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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vcl
vinculin
MGI:98927
64 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Vcltm1Ross/Vcltm1Ross
involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL 		abnormal cardiac muscle relaxation J:129075
abnormal cardiovascular system morphology J:129075
abnormal cardiovascular system physiology J:129075
abnormal impulse conducting system conduction J:129075
abnormal intercalated disk morphology J:129075
abnormal myocardial fiber morphology J:129075
cardiac fibrosis J:129075
cardiac hypertrophy J:129075
congestive heart failure J:129075
decreased cardiac muscle contractility J:129075
dilated cardiomyopathy J:129075
dilated heart left ventricle J:129075
heart block J:129075
increased heart weight J:129075
irregular heartbeat J:129075
premature death J:129075
ventricular tachycardia J:129075
Vcltm1.1Whz/Vcltm1.1Whz
involves: 129/Sv * C57BL/6 * SJL 		abnormal cell adhesion J:163108
abnormal embryonic tissue physiology J:163108
abnormal head development J:163108
abnormal head mesenchyme morphology J:163108
absent brain ventricles J:163108
dilated vasculature J:163108
embryonic lethality during organogenesis, complete penetrance J:163108
exencephaly J:163108
incomplete rostral neuropore closure J:163108
increased apoptosis J:163108
increased embryonic neuroepithelium apoptosis J:163108
Vcltm1Eda/Vcl+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		abnormal heart electrocardiography waveform feature J:92398
abnormal intercalated disk morphology J:92398
abnormal myocardial fiber morphology J:92398
decreased heart left ventricle muscle contractility J:92398
increased susceptibility to induced morbidity/mortality J:92398
prolonged QRS complex duration J:92398
Vcltm1Eda/Vcltm1Eda
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		abnormal cell adhesion J:45781
abnormal cranial nerve morphology J:45781
abnormal ectoderm development J:45781
abnormal embryonic neuroepithelial layer differentiation J:45781
abnormal foregut morphology J:45781
abnormal forelimb bud morphology J:45781
abnormal head shape J:45781
abnormal heart development J:45781
abnormal heart position or orientation J:45781
abnormal mesoderm development J:45781
abnormal neural fold formation J:45781
abnormal neural tube closure J:45781
abnormal pericardial cavity morphology J:45781
abnormal spinal nerve morphology J:45781
absent atrioventricular cushions J:45781
absent brain ventricles J:45781
absent heart valves J:45781
decreased brain size J:45781
decreased cardiac muscle contractility J:45781
decreased embryo size J:45781
decreased embryonic neuroepithelium thickness J:45781
decreased myocardial fiber number J:45781
decreased somite size J:45781
delayed heart development J:45781
embryonic growth arrest J:45781
embryonic growth retardation J:45781
embryonic lethality during organogenesis, complete penetrance J:45781
failure of somite differentiation J:45781
incomplete rostral neuropore closure J:45781
increased fibroblast proliferation J:45781
short rostral-caudal axis J:45781
small brain ventricles J:45781
small dorsal root ganglion J:45781
small forelimb buds J:45781
small heart J:45781
thin myocardium J:45781
wavy neural tube J:45781
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory