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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vcam1
vascular cell adhesion molecule 1
MGI:98926
45 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Vcam1tm1Dmil/Vcam1tm1Dmil
C.129S4-Vcam1tm1Dmil 		abnormal chorioallantoic fusion J:69597
decreased cell chemotaxis J:227109
increased B cell number J:69597
increased leukocyte cell number J:69597
increased monocyte cell number J:69597
increased T cell number J:69597
prenatal lethality, incomplete penetrance J:69597
Vcam1tm1Dmil/Vcam1tm1Dmil
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal chorioallantoic fusion J:69597
increased monocyte cell number J:69597
prenatal lethality, incomplete penetrance J:69597
Vcam1tm1Dmil/Vcam1tm1Dmil
either: B6.129S4-Vcam1tm1Dmil or (involves: 129S4/SvJae) 		abnormal chorioallantoic fusion J:69597
prenatal lethality, incomplete penetrance J:69597
Vcam1tm1Dmil/Vcam1tm1Dmil
involves: 129S4/SvJae 		decreased cell chemotaxis J:227109
Vcam1tm1Roml/Vcam1tm1Roml
involves: 129S1/Sv * C57BL/6J 		abnormal allantois morphology J:28110
abnormal cardiovascular system morphology J:23137
abnormal chorioallantoic fusion J:28110
abnormal epicardium morphology J:28110
abnormal extraembryonic tissue morphology J:23137
abnormal interventricular septum morphology J:23137, J:28110
abnormal myocardium layer morphology J:23137
absent epicardium J:23137
decreased embryo size J:23137, J:28110
dilated allantois J:23137
disorganized myocardium J:23137, J:28110
embryonic lethality during organogenesis, complete penetrance J:23137, J:28110
failure of chorioallantoic fusion J:23137
hydropic allantois J:28110
pericardial effusion J:23137, J:28110
thin ventricle myocardium compact layer J:23137, J:28110
Vcam1tm2.1Roml/Vcam1tm2.1Roml
involves: 129S1/Sv * C57BL/6 		preweaning lethality, complete penetrance J:43561
Vcam1tm2Dmil/Vcam1tm2Dmil
B6.129S4-Vcam1tm2Dmil 		decreased cell chemotaxis J:227109
Vcam1tm2Flv/Vcam1tm2Flv
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal blood cell morphology/development J:123142
decreased bone marrow cell number J:123142
Vcam1tm2Flv/Vcam1tm3Flv
Tg(Tek-cre)12Flv/0
involves: 129S1/Sv * C3H * C57BL/6 		abnormal blood cell morphology/development J:107447, J:123142
abnormal bone marrow cell morphology/development J:107447, J:123142
abnormal CD4-positive, alpha-beta T cell physiology J:68147
abnormal CD8-positive, alpha-beta T cell physiology J:68147
abnormal lymphocyte physiology J:68147
abnormal splenic cell ratio J:107447
decreased B cell number J:68147
decreased body weight J:107447
decreased bone marrow cell number J:68147, J:107447
decreased CD4-positive, alpha-beta T cell number J:68147
decreased CD8-positive, alpha-beta T cell number J:68147
decreased immature B cell number J:68147
impaired B cell migration J:68147
increased immature B cell number J:68147
increased leukocyte cell number J:68147, J:107447
spleen hyperplasia J:107447
Vcam1tm2Roml/Vcam1tm2Roml
involves: 129S1/Sv * C57BL/6 		postnatal lethality J:43561
normal reproductive system phenotype J:43561
Vcam1tm2Roml/Vcam1tm2Roml
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal humoral immune response J:68148
decreased B cell number J:68148
decreased mature B cell number J:68148
decreased transitional stage B cell number J:68148
increased B cell number J:68148
increased immature B cell number J:68148
increased mature B cell number J:68148
increased transitional stage B cell number J:68148
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory