: FVB/N 		head spot J:260599
Arb2aTg(Tyr)TpNpin/Arb2aTg(Tyr)TpNpin
involves: FVB/N 		abnormal cranial nerve morphology J:260599
abnormal craniofacial morphology J:260599
abnormal facial nerve morphology J:260599
abnormal heart morphology J:260599
abnormal neural crest cell migration J:260599
abnormal oropharynx morphology J:260599
abnormal outer ear morphology J:260599
abnormal semicircular canal morphology J:260599
abnormal seminiferous tubule morphology J:329885
abnormal uterine horn morphology J:260599
absent coat pigmentation J:260599
blepharoptosis J:260599
circling J:260599
cleft palate J:260599
cryptorchism J:260599
decreased cell proliferation J:260599
decreased neural crest cell proliferation J:260599
delayed fontanelle closure J:260599
delayed vaginal opening J:260599
normal digestive/alimentary phenotype J:260599
exencephaly J:260599
facial asymmetry J:260599
heart left ventricle hypertrophy J:260599
hydrocephaly J:260599
impaired olfaction J:260599
increased heart weight J:260599
increased neural crest cell apoptosis J:260599
olfactory bulb hypoplasia J:260599
postnatal growth retardation J:260599
postnatal lethality, incomplete penetrance J:260599
reduced fertility J:260599
renal hypoplasia J:260599
retina coloboma J:260599
sex reversal J:260599
small penis J:260599
small seminal vesicle J:260599
thymus hypoplasia J:260599
Arb2aTg(Tyr)TpNpin/Arb2aTg(Tyr)TpNpin
Gata4tm1(cre)Svs/Gata4+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal neural crest cell migration J:260599
Chd7Gt(S20-7E1)Sor/Chd7+
Arb2aTg(Tyr)TpNpin/Arb2a+
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal optic fissure closure J:260599
circling J:260599
decreased body size J:260599
postnatal lethality, incomplete penetrance J:260599
prenatal lethality, incomplete penetrance J:260599
retina coloboma J:260599
sex reversal J:260599
Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Tyrc-2J/Tyrc-2J
B6.Cg-Tyrc-2J Cyp1b1tm1Gonz 		abnormal iridocorneal angle J:82280
abnormal trabecular meshwork morphology J:82280
absent Schlemm's canal J:82280
anterior iris synechia J:82280
Dp(11Cops3-Rnf112)1Jrl/0
Tyrc-Brd/Tyrc-Brd
B6Brd.Cg-Tyrc-Brd Dp(11Cops3-Rnf112)1Jrl 		abnormal contextual conditioning behavior J:114996
abnormal nest building behavior J:138598
abnormal social investigation J:138598
abnormal social/conspecific interaction behavior J:138598
decreased abdominal fat pad weight J:138598
decreased body weight J:138598
decreased brain weight J:138598
decreased exploration in new environment J:114996
decreased vertical activity J:114996
decreased vocalization J:138598
hyperactivity J:114996
increased anxiety-related response J:138598
Foxc1tm1Blh/Foxc1+
Tyrc-2J/Tyrc-2J
B6.Cg-Tyrc-2J Foxc1tm1Blh 		abnormal aqueous drainage system morphology J:82280
abnormal trabecular meshwork morphology J:82280
absent Schlemm's canal J:82280
iris synechia J:82280
GpnmbR150X/GpnmbR150X
Tyrc-2J/Tyrc-2J
Tyrp1b/Tyrp1b
B6.Cg-Tyrp1b GpnmbR150X Tyrc-2J 		normal vision/eye phenotype J:128215
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 		increased glioblastoma incidence J:172585
increased tumor growth/size J:172585
premature death J:172585
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 		increased glioblastoma incidence J:172585
premature death J:172585
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * C57BL/6 		normal mortality/aging J:172585
normal neoplasm J:172585
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J
involves: C57BL/6 * CBA 		normal immune system phenotype J:172226
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
involves: C57BL/6 		normal immune system phenotype J:172226
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		decreased circulating interferon-alpha level J:172226
decreased circulating interferon-beta level J:172226
decreased susceptibility to bacterial infection J:172226
In(11Trp53;11Wnt3)8Brd/+
Tyrc-Brd/Tyrc-Brd
involves: 129S7/SvEvBrd * C57BL/6Brd 		normal pigmentation phenotype J:56548
Lgi1tm1.1Jkc/Lgi1+
Tyrc-Brd/Tyrc-Brd
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc 		abnormal eye pigmentation J:158715
absent coat pigmentation J:158715
Lgi1tm1.1Jkc/Lgi1tm1.1Jkc
Tyrc-Brd/Tyrc-Brd
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc 		abnormal coat/hair pigmentation J:158715
abnormal eye pigmentation J:158715
clonic seizures J:158715
decreased body size J:158715
enhanced AMPA-mediated synaptic currents J:158715
enhanced NMDA-mediated synaptic currents J:158715
increased miniature excitatory postsynaptic current frequency J:158715
normal nervous system phenotype J:158715
postnatal lethality, complete penetrance J:158715
seizures J:158715
Ltftm1(icre)Tdku/Ltftm1(icre)Tdku
Tyrc-2J/Tyrc-2J
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:211105
Mecp2em1Dkatz/Mecp2+
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		abnormal locomotor behavior J:101977
normal reproductive system phenotype J:101977
Mecp2em1Dkatz/Mecp2em1Dkatz
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		female infertility J:101977
Mecp2em1Dkatz/Y
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		premature death J:101977
Mesdtm2.1Bch/Tyrc-3YPSd
involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J 		absent mesoderm J:209024
failure to gastrulate J:209024
small embryonic epiblast J:209024
Mlanatm1.2Bee/Mlanatm1.2Bee
Tyrc/Tyrc
involves: 129S/SvEv * C57BL/6 * FVB/N * SJL 		abnormal hair follicle melanocyte morphology J:194886
absent skin pigmentation J:194886
Oca2p/Oca2p
Tyrc-i/Tyrc-i
involves: STOCK Tyrc-r 		abnormal coat/hair pigmentation J:83666
Plin2tm1Itl/Plin2tm1Itl
Rpe65tm1Tmr/Rpe65tm1Tmr
Tyrc-2J/Tyrc-2J
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6 		abnormal vitamin A metabolism J:142021
Tdo2chky/Tdo2chky
Tyrc/Tyrc
STOCK Tdo2chky/J 		abnormal lens morphology J:149273
cataract J:149273
yellow coat color J:149273
Tenm4l7Rn3-4R/Tyrc-26DVT
involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock 		abnormal cervical axis morphology J:96673
abnormal limb bud morphology J:96673
abnormal vasculogenesis J:96673
decreased body size J:96673
embryonic growth retardation J:96673
kinked neural tube J:96673
lumbar vertebral fusion J:96673
normal mortality/aging J:96673
prenatal lethality, complete penetrance J:96673
thoracic vertebral fusion J:96673
Thtm1Srt/Thtm1Srt
Tyrc/Tyrc
involves: 129S2/SvPas * C57BL/6J * ICR 		abnormal adrenaline level J:54692
abnormal noradrenaline level J:54692
decreased dopamine level J:54692
prenatal lethality, complete penetrance J:54692
Tyrc-2CHLb/Tyrc-2CHLb
involves: 101/Rl * C3H/Rl 		prenatal lethality, complete penetrance J:10322, J:100221
Tyrc-2CHLb/Tyrc-202G
involves: 101/Rl * C3H/Rl 		prenatal lethality, complete penetrance J:100221
Tyrc-2CHLb/Tyrc
involves: 101/Rl * C3H/Rl 		absent coat pigmentation J:100221
Tyrc-26DVT/Tyr+
involves: 101/Rl * C3H/Rl * T-stock 		no abnormal phenotype detected J:100221
Tyrc-26DVT/Tyrc-26DVT
involves: 101/Rl * C3H/Rl * T-stock 		embryonic lethality before implantation, complete penetrance J:23420, J:100221, J:141526
Tyrc-ch/Del(7)Tyrc-3H
involves: 101/H * C3H/HeH 		abnormal coat/hair pigmentation J:5063
diluted coat color J:5063
Tyrc-ch/Del(7)Tyrc-6H
involves: 101/H * C3H/HeH 		abnormal coat/hair pigmentation J:5741
diluted coat color J:5741
Tyrc/Del(7)Tyrc-3H
involves: 101/H * C3H/HeH 		absent coat pigmentation J:5063
Tyrc/Tyrc-26DVT
involves: 101/Rl * C3H/Rl * T-stock 		absent coat pigmentation J:100221
War/War
Tyrc-e/Tyrc-e
PBI 		abnormal physiological response to xenobiotic J:5635
decreased physiological sensitivity to xenobiotic J:5635
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory