Uros Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Uros
uroporphyrinogen III synthase
MGI:98917

35 phenotypes from 6 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Uros^tm1Cged/Uros^tm1Cged involves: 129S2/SvPas	abnormal proximal convoluted tubule morphology	J:105776
	abnormal renal glomerulus morphology	J:105776
	abnormal renal tubule morphology	J:105776
	abnormal skeleton morphology	J:105776
	anisocytosis	J:105776
	decreased birth body size	J:105776
	enlarged liver	J:105776
	enlarged spleen	J:105776
	erythrodontia	J:105776
	erythruria	J:105776
	fragile skeleton	J:105776
	hemolytic anemia	J:105776
	hepatic steatosis	J:105776
	hypochromic microcytic anemia	J:105776
	increased bone marrow cell number	J:105776
	increased spleen red pulp amount	J:105776
	poikilocytosis	J:105776
	porphyria	J:105776
	skin photosensitivity	J:105776
Uros^tm1Rjde/Uros^tm1Rjde involves: 129S6/SvEvTac * C57BL/6	preweaning lethality, complete penetrance	J:132542
Uros^tm1Rjde/Uros^tm3Rjde involves: 129S6/SvEvTac * C57BL/6	increased porphyrin level	J:132542
Uros^tm2Cged/Uros^tm2Cged involves: 129S2/SvPas	embryonic lethality before implantation, complete penetrance	J:107043
Uros^tm2Rjde/Uros^tm2Rjde involves: 129S6/SvEvTac * C57BL/6	preweaning lethality, complete penetrance	J:132542
Uros^tm2Rjde/Uros^tm3Rjde involves: 129S6/SvEvTac * C57BL/6	abnormal enzyme/coenzyme activity	J:132542
	abnormal erythropoiesis	J:132542
	decreased circulating haptoglobin level	J:132542
	enlarged spleen	J:132542
	normal hematopoietic system phenotype	J:132542
	hemolysis	J:132542
	hemolytic anemia	J:132542
	increased porphyrin level	J:132542
	increased spleen iron level	J:132542
	reticulocytosis	J:132542
Uros^tm2Rjde/Uros^tm3Rjde involves: 129S6/SvEvTac * C57BL/6 * SKH1	abnormal dermal layer morphology	J:132542
	abnormal dermis papillary layer morphology	J:132542
	acanthosis	J:132542
	increased porphyrin level	J:132542
	mixed cellular infiltration to dermis	J:132542
	skin photosensitivity	J:132542
	thick skin	J:132542
Uros^tm3Rjde/Uros^tm3Rjde involves: 129S6/SvEvTac * C57BL/6	abnormal enzyme/coenzyme activity	J:132542
	normal hematopoietic system phenotype	J:132542
	increased porphyrin level	J:132542
Uros^tm3Rjde/Uros^tm3Rjde involves: 129S6/SvEvTac * C57BL/6 * SKH1	increased porphyrin level	J:132542
	skin photosensitivity	J:132542
	thick epidermis	J:132542
Uros^tm3Rjde/Uros^tm4Rjde involves: 129S6/SvEvTac * C57BL/6	increased porphyrin level	J:132542
Uros^tm4Rjde/Uros^tm4Rjde involves: 129S6/SvEvTac * C57BL/6	preweaning lethality, complete penetrance	J:132542

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24