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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tyrp1
tyrosinase-related protein 1
MGI:98881
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
a/a
Lystbg/Lystbg
Tyrp1b/Tyrp1b
involves: C3H/Rl * C57BL/6J 		abnormal choroid melanin granule morphology J:5346
abnormal retina melanin granule morphology J:5346
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
C57L/J 		abnormal coat/hair pigmentation J:5095
abnormal melanocyte morphology J:5095
diluted coat color J:5095
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
involves: C58 * CT/Ch 		diluted coat color J:13094
a/a
Tyrp1B-lt/Tyrp1+
Not Specified 		abnormal dorsoventral coat patterning J:13094
abnormal hair shaft melanin granule distribution J:13094
abnormal hair shaft melanin granule morphology J:13094
reduced hair shaft melanin granule number J:13094
a/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified 		abnormal dorsoventral coat patterning J:13094
abnormal hair follicle melanin granule morphology J:13094
abnormal hair shaft melanin granule distribution J:13094
abnormal hair shaft melanin granule morphology J:13094
enlarged hair follicle melanin granules J:13094
reduced hair shaft melanin granule number J:13094
A/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified 		diluted coat color J:13094
a/a
Tyrp1b/Tyrp1b
involves: C57BL/6J 		abnormal melanosome morphology J:5346
a/a
Tyrp1b/Tyrp1b
Not Specified 		abnormal coat/hair pigmentation J:12970
abnormal eye pigmentation J:12970
abnormal melanocyte morphology J:12970
a/a
Tyrp1b/Tyrp1b
wad/wad+
Not Specified 		diluted coat color J:162146
a/a
Tyrp1b/Tyrp1b
wad/wad
Not Specified 		diluted coat color J:162146
A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Not Specified 		decreased eye pigmentation J:29744
diluted coat color J:29744
Ay/a
Tyrp1B-lt/?
Not Specified 		yellow coat color J:13094
Cdk5rap2an/Cdk5rap2an
Tyrp1B-lt/Tyrp1B-lt
WBB6F1 		abnormal mitosis J:7537
aneuploidy J:7537
forebrain hypoplasia J:160533
impaired hematopoiesis J:7003
increased histiocytic sarcoma incidence J:102334
microcephaly J:160533
parturition failure J:753
GpnmbR150X/GpnmbR150X
Tyrc-2J/Tyrc-2J
Tyrp1b/Tyrp1b
B6.Cg-Tyrp1b GpnmbR150X Tyrc-2J 		normal vision/eye phenotype J:128215
GpnmbR150X/GpnmbR150X
Tyrp1b/Tyrp1b
B6.D2-Tyrp1b GpnmbR150X 		abnormal intraocular pressure J:128215
abnormal iris morphology J:128215
abnormal iris pigmentation J:128215
iris atrophy J:128215
GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
DBA/2J 		abnormal iris pigment epithelium J:54013
abnormal iris stroma morphology J:54013
optic nerve atrophy J:54013
retina ganglion cell degeneration J:54013
GpnmbR150X/GpnmbR150X
Tyrp1isa/Tyrp1isa
involves: C57BL/6J * DBA/2J 		abnormal iris pigment epithelium J:54013
abnormal iris stroma morphology J:54013
optic nerve atrophy J:54013
retina ganglion cell degeneration J:54013
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
Oca2p/Oca2p
Tyrp1b/Tyrp1b
involves: CT/Ch * YZ57/Ch 		abnormal hair cycle J:83269
delayed hair regrowth J:83269
diluted coat color J:83269
premature hair loss J:83269
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6 		abnormal tumor susceptibility J:138466
Rgsc58/Rgsc58+
Tyrp1b/Tyrp1b
involves: C57BL/6JJcl * DBA/2JJcl 		white spotting J:133634
Tyrp1B-w/Tyrp1+
involves: 101/Rl * C3H/Rl 		diluted coat color J:13492, J:18590
Tyrp1B-w/Tyrp1B-w
involves: 101/Rl * C3H/Rl 		decreased eye pigmentation J:13492
diluted coat color J:13492, J:18590
Tyrp1B-w/Tyrp1b
involves: 101/Rl * C3H/Rl 		decreased eye pigmentation J:13492
diluted coat color J:13492, J:18590
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory