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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		U2af1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
MGI:98884
29 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Mx1-cre)1Cgn/0
U2af1tm1.1Hev/U2af1+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 * C57BL/6J * CBA/J 		abnormal bone marrow cell morphology/development J:267082
decreased erythrocyte cell number J:267082
decreased hematocrit J:267082
decreased hematopoietic stem cell number J:267082
decreased hemoglobin content J:267082
decreased leukocyte cell number J:267082
increased mean corpuscular volume J:267082
macrocytic anemia J:267082
normal mortality/aging J:267082
normal neoplasm J:267082
Tg(Mx1-cre)1Cgn/0
U2af1tm1Mohi/U2af1tm1Mohi
involves: C57BL/6J * CBA/J 		abnormal bone marrow cell morphology/development J:308564
abnormal hematopoietic stem cell physiology J:308564
anemia J:308564
bone marrow failure J:308564
decreased bone marrow cell number J:308564
decreased common myeloid progenitor cell number J:308564
decreased erythrocyte cell number J:308564
decreased erythroid progenitor cell number J:308564
decreased hematopoietic stem cell number J:308564
decreased hemoglobin content J:308564
decreased leukocyte cell number J:308564
decreased megakaryocyte progenitor cell number J:308564
decreased neutrophil cell number J:308564
pancytopenia J:308564
premature death J:308564
thrombocytopenia J:308564
U2af1em1(IMPC)J/U2af1+
C57BL/6NJ-U2af1em1(IMPC)J/Mmjax 		abnormal auditory brainstem response J:211773
abnormal coat/hair pigmentation J:211773
cornea opacity J:211773
increased grip strength J:211773
irregularly shaped pupil J:211773
persistence of hyaloid vascular system J:211773
U2af1em1(IMPC)J/U2af1em1(IMPC)J
C57BL/6NJ-U2af1em1(IMPC)J/Mmjax 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory