Vav1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vav1
vav 1 oncogene
MGI:98923

50 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cblb^tm1Pngr/Cblb^tm1Pngr Vav1^tm1Tyb/Vav1^tm1Tyb Was^tm1Sbs/Was^tm1Sbs involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac	abnormal T cell physiology	J:79550
Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd B6.129-Itk^tm1Litt Vav1^tm2Bbd	abnormal CD4-positive T cell differentiation	J:141390
	abnormal CD8-positive, alpha-beta T cell differentiation	J:141390
	abnormal positive T cell selection	J:141390
	abnormal T cell morphology	J:141390
	abnormal T cell physiology	J:141390
	decreased CD4-positive, alpha-beta T cell number	J:141390
	decreased CD8-positive, alpha-beta T cell number	J:141390
	decreased double-positive T cell number	J:141390
	decreased T cell number	J:141390
	decreased thymocyte number	J:141390
	increased B cell number	J:141390
	increased T cell apoptosis	J:141390
Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb involves: 129S4/SvJae * 129S8/SvEv	arrested T cell differentiation	J:113270
Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0 involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL	decreased CD4-positive, alpha-beta T cell number	J:113270
Rasgrf2^tm1Esn/Rasgrf2^tm1Esn Vav1^tm1Tyb/Vav1^tm1Tyb involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd	abnormal T cell physiology	J:128985
	decreased interleukin-2 secretion	J:128985
	decreased T cell proliferation	J:128985
	decreased tumor necrosis factor secretion	J:128985
Vav1^tm1Tyb/Vav1^tm1Tyb Vav2^tm1Kdf/Vav2^tm1Kdf involves: 129S1/Sv * 129S2/SvPas	decreased B cell proliferation	J:86654
	decreased double-negative T cell number	J:86654
	decreased double-positive T cell number	J:86654
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:86654
	decreased T cell number	J:86654
	decreased T cell proliferation	J:86654
	decreased thymocyte number	J:86654
Vav1^tm1Tyb/Vav1^tm1Tyb Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac	abnormal macrophage physiology	J:145345
	abnormal neutrophil physiology	J:145345
	abnormal NK cell physiology	J:187430
	decreased interleukin-10 secretion	J:145345
	decreased tumor necrosis factor secretion	J:145345
Vav1^tm1Tyb/Vav1^tm1Tyb Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6	abnormal B cell calcium ion homeostasis	J:86654
	abnormal enterocyte morphology	J:146174
	abnormal humoral immune response	J:86654
	abnormal T cell physiology	J:86654
	arrested B cell differentiation	J:86654
	arrested T cell differentiation	J:86654
	decreased B cell proliferation	J:86654
	decreased double-positive T cell number	J:86654
	decreased follicular B cell number	J:86654
	decreased IgG1 level	J:86654
	decreased IgG2b level	J:86654
	decreased IgG3 level	J:86654
	decreased IgM level	J:86654
	decreased immunoglobulin level	J:86654
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased marginal zone B cell number	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:86654
	decreased T cell number	J:86654
	decreased T cell proliferation	J:86654
	decreased thymocyte number	J:86654
	decreased transitional stage T2 B cell number	J:86654
	impaired wound healing	J:146174
	increased immature B cell number	J:86654
	increased transitional stage T1 B cell number	J:86654
	intestinal ulcer	J:146174
Vav1^tm1Tyb/Vav1^tm1Tyb Vav2^tm1Tnr/Vav2^tm1Tnr involves: 129P2/OlaHsd * 129S2/SvPas	abnormal B cell calcium ion homeostasis	J:69807
	decreased B cell number	J:69807
	decreased B cell proliferation	J:69807
	decreased CD4-positive, alpha-beta T cell number	J:69807
	decreased CD8-positive, alpha-beta T cell number	J:69807
	decreased follicular B cell number	J:69807
	decreased immature B cell number	J:69807
	decreased mature B cell number	J:69807
Vav1^tm1Tyb/Vav1^tm1Tyb Vav3^tm1Swat/Vav3^tm1Swat involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	decreased B cell proliferation	J:86654
	decreased double-negative T cell number	J:86654
	decreased double-positive T cell number	J:86654
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:86654
	decreased T cell number	J:86654
	decreased T cell proliferation	J:86654
Vav1^tm2Bbd/Vav1^tm2Bbd Vav2^tm1Kdf/Vav2^tm1Kdf involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal B cell activation	J:69806
	abnormal B cell differentiation	J:69806
	abnormal lymph node cell ratio	J:69806
	abnormal splenic cell ratio	J:69806
	abnormal T cell differentiation	J:69806
	decreased B cell number	J:69806
	decreased B cell proliferation	J:69806
	decreased B-1 B cell number	J:69806
	decreased CD8-positive, alpha-beta T cell number	J:69806
	decreased IgG1 level	J:69806
	decreased IgG2b level	J:69806
	decreased IgG3 level	J:69806
	decreased IgM level	J:69806
	decreased immunoglobulin level	J:69806
	decreased mature B cell number	J:69806
	decreased T cell number	J:69806
	thymus hypoplasia	J:69806

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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