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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Uox
urate oxidase
MGI:98907
53 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Uoxem1(IMPC)Ccpcz/Uox+
C57BL/6NCrl-Uoxem1(IMPC)Ccpcz/Ccpcz 		abnormal pancreas morphology J:211773
decreased mean corpuscular hemoglobin J:211773
enlarged pancreas J:211773
small pancreas J:211773
Uoxem1(IMPC)Ccpcz/Uoxem1(IMPC)Ccpcz
C57BL/6NCrl-Uoxem1(IMPC)Ccpcz/Ccpcz 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Uoxem1Cli/Uoxem1Cli
C57BL/6J-Uoxem1Cli 		abnormal cytokine level J:271949
abnormal kidney interstitium morphology J:271949
abnormal kidney morphology J:271949
abnormal nephron morphology J:271949
decreased circulating triglyceride level J:271949
decreased insulin secretion J:271949
decreased pancreatic beta cell mass J:271949
decreased survivor rate J:271949
dilated renal tubule J:271949
impaired glucose tolerance J:271949
increased blood urea nitrogen level J:271949
increased blood uric acid level J:271949
increased circulating cholesterol level J:271949
increased circulating creatinine level J:271949
increased circulating LDL cholesterol level J:271949
increased circulating triglyceride level J:271949
increased glomerular capsule space J:271949
increased pancreatic beta cell apoptosis J:271949
increased susceptibility to non-insulin-dependent diabetes J:271949
increased systemic arterial blood pressure J:271949
kidney inflammation J:271949
nephron necrosis J:271949
premature death J:271949
renal interstitial fibrosis J:271949
Uoxtm1Bay/Uoxtm1Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal kidney morphology J:16490, J:103187
abnormal nephron morphology J:16490
abnormal renal glomerulus morphology J:103187
abnormal renal tubule morphology J:16490
abnormal urine color J:103187
crystalluria J:103187
cystolithiasis J:103187
decreased urine osmolality J:103187
dilated kidney collecting duct J:103187
dilated renal tubule J:16490
distended urinary bladder J:103187
hydronephrosis J:16490, J:103187
increased blood urea nitrogen level J:103187
increased blood uric acid level J:16490
increased glomerular capsule space J:16490
increased urine uric acid level J:16490, J:103187
kidney cortex cyst J:16490
kidney cyst J:16490
pale kidney J:16490
polydipsia J:103187
polyuria J:103187
premature death J:16490
renal cast J:16490
renal fibrosis J:103187
renal glomerulus atrophy J:16490
renal tubule atrophy J:103187
small kidney J:16490
tubulointerstitial nephritis J:16490
uremia J:103187
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory