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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vav1
vav 1 oncogene
MGI:98923
62 phenotypes from 12 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Vav1m1Anu/Vav1m1Anu
C57BL/6JAnu-Vav1m1Anu 		increased T cell number J:104190
Vav1m1Btlr/Vav1m1Btlr
C57BL/6J-Vav1m1Btlr 		abnormal humoral immune response J:265128
decreased B-1 B cell number J:265128
decreased CD4-positive, alpha-beta T cell number J:265128
decreased CD8-positive, alpha-beta T cell number J:265128
decreased CD8-positive, naive alpha-beta T cell number J:265128
decreased IgD level J:265128
decreased IgG level J:265128
decreased single-positive T cell number J:265128
decreased T cell number J:265128
increased central memory CD4-positive, alpha-beta T cell number J:265128
increased central memory CD8 positive, alpha-beta T cell number J:265128
increased effector memory CD4-positive, alpha-beta T cell number J:265128
increased IgM level J:265128
Vav1m2Btlr/Vav1m2Btlr
C57BL/6J-Vav1m2Btlr 		decreased B-1 B cell number J:265130
Vav1M3Btlr/Vav1M3Btlr
C57BL/6J-Vav1M3Btlr 		decreased IgG level J:272527
impaired humoral immune response J:272527
Vav1M4Btlr/Vav1M4Btlr
C57BL/6J-Vav1M4Btlr 		abnormal CD4-positive T cell differentiation J:272528
abnormal CD8-positive, alpha-beta T cell differentiation J:272528
abnormal T cell differentiation J:272528
decreased B-1 B cell number J:272528
decreased CD4-positive, alpha-beta T cell number J:272528
decreased CD8-positive, naive alpha-beta T cell number J:272528
increased central memory CD4-positive, alpha-beta T cell number J:272528
increased central memory CD8 positive, alpha-beta T cell number J:272528
increased effector memory CD4-positive, alpha-beta T cell number J:272528
increased effector memory CD8-positive, alpha-beta T cell number J:272528
Vav1M5Btlr/Vav1M5Btlr
C57BL/6J-Vav1M5Btlr 		decreased CD8-positive, alpha-beta T cell number J:272529
Vav1tm1Bbd/Vav1+
involves: 129S2/SvPas * C57BL/6J 		transmission ratio distortion J:22517
Vav1tm1Bbd/Vav1tm1Bbd
involves: 129S2/SvPas * C57BL/6J 		embryonic lethality between implantation and somite formation, complete penetrance J:22517
failure of blastocyst to hatch from the zona pellucida J:22517
Vav1tm1Tyb/Vav1tm1Tyb
C.129S2-Vav1tm1Tyb 		abnormal negative T cell selection J:79323
Vav1tm1Tyb/Vav1tm1Tyb
either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd) 		abnormal CD8-positive, alpha-beta T cell physiology J:190087
abnormal immune system physiology J:190087
abnormal interleukin-2 secretion J:190087
abnormal lymphocyte cell number J:190087
abnormal T cell number J:190087
decreased double-positive T cell number J:190087
increased DN2 thymocyte number J:190087
increased DN3 thymocyte number J:190087
increased double-negative T cell number J:190087
Vav1tm1Tyb/Vav1tm1Tyb
involves: 129S2/SvPas 		abnormal double-negative T cell morphology J:79323
abnormal T cell physiology J:79323, J:86654
decreased double-positive T cell number J:79323
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:79323
decreased T cell proliferation J:86654
decreased thymocyte number J:86654
thymus hypoplasia J:79323
Vav1tm1Tyb/Vav1tm1Tyb
involves: 129S2/SvPas * 129S8/SvEv 		abnormal T cell physiology J:113270
decreased CD4-positive, alpha-beta T cell number J:113270
decreased double-negative T cell number J:113270
decreased T cell proliferation J:113270
Vav1tm1Tyb/Vav1tm1Tyb
involves: 129S2/SvPas * C57BL/10 * C57BR/cd 		abnormal CD4-positive, alpha beta T cell morphology J:79323
abnormal T cell physiology J:128985
decreased interleukin-2 secretion J:128985
decreased T cell proliferation J:128985
decreased tumor necrosis factor secretion J:128985
Vav1tm1Tyb/Vav1tm1Tyb
involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd 		abnormal CD4-positive, alpha beta T cell morphology J:113270
abnormal negative T cell selection J:113270
Vav1tm2Bbd/Vav1tm2Bbd
B6.129-Vav1tm2Bbd 		abnormal CD4-positive T cell differentiation J:141390
abnormal positive T cell selection J:141390
abnormal T cell physiology J:141390
decreased double-positive T cell number J:141390
decreased interleukin-4 secretion J:71161
decreased NK T cell number J:71161
decreased T cell number J:141390
normal immune system phenotype J:71161
impaired natural killer cell mediated cytotoxicity J:71161
Vav1tm2Bbd/Vav1tm2Bbd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell number J:55647
abnormal lymph node cell ratio J:69806
abnormal response to infection J:55647
abnormal splenic cell ratio J:69806
abnormal T cell differentiation J:47596
abnormal T cell number J:47596
decreased B cell proliferation J:55647, J:69806
decreased B-1 B cell number J:55647
decreased CD4-positive, alpha-beta T cell number J:47596
decreased CD8-positive, alpha-beta T cell number J:47596
decreased IgG1 level J:55647
decreased IgG2a level J:55647
decreased IgG3 level J:69806
decreased IgG level J:55647
increased double-negative T cell number J:47596
increased transitional stage B cell number J:69806
Vav1tm2Bbd/Vav1tm2Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal T cell activation J:47596
abnormal T cell differentiation J:47596
decreased B-1 B cell number J:47596
decreased CD4-positive, alpha-beta T cell number J:47596
decreased CD8-positive, alpha-beta T cell number J:47596
decreased interleukin-2 secretion J:47596
decreased T cell proliferation J:47596
normal immune system phenotype J:47596
thymus hypoplasia J:47596
Vav1tm2Tyb/Vav1tm2Tyb
involves: 129S4/SvJae * 129S8/SvEv 		abnormal T cell physiology J:113270
decreased CD4-positive, alpha-beta T cell number J:113270
decreased double-negative T cell number J:113270
decreased T cell proliferation J:113270
Vav1tm2Tyb/Vav1tm2Tyb
involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd 		abnormal CD4-positive, alpha beta T cell morphology J:113270
abnormal negative T cell selection J:113270
Vav1tm3Tyb/Vav1tm3Tyb
involves: 129S4/SvJae * 129S8/SvEv 		no abnormal phenotype detected J:113270
Vav1tm4Tyb/Vav1tm4Tyb
either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd) 		abnormal CD4-positive, alpha-beta T cell physiology J:190087
abnormal CD8-positive, alpha-beta T cell physiology J:190087
abnormal immune serum protein physiology J:190087
abnormal immune system physiology J:190087
abnormal interleukin-2 secretion J:190087
abnormal lymphocyte cell number J:190087
abnormal T cell number J:190087
abnormal T cell physiology J:190087
increased circulating interferon-gamma level J:190087
increased DN2 thymocyte number J:190087
increased DN3 thymocyte number J:190087
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory